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Non-invasive ventilation is associated with long-term improvements in lung function and gas exchange in cystic fibrosis adults with hypercapnic respiratory failure.
Wadsworth LE, Belcher J, Bright-Thomas RJ. Wadsworth LE, et al. Among authors: bright thomas rj. J Cyst Fibros. 2021 Sep;20(5):e40-e45. doi: 10.1016/j.jcf.2021.05.011. Epub 2021 Jun 16. J Cyst Fibros. 2021. PMID: 34140250 Free article.
BACKGROUND: Non-invasive ventilation (NIV) is an established treatment option for cystic fibrosis (CF) patients with type 2 respiratory failure but the benefits of this therapy remain unclear. This study examined the long-term outcomes and response to NIV in a large adult …
BACKGROUND: Non-invasive ventilation (NIV) is an established treatment option for cystic fibrosis (CF) patients with type 2 respiratory fail …
Therapeutic mammaplasty is a safe and effective alternative to mastectomy with or without immediate breast reconstruction.
Potter S, Trickey A, Rattay T, O'Connell RL, Dave R, Baker E, Whisker L, Skillman J, Gardiner MD, Macmillan RD, Holcombe C; TeaM and iBRA-2 Steering Groups, the Breast Reconstruction Research Collaborative, and the Mammary Fold Academic and Research Collaborative. Potter S, et al. Br J Surg. 2020 Jun;107(7):832-844. doi: 10.1002/bjs.11468. Epub 2020 Feb 19. Br J Surg. 2020. PMID: 32073654
BACKGROUND: Therapeutic mammaplasty (TM) may be an alternative to mastectomy, but few well designed studies have evaluated the success of this approach or compared the short-term outcomes of TM with mastectomy with or without immediate breast reconstruction (IBR). ...Furth …
BACKGROUND: Therapeutic mammaplasty (TM) may be an alternative to mastectomy, but few well designed studies have evaluated the success of th …
Lessons of the month 1: Salbutamol induced lactic acidosis: clinically recognised but often forgotten.
Pearmain L, Gupta R, Bright-Thomas RJ. Pearmain L, et al. Among authors: bright thomas rj. Clin Med (Lond). 2020 Jan;20(1):101-104. doi: 10.7861/clinmed.2019-0271. Clin Med (Lond). 2020. PMID: 31941741 Free PMC article.
In addition to maintenance inhaled therapy, the patient was also on long-term mirtazapine and furosemide. Following acute treatment with nebulised salbutamol she became increasingly dyspnoeic and developed a metabolic acidosis with a significantly raised blood lactate leve …
In addition to maintenance inhaled therapy, the patient was also on long-term mirtazapine and furosemide. Following acute treatment w …
Short-term safety outcomes of mastectomy and immediate implant-based breast reconstruction with and without mesh (iBRA): a multicentre, prospective cohort study.
Potter S, Conroy EJ, Cutress RI, Williamson PR, Whisker L, Thrush S, Skillman J, Barnes NLP, Mylvaganam S, Teasdale E, Jain A, Gardiner MD, Blazeby JM, Holcombe C; iBRA Steering Group; Breast Reconstruction Research Collaborative. Potter S, et al. Lancet Oncol. 2019 Feb;20(2):254-266. doi: 10.1016/S1470-2045(18)30781-2. Epub 2019 Jan 9. Lancet Oncol. 2019. PMID: 30639093 Free PMC article.
BACKGROUND: Use of biological or synthetic mesh might improve outcomes of immediate implant-based breast reconstruction-breast reconstruction with implants or expanders at the time of mastectomy-but there is a lack of high-quality evidence to support the safety or effectiveness o …
BACKGROUND: Use of biological or synthetic mesh might improve outcomes of immediate implant-based breast reconstruction-breast reconstructio …
Current practice and short-term outcomes of therapeutic mammaplasty in the international TeaM multicentre prospective cohort study.
O'Connell RL, Baker E, Trickey A, Rattay T, Whisker L, Macmillan RD, Potter S; TeaM Steering Group; Mammary Fold Academic and Research Collaborative. O'Connell RL, et al. Br J Surg. 2018 Dec;105(13):1778-1792. doi: 10.1002/bjs.10959. Epub 2018 Aug 22. Br J Surg. 2018. PMID: 30132807
This prospective multicentre cohort study aimed to explore the practice and short-term outcomes of the technique. METHODS: Consecutive patients undergoing therapeutic mammaplasty at participating centres between 1 September 2016 and 30 June 2017 were recruited to the study …
This prospective multicentre cohort study aimed to explore the practice and short-term outcomes of the technique. METHODS: Consecutiv …
What is the role of noninvasive ventilation in cystic fibrosis?
Bright-Thomas RJ, Johnson SC. Bright-Thomas RJ, et al. Curr Opin Pulm Med. 2014 Nov;20(6):618-22. doi: 10.1097/MCP.0000000000000105. Curr Opin Pulm Med. 2014. PMID: 25225790 Review.
RECENT FINDINGS: Noninvasive ventilation was originally reported as a bridge to transplantation in CF patients with severe respiratory failure but is now used as a long-term treatment modality for patients with respiratory failure independent of transplant status. ...
RECENT FINDINGS: Noninvasive ventilation was originally reported as a bridge to transplantation in CF patients with severe respiratory failu …
Aspergillus bronchitis without significant immunocompromise.
Chrdle A, Mustakim S, Bright-Thomas RJ, Baxter CG, Felton T, Denning DW. Chrdle A, et al. Among authors: bright thomas rj. Ann N Y Acad Sci. 2012 Dec;1272:73-85. doi: 10.1111/j.1749-6632.2012.06816.x. Ann N Y Acad Sci. 2012. PMID: 23231717
Six of 12 (50%) had a major response to antifungal therapy and five of 12 (42%) patients relapsed, requiring long-term therapy. Aspergillus bronchitis is a discrete clinical entity in patients with structural lung disease but who are not significantly immunocompromised. .. …
Six of 12 (50%) had a major response to antifungal therapy and five of 12 (42%) patients relapsed, requiring long-term therapy. Asper …
Pulmonary artery pressure in cystic fibrosis adults: characteristics, clinical correlates and long-term follow-up.
Bright-Thomas RJ, Ray SG, Webb AK. Bright-Thomas RJ, et al. J Cyst Fibros. 2012 Dec;11(6):532-8. doi: 10.1016/j.jcf.2012.04.012. Epub 2012 May 25. J Cyst Fibros. 2012. PMID: 22633126 Free article.
BACKGROUND: We examined pulmonary artery pressure (PAP) characteristics of CF adults, studied clinical correlates and long-term survival. METHODS: Comprehensive clinical data were collected and Doppler echocardiography was used to estimate PAP in 109 stable CF adults and 5 …
BACKGROUND: We examined pulmonary artery pressure (PAP) characteristics of CF adults, studied clinical correlates and long-term survi …
Effectiveness of 3 months of rifampicin and isoniazid chemoprophylaxis for the treatment of latent tuberculosis infection in children.
Bright-Thomas R, Nandwani S, Smith J, Morris JA, Ormerod LP. Bright-Thomas R, et al. Arch Dis Child. 2010 Aug;95(8):600-2. doi: 10.1136/adc.2010.182600. Epub 2010 Jun 7. Arch Dis Child. 2010. PMID: 20530147
The efficacy of this regimen in children in the UK has only been studied indirectly. The long-term outcome of those children treated with 3RH, in the Chest Clinic of this high tuberculosis (TB) incidence district, has been studied to derive a more direct assessment of effe …
The efficacy of this regimen in children in the UK has only been studied indirectly. The long-term outcome of those children treated …