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Page 1
Azole Resistance-Associated Regulatory Motifs within the Promoter of cyp51A in Aspergillus fumigatus.
Kühbacher A, Peiffer M, Hortschansky P, Merschak P, Bromley MJ, Haas H, Brakhage AA, Gsaller F. Kühbacher A, et al. Among authors: bromley mj. Microbiol Spectr. 2022 Jun 29;10(3):e0120922. doi: 10.1128/spectrum.01209-22. Epub 2022 May 16. Microbiol Spectr. 2022. PMID: 35575535 Free PMC article.
We show that promoter occupation by both AtrR and SrbA is required for iron-independent steady-state transcriptional activation of cyp51A and its induction during short-term iron exposure relies on HapX binding. We further reveal the HapX binding site as a repressor elemen …
We show that promoter occupation by both AtrR and SrbA is required for iron-independent steady-state transcriptional activation of cyp51A an …
Contralateral Breast Screening with Preoperative MRI: Long-Term Outcomes for Newly Diagnosed Breast Cancer.
Freitas V, Li X, Amitai Y, Au F, Kulkarni S, Ghai S, Mulligan AM, Bromley M, Siepmann T. Freitas V, et al. Among authors: bromley m. Radiology. 2022 Aug;304(2):297-307. doi: 10.1148/radiol.212361. Epub 2022 Apr 26. Radiology. 2022. PMID: 35471109
Purpose To assess the impact of MRI for screening the contralateral breast on long-term outcomes in patients with newly diagnosed breast cancer and to determine whether subgroups with unfavorable prognoses would benefit from MRI in terms of survival. ...
Purpose To assess the impact of MRI for screening the contralateral breast on long-term outcomes in patients with newly diagnosed bre …
Functional Genomic and Biochemical Analysis Reveals Pleiotropic Effect of Congo Red on Aspergillus fumigatus.
Liu Z, Raj S, van Rhijn N, Fraczek M, Michel JP, Sismeiro O, Legendre R, Varet H, Fontaine T, Bromley M, Latgé JP. Liu Z, et al. Among authors: bromley m. mBio. 2021 May 18;12(3):e00863-21. doi: 10.1128/mBio.00863-21. mBio. 2021. PMID: 34006660 Free PMC article.
Moreover, amorphous surface cell wall polysaccharides such as galactosaminogalactan control the influx of CR inside the cells and, accordingly, resistance to the drug. Finally, long-term incubation with CR led to the discovery of a new CR-induced growth effect, called drug …
Moreover, amorphous surface cell wall polysaccharides such as galactosaminogalactan control the influx of CR inside the cells and, according …
Risk of Adverse Clinical Outcomes in Hyponatremic Adult Patients Hospitalized for Acute Medical Conditions: A Population-Based Cohort Study.
Kutz A, Ebrahimi F, Aghlmandi S, Wagner U, Bromley M, Illigens B, Siepmann T, Schuetz P, Mueller B, Christ-Crain M. Kutz A, et al. Among authors: bromley m. J Clin Endocrinol Metab. 2020 Nov 1;105(11):3428-36. doi: 10.1210/clinem/dgaa547. J Clin Endocrinol Metab. 2020. PMID: 32818232 Free PMC article.
CONTEXT: Hyponatremia has been associated with excess long-term morbidity and mortality. However, effects during hospitalization are poorly studied. ...CONCLUSION: In this study, hyponatremia was associated with increased risk of short-term adverse events, primarily …
CONTEXT: Hyponatremia has been associated with excess long-term morbidity and mortality. However, effects during hospitalization are …
Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression.
Beattie SR, Mark KMK, Thammahong A, Ries LNA, Dhingra S, Caffrey-Carr AK, Cheng C, Black CC, Bowyer P, Bromley MJ, Obar JJ, Goldman GH, Cramer RA. Beattie SR, et al. Among authors: bromley mj. PLoS Pathog. 2017 Apr 19;13(4):e1006340. doi: 10.1371/journal.ppat.1006340. eCollection 2017 Apr. PLoS Pathog. 2017. PMID: 28423062 Free PMC article.
Conceptually, we argue these data provide a foundation for additional studies on fungal factors required to support fungal fitness and disease progression and term such genes and factors, DPFs (disease progression factors)....
Conceptually, we argue these data provide a foundation for additional studies on fungal factors required to support fungal fitness and disea …
Mitochondrial Complex I Is a Global Regulator of Secondary Metabolism, Virulence and Azole Sensitivity in Fungi.
Bromley M, Johns A, Davies E, Fraczek M, Mabey Gilsenan J, Kurbatova N, Keays M, Kapushesky M, Gut M, Gut I, Denning DW, Bowyer P. Bromley M, et al. PLoS One. 2016 Jul 20;11(7):e0158724. doi: 10.1371/journal.pone.0158724. eCollection 2016. PLoS One. 2016. PMID: 27438017 Free PMC article.
Both deletion of the 29.9 KD subunit of complex I and azole treatment alone profoundly change expression of gene clusters involved in secondary metabolism and immunotoxin production raising potential concerns about long term azole therapy....
Both deletion of the 29.9 KD subunit of complex I and azole treatment alone profoundly change expression of gene clusters involved in second …
Design and methodology of SNAP-1: a Sprint National Anaesthesia Project to measure patient reported outcome after anaesthesia.
Moonesinghe SR, Walker EM, Bell M; SNAP-1 Investigator Group. Moonesinghe SR, et al. Perioper Med (Lond). 2015 Apr 17;4:4. doi: 10.1186/s13741-015-0011-2. eCollection 2015. Perioper Med (Lond). 2015. PMID: 25949810 Free PMC article.
Accidental awareness under general anaesthesia (AAGA) is a serious complication of anaesthesia care which may go unrecognised in the immediate perioperative period but leads to long-term psychological harm for affected patients. The SNAP-1 study aimed to measure patient sa …
Accidental awareness under general anaesthesia (AAGA) is a serious complication of anaesthesia care which may go unrecognised in the immedia …
5T4 oncofetal antigen in gastric carcinoma and its clinical significance.
Starzynska T, Wiechowska-Kozlowska A, Marlicz K, Bromley M, Roberts SA, Lawniczak M, Kolodziej B, Zyluk A, Stern PL. Starzynska T, et al. Among authors: bromley m. Eur J Gastroenterol Hepatol. 1998 Jun;10(6):479-84. doi: 10.1097/00042737-199806000-00008. Eur J Gastroenterol Hepatol. 1998. PMID: 9855063
The presence of 5T4 in cancer cells was correlated with poor short-term prognosis (24% vs 49% of 2 year survival for 5T4 positive and negative tumours respectively, P = 0.024). ...CONCLUSIONS: Our results suggest that the assessment of 5T4 expression in gastric carcinoma c …
The presence of 5T4 in cancer cells was correlated with poor short-term prognosis (24% vs 49% of 2 year survival for 5T4 positive and …
Accumulation of p53 in relation to long-term prognosis in colorectal carcinoma.
Starzynska T, Bromley M, Marlicz K, Roberts SA, Ucinski M, Stern PL. Starzynska T, et al. Among authors: bromley m. Eur J Gastroenterol Hepatol. 1997 Feb;9(2):183-6. doi: 10.1097/00042737-199702000-00014. Eur J Gastroenterol Hepatol. 1997. PMID: 9058631
RESULTS: p53 accumulation was detected in 46% (47/102) of the tumours. There was no significant difference in long-term survival between the patients with p53 positive and negative tumours (P=0.86). ...CONCLUSION: The results suggest that in colorectal carcinoma accumulati …
RESULTS: p53 accumulation was detected in 46% (47/102) of the tumours. There was no significant difference in long-term survival betw …
Prognostic significance of p53 overexpression in gastric and colorectal carcinoma.
Starzynska T, Bromley M, Ghosh A, Stern PL. Starzynska T, et al. Among authors: bromley m. Br J Cancer. 1992 Sep;66(3):558-62. doi: 10.1038/bjc.1992.314. Br J Cancer. 1992. PMID: 1520594 Free PMC article.
These studies suggest that in gastric and colorectal carcinoma, immunohistochemical detection of p53 protein in routinely fixed tissue can be used along with other established parameters to assess prognostic outcome, especially to identify patients with poor short-term pro …
These studies suggest that in gastric and colorectal carcinoma, immunohistochemical detection of p53 protein in routinely fixed tissue can b …
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