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A systematic review of antimicrobial therapy in children with tracheostomies.
Pearce H, Talks BJ, Powell S, Brodlie M, Powell J. Pearce H, et al. Among authors: brodlie m. Pediatr Pulmonol. 2024 Feb;59(2):251-259. doi: 10.1002/ppul.26766. Epub 2023 Nov 27. Pediatr Pulmonol. 2024. PMID: 38010838 Review.
Tracheostomies are indicated in children to facilitate long-term ventilatory support, aid in the management of secretions, or manage upper airway obstruction. ...
Tracheostomies are indicated in children to facilitate long-term ventilatory support, aid in the management of secretions, or manage …
Tracheostomy in children is associated with neutrophilic airway inflammation.
Powell J, Powell S, Mather MW, Beck L, Nelson A, Palmowski P, Porter A, Coxhead J, Hedley A, Scott J, Rostron AJ, Hellyer TP, Zaidi F, Davey T, Garnett JP, Agbeko R, Ward C, Stewart CJ, Taggart CC, Brodlie M, Simpson AJ. Powell J, et al. Among authors: brodlie m. Thorax. 2023 Oct;78(10):1019-1027. doi: 10.1136/thorax-2022-219557. Epub 2023 Feb 20. Thorax. 2023. PMID: 36808087 Free PMC article.
RESULTS: Children followed up serially from the time of tracheostomy up to 3 months postprocedure (n=9) were studied. A further cohort of children with a long-term tracheostomy were also enrolled (n=24). Controls (n=13) comprised children without a tracheostomy undergoing …
RESULTS: Children followed up serially from the time of tracheostomy up to 3 months postprocedure (n=9) were studied. A further cohort of ch …
Exploring the impact of elexacaftor-tezacaftor-ivacaftor treatment on opinions regarding airway clearance techniques and nebulisers: TEMPO a qualitative study in children with cystic fibrosis, their families and healthcare professionals.
Almulhem M, Harnett N, Graham S, Haq I, Visram S, Ward C, Brodlie M. Almulhem M, et al. Among authors: brodlie m. BMJ Open Respir Res. 2022 Oct;9(1):e001420. doi: 10.1136/bmjresp-2022-001420. BMJ Open Respir Res. 2022. PMID: 36207030 Free PMC article.
CONCLUSIONS: Despite the highly positive impact of ETI on the health of children with CF some concerns remain about the longer-term outcomes of reducing ACTs or nebulised treatments. ETI has prompted a shift in treatment for many and offers an opportunity to personalise ap …
CONCLUSIONS: Despite the highly positive impact of ETI on the health of children with CF some concerns remain about the longer-term o …
Tracheostomy trends in paediatric intensive care.
Powell J, Buckley HL, Agbeko R, Brodlie M, Powell S. Powell J, et al. Among authors: brodlie m. Arch Dis Child. 2021 Jul;106(7):712-714. doi: 10.1136/archdischild-2020-319396. Epub 2020 Oct 6. Arch Dis Child. 2021. PMID: 33023889
Paediatric tracheostomy is most commonly performed in children on the paediatric intensive care unit (PICU) to facilitate long-term ventilation. We sought to identify trends in UK tracheostomy practice in PICUs. ...
Paediatric tracheostomy is most commonly performed in children on the paediatric intensive care unit (PICU) to facilitate long-term v …
Neutrophils in community-acquired pneumonia: parallels in dysfunction at the extremes of age.
Grudzinska FS, Brodlie M, Scholefield BR, Jackson T, Scott A, Thickett DR, Sapey E. Grudzinska FS, et al. Among authors: brodlie m. Thorax. 2020 Feb;75(2):164-171. doi: 10.1136/thoraxjnl-2018-212826. Epub 2019 Nov 15. Thorax. 2020. PMID: 31732687 Free PMC article. Review.
In children, recurrent pneumonia occurs in approximately 10% of survivors and therefore is a significant cause of healthcare use. Current antibiotic trials focus on short-term outcomes and increasingly shorter courses of antibiotic therapy. ...
In children, recurrent pneumonia occurs in approximately 10% of survivors and therefore is a significant cause of healthcare use. Current an …
Pediatric tracheostomy: A large single-center experience.
Roberts J, Powell J, Begbie J, Siou G, McLarnon C, Welch A, McKean M, Thomas M, Ebdon AM, Moss S, Agbeko RS, Smith JH, Brodlie M, O'Brien C, Powell S. Roberts J, et al. Among authors: brodlie m. Laryngoscope. 2020 May;130(5):E375-E380. doi: 10.1002/lary.28160. Epub 2019 Jun 28. Laryngoscope. 2020. PMID: 31251404
RESULTS: One hundred seventy-two pediatric tracheostomies were performed during the study period with a median age of 141 (interquartile range [IQR] 51-484) days. The most common primary indication was long-term ventilation (38.4%, 66 of 172), followed by weaning from vent …
RESULTS: One hundred seventy-two pediatric tracheostomies were performed during the study period with a median age of 141 (interquartile ran …
Ataluren in cystic fibrosis: development, clinical studies and where are we now?
Zainal Abidin N, Haq IJ, Gardner AI, Brodlie M. Zainal Abidin N, et al. Among authors: brodlie m. Expert Opin Pharmacother. 2017 Sep;18(13):1363-1371. doi: 10.1080/14656566.2017.1359255. Epub 2017 Aug 1. Expert Opin Pharmacother. 2017. PMID: 28730885 Review.
We review clinical studies that have been performed involving ataluren in CF. Early-phase short-term cross-over studies showed improvement in nasal potential difference. ...
We review clinical studies that have been performed involving ataluren in CF. Early-phase short-term cross-over studies showed improv …
Congenital Lung Agenesis: Incidence and Outcome in the North of England.
Robertson N, Miller N, Rankin J, McKean M, Brodlie M, Thomas M. Robertson N, et al. Among authors: brodlie m. Birth Defects Res. 2017 Jul 3;109(11):857-859. doi: 10.1002/bdr2.1011. Epub 2017 Apr 12. Birth Defects Res. 2017. PMID: 28402072
Long-term prognosis with modern management remains unknown, and the potential for the development of pulmonary hypertension remains a concern. Birth Defects Research 109:857-859, 2017. 2017 Wiley Periodicals, Inc....
Long-term prognosis with modern management remains unknown, and the potential for the development of pulmonary hypertension remains a …
Use of somatostatin analogues to treat chylothorax in a child with Generalised Lymphatic Dysplasia.
Brodlie M, Abdelgalil S, Mansour S, Spencer DA. Brodlie M, et al. Respir Med Case Rep. 2012;5:76-7. doi: 10.1016/j.rmedc.2011.07.005. Epub 2011 Oct 1. Respir Med Case Rep. 2012. PMID: 26056769 Free PMC article.
A clinical diagnosis of Generalised Lymphatic Dysplasia was made and long-term treatment with somatostatin analogues (somatostatin initially followed by monthly octreotide) was initiated. ...
A clinical diagnosis of Generalised Lymphatic Dysplasia was made and long-term treatment with somatostatin analogues (somatostatin in …