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Maximizing wound coverage in full-thickness skin defects: A randomized-controlled trial of autologous skin cell suspension and widely meshed autograft versus standard autografting.
Henry S, Mapula S, Grevious M, Foster KN, Phelan H, Shupp J, Chan R, Harrington D, Mashruwala N, Brown DA, Mir H, Singer G, Cordova A, Rae L, Chin T, Castanon L, Bell D, Hughes W, Molnar JA. Henry S, et al. Among authors: brown da. J Trauma Acute Care Surg. 2024 Jan 1;96(1):85-93. doi: 10.1097/TA.0000000000004120. Epub 2023 Sep 1. J Trauma Acute Care Surg. 2024. PMID: 38098145 Clinical Trial.
Clinical healing (95% reepithelialization) was achieved in 87% and 85% of Control and ASCS+STSG areas, respectively, at 8 weeks. The treatment approaches had similar long-term scarring outcomes and safety profiles, with no unanticipated events and no serious ASCS device-re …
Clinical healing (95% reepithelialization) was achieved in 87% and 85% of Control and ASCS+STSG areas, respectively, at 8 weeks. The treatme …
An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence.
Riviere-Cazaux C, Carlstrom LP, Neth BJ, Olson IE, Rajani K, Rahman M, Ikram S, Mansour MA, Mukherjee B, Warrington AE, Short SC, von Zglinicki T, Brown DA, Burma S, Tchkonia T, Schafer MJ, Baker DJ, Kizilbash SH, Kirkland JL, Burns TC. Riviere-Cazaux C, et al. Among authors: brown da. NPJ Precis Oncol. 2023 Nov 29;7(1):126. doi: 10.1038/s41698-023-00476-8. NPJ Precis Oncol. 2023. PMID: 38030881 Free PMC article. Review.
High-grade gliomas are primary brain tumors that are incredibly refractory long-term to surgery and chemoradiation, with no proven durable salvage therapies for patients that have failed conventional treatments. ...We also discuss how senescent cell clearance can decrease …
High-grade gliomas are primary brain tumors that are incredibly refractory long-term to surgery and chemoradiation, with no proven du …
Efficacy and Safety of Elamipretide in Individuals With Primary Mitochondrial Myopathy: The MMPOWER-3 Randomized Clinical Trial.
Karaa A, Bertini E, Carelli V, Cohen BH, Enns GM, Falk MJ, Goldstein A, Gorman GS, Haas R, Hirano M, Klopstock T, Koenig MK, Kornblum C, Lamperti C, Lehman A, Longo N, Molnar MJ, Parikh S, Phan H, Pitceathly RDS, Saneto R, Scaglia F, Servidei S, Tarnopolsky M, Toscano A, Van Hove JLK, Vissing J, Vockley J, Finman JS, Brown DA, Shiffer JA, Mancuso M; MMPOWER-3 Trial Investigators. Karaa A, et al. Among authors: brown da. Neurology. 2023 Jul 18;101(3):e238-e252. doi: 10.1212/WNL.0000000000207402. Epub 2023 Jun 2. Neurology. 2023. PMID: 37268435 Free PMC article. Clinical Trial.
TRIAL REGISTRATION INFORMATION: Trial registered with clinicaltrials.gov, Clinical Trials Identifier: NCT03323749; submitted on October 12, 2017; first patient enrolled October 9, 2017. CLINICALTRIALS: gov/ct2/show/NCT03323749?term = elamipretide&draw = 2&rank = 9. …
TRIAL REGISTRATION INFORMATION: Trial registered with clinicaltrials.gov, Clinical Trials Identifier: NCT03323749; submitted on October 12, …
Objective assessment of patients with idiopathic normal pressure hydrocephalus following ventriculoperitoneal shunt placement using activity-monitoring data: pilot study.
Jusue-Torres I, Brown DA, Pennington Z, Cogswell PM, Ali F, Graff-Radford N, Jones DT, Cutsforth-Gregory JK, Graff-Radford J, Kaufman KR, Elder BD. Jusue-Torres I, et al. Among authors: brown da. Neurosurg Focus. 2023 Apr;54(4):E6. doi: 10.3171/2023.1.FOCUS22640. Neurosurg Focus. 2023. PMID: 37004136
CONCLUSIONS: This pilot study suggests that activity monitoring provides an early objective measure of improvement in gait entropy after VPS placement among patients with iNPH, although a more significant improvement was noted on the detailed clinical gait assessments. Further lo …
CONCLUSIONS: This pilot study suggests that activity monitoring provides an early objective measure of improvement in gait entropy after VPS …
Conceptualising the episodic nature of disability among adults living with Long COVID: a qualitative study.
O'Brien KK, Brown DA, McDuff K, St Clair-Sullivan N, Solomon P, Chan Carusone S, McCorkell L, Wei H, Goulding S, O'Hara M, Thomson C, Roche N, Stokes R, Vera JH, Erlandson KM, Bergin C, Robinson L, Cheung AM, Torres B, Avery L, Bannan C, Harding R. O'Brien KK, et al. Among authors: brown da. BMJ Glob Health. 2023 Mar;8(3):e011276. doi: 10.1136/bmjgh-2022-011276. BMJ Glob Health. 2023. PMID: 36863719 Free PMC article.
Participants described their disability experiences as episodic in nature, characterised by fluctuations in presence and severity of health-related challenges (disability) that may occur both within a day and over the long-term living with Long COVID. They described living …
Participants described their disability experiences as episodic in nature, characterised by fluctuations in presence and severity of health- …
The neuroprotective effects of estrogen and estrogenic compounds in spinal cord injury.
Shvetcov A, Ruitenberg MJ, Delerue F, Gold WA, Brown DA, Finney CA. Shvetcov A, et al. Among authors: brown da. Neurosci Biobehav Rev. 2023 Mar;146:105074. doi: 10.1016/j.neubiorev.2023.105074. Epub 2023 Feb 2. Neurosci Biobehav Rev. 2023. PMID: 36736846 Free article. Review.
SCI is characterised by multiple injury phases that affect the transmission of sensory and motor signals and lead to temporary or long-term functional deficits. There are few treatments for SCI. Estrogens and estrogenic compounds, however, may effectively mitigate the effe …
SCI is characterised by multiple injury phases that affect the transmission of sensory and motor signals and lead to temporary or long-te …
Unravelling Checkpoint Inhibitor Associated Autoimmune Diabetes: From Bench to Bedside.
Wu L, Tsang VHM, Sasson SC, Menzies AM, Carlino MS, Brown DA, Clifton-Bligh R, Gunton JE. Wu L, et al. Among authors: brown da. Front Endocrinol (Lausanne). 2021 Nov 5;12:764138. doi: 10.3389/fendo.2021.764138. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34803927 Free PMC article. Review.
Among these is beta-cell failure, leading to checkpoint inhibitor-related autoimmune diabetes (CIADM) which entails substantial long-term morbidity. As our understanding of this novel disease grows, parallels and differences between CIADM and classic type 1 diabetes (T1D) …
Among these is beta-cell failure, leading to checkpoint inhibitor-related autoimmune diabetes (CIADM) which entails substantial long-term …
Effect of surgery and chemotherapy on long-term survival in infants with congenital glioblastoma: an integrated survival analysis.
Lu VM, O'Connor KP, Himes BT, Brown DA, Nesvick CL, Siada RG, Niazi TN, Schwartz J, Daniels DJ. Lu VM, et al. Among authors: brown da. J Neurosurg Pediatr. 2020 Aug 14;26(5):563-571. doi: 10.3171/2020.5.PEDS20226. J Neurosurg Pediatr. 2020. PMID: 32796143
Correspondingly, the aim of this study was to present a long-term survivor case from the authors' institution, and establish an integrated cohort of cases across the published literature to better understand the clinical course of this disease in this setting. ...
Correspondingly, the aim of this study was to present a long-term survivor case from the authors' institution, and establish an integ …
A Graded Exposure, Locomotion-Enabled Virtual Reality App During Walking and Reaching for Individuals With Chronic Low Back Pain: Cohort Gaming Design.
Hennessy RW, Rumble D, Christian M, Brown DA, Trost Z. Hennessy RW, et al. Among authors: brown da. JMIR Serious Games. 2020 Aug 10;8(3):e17799. doi: 10.2196/17799. JMIR Serious Games. 2020. PMID: 32773381 Free PMC article.
BACKGROUND: Chronic low back pain (cLBP) can interfere with daily activities, and individuals with elevated pain-related fear (also known as kinesiophobia or the fear of injury due to movement) can develop worse long-term disability. Graded exposure (GEXP) protocols use su …
BACKGROUND: Chronic low back pain (cLBP) can interfere with daily activities, and individuals with elevated pain-related fear (also known as …
35 results