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Effects of sugars, fatty acids and amino acids on cytosolic and mitochondrial hydrogen peroxide release from liver cells.
Fang J, Zhang Y, Gerencser AA, Brand MD. Fang J, et al. Among authors: brand md. Free Radic Biol Med. 2022 Aug 1;188:92-102. doi: 10.1016/j.freeradbiomed.2022.06.225. Epub 2022 Jun 16. Free Radic Biol Med. 2022. PMID: 35716827 Free PMC article.
Glucose supplementation also restored ATP production and mitochondrial NAD reduction level, suggesting that the increased rates of hydrogen peroxide release from the mitochondrial sites were driven by increases in the protonmotive force and the degree of reduction of the electron …
Glucose supplementation also restored ATP production and mitochondrial NAD reduction level, suggesting that the increased rates of hydrogen …
Mitochondrial bioenergetics and neuronal survival modelled in primary neuronal culture and isolated nerve terminals.
Nicholls DG, Brand MD, Gerencser AA. Nicholls DG, et al. Among authors: brand md. J Bioenerg Biomembr. 2015 Apr;47(1-2):63-74. doi: 10.1007/s10863-014-9573-9. Epub 2014 Aug 30. J Bioenerg Biomembr. 2015. PMID: 25172197 Review.
Mitochondria play multiple roles in the maintenance of neuronal function under physiological and pathological conditions. In addition to ATP generation, they can act as major short-term calcium sinks and can both generate, and be damaged by, reactive oxygen species. ...
Mitochondria play multiple roles in the maintenance of neuronal function under physiological and pathological conditions. In addition to ATP …
Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis.
Lelliott CJ, López M, Curtis RK, Parker N, Laudes M, Yeo G, Jimenez-Liñan M, Grosse J, Saha AK, Wiggins D, Hauton D, Brand MD, O'Rahilly S, Griffin JL, Gibbons GF, Vidal-Puig A. Lelliott CJ, et al. Among authors: brand md. FASEB J. 2005 Jul;19(9):1108-19. doi: 10.1096/fj.04-3196com. FASEB J. 2005. PMID: 15985534
Tamoxifen, (TMX) a widely used anti-breast cancer drug, can induce NASH and changes in plasma cholesterol levels through mechanisms that are unclear. We studied primary actions of TMX using a short-term treatment (5 days) that induces microvesicular hepatic steatosis and m …
Tamoxifen, (TMX) a widely used anti-breast cancer drug, can induce NASH and changes in plasma cholesterol levels through mechanisms that are …
Processes contributing to metabolic depression in hepatopancreas cells from the snail Helix aspersa.
Bishop T, Brand MD. Bishop T, et al. Among authors: brand md. J Exp Biol. 2000 Dec;203(Pt 23):3603-12. doi: 10.1242/jeb.203.23.3603. J Exp Biol. 2000. PMID: 11060221
Cells isolated from the hepatopancreas of the land snail Helix aspersa strongly depress respiration both immediately in response to lowered P(O2) (oxygen conformation) and, in the longer term, during aestivation. These phenomena were analysed by dividing cellular respirati …
Cells isolated from the hepatopancreas of the land snail Helix aspersa strongly depress respiration both immediately in response to lowered …
Effects of the mitogen concanavalin A on pathways of thymocyte energy metabolism.
Krauss S, Buttgereit F, Brand MD. Krauss S, et al. Among authors: brand md. Biochim Biophys Acta. 1999 Jun 30;1412(2):129-38. doi: 10.1016/s0005-2728(99)00058-4. Biochim Biophys Acta. 1999. PMID: 10393256 Free article.
It stimulates the energy metabolism of thymocytes within seconds of exposure. We studied short-term effects (<30 min) of Con A on a conceptually simplified model system of rat thymocyte energy metabolism in the concentration range of 0-2 microg Con A per 107 cells, usin …
It stimulates the energy metabolism of thymocytes within seconds of exposure. We studied short-term effects (<30 min) of Con A on …
The causes and functions of mitochondrial proton leak.
Brand MD, Chien LF, Ainscow EK, Rolfe DF, Porter RK. Brand MD, et al. Biochim Biophys Acta. 1994 Aug 30;1187(2):132-9. doi: 10.1016/0005-2728(94)90099-x. Biochim Biophys Acta. 1994. PMID: 8075107 Review.
Changes in proton leak in tissues are brought about in the short term by changes in mitochondrial protonmotive force and in the longer term by changes in the surface area and proton permeability of the mitochondrial inner membrane. ...
Changes in proton leak in tissues are brought about in the short term by changes in mitochondrial protonmotive force and in the longe …
Effects of methylprednisolone on the energy metabolism of quiescent and ConA-stimulated thymocytes of the rat.
Buttgereit F, Brand MD, Müller M. Buttgereit F, et al. Among authors: brand md. Biosci Rep. 1993 Feb;13(1):41-52. doi: 10.1007/BF01138177. Biosci Rep. 1993. PMID: 7687156
The short-term effects of high concentrations of Methylprednisolone (MP) on the energy metabolism of quiescent and Concanavalin A-stimulated rat thymocytes were investigated in vitro. ...
The short-term effects of high concentrations of Methylprednisolone (MP) on the energy metabolism of quiescent and Concanavalin A-sti …
Control of hepatic mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase during the foetal/neonatal transition, suckling and weaning in the rat.
Quant PA, Robin D, Robin P, Ferre P, Brand MD, Girard J. Quant PA, et al. Among authors: brand md. Eur J Biochem. 1991 Jan 30;195(2):449-54. doi: 10.1111/j.1432-1033.1991.tb15724.x. Eur J Biochem. 1991. PMID: 1671765 Free article.
(1) We assayed active and total (i.e. active plus succinylated) 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase in mitochondria isolated from foetal, neonatal, suckling or weaned rats. (2) HMG-CoA synthase was substantially succinylated and inactivated in mitochondria isolated …
(1) We assayed active and total (i.e. active plus succinylated) 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase in mitochondria isolated f …