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Homeostatic Function and Inflammatory Activation of Ileal CD8+ Tissue-Resident T Cells Is Dependent on Mucosal Location.
Lutter L, Roosenboom B, Brand EC, Ter Linde JJ, Oldenburg B, van Lochem EG, Horjus Talabur Horje CS, van Wijk F. Lutter L, et al. Among authors: brand ec. Cell Mol Gastroenterol Hepatol. 2021;12(5):1567-1581. doi: 10.1016/j.jcmgh.2021.06.022. Epub 2021 Jul 2. Cell Mol Gastroenterol Hepatol. 2021. PMID: 34224909 Free PMC article.
CONCLUSIONS: Altogether, these compartmental and inflammation-induced differences indicate that therapeutic strategies could have a different impact on the same immune cells depending on the local compartment and presence of an inflammatory milieu, and should be taken into accoun …
CONCLUSIONS: Altogether, these compartmental and inflammation-induced differences indicate that therapeutic strategies could have a differen …
Sex-specific differences and long-term outcome of patients with coronary artery disease and chronic kidney disease: the Coronary Artery Disease and Renal Failure (CAD-REF) Registry.
Engelbertz C, Pinnschmidt HO, Freisinger E, Reinecke H, Schmitz B, Fobker M, Schmieder RE, Wegscheider K, Breithardt G, Pavenstädt H, Brand E. Engelbertz C, et al. Among authors: brand e. Clin Res Cardiol. 2021 Oct;110(10):1625-1636. doi: 10.1007/s00392-021-01864-5. Epub 2021 May 26. Clin Res Cardiol. 2021. PMID: 34036426 Free PMC article.
BACKGROUND: Cardiovascular morbidity and mortality are closely linked to chronic kidney disease (CKD). Sex-specific long-term outcome data of patients with coronary artery disease (CAD) and CKD are scarce. ...Cox-regression analysis revealed that sex or multivessel coronar …
BACKGROUND: Cardiovascular morbidity and mortality are closely linked to chronic kidney disease (CKD). Sex-specific long-term outcome …
Detailed epitope mapping of neutralizing anti-drug antibodies against recombinant α-galactosidase A in patients with Fabry disease.
Scharnetzki D, Stappers F, Lenders M, Brand E. Scharnetzki D, et al. Among authors: brand e. Mol Genet Metab. 2020 Sep-Oct;131(1-2):229-234. doi: 10.1016/j.ymgme.2020.08.005. Epub 2020 Aug 28. Mol Genet Metab. 2020. PMID: 32888778
A subset of 20 patients was analyzed to assess if NAGA-recognizing ADAs against AGAL might affect long-term outcomes under ERT. RESULTS: Thirty percent of the AGAL active site was recognized by patients' ADAs. ...
A subset of 20 patients was analyzed to assess if NAGA-recognizing ADAs against AGAL might affect long-term outcomes under ERT. RESUL …
Cardiomyopathy and kidney function in agalsidase beta-treated female Fabry patients: a pre-treatment vs. post-treatment analysis.
Wanner C, Feldt-Rasmussen U, Jovanovic A, Linhart A, Yang M, Ponce E, Brand E, Germain DP, Hughes DA, Jefferies JL, Martins AM, Nowak A, Vujkovac B, Weidemann F, West ML, Ortiz A. Wanner C, et al. Among authors: brand e. ESC Heart Fail. 2020 Jun;7(3):825-834. doi: 10.1002/ehf2.12647. Epub 2020 Feb 26. ESC Heart Fail. 2020. PMID: 32100468 Free PMC article.
AIMS: Long-term treatment effect studies in large female Fabry patient groups are challenging to design because of phenotype heterogeneity and lack of appropriate comparison groups, and have not been reported. We compared long-term cardiomyopathy and kidney function …
AIMS: Long-term treatment effect studies in large female Fabry patient groups are challenging to design because of phenotype heteroge …
FAbry STabilization indEX (FASTEX): Clinical evaluation of disease progression in Fabry patients.
Lenders M, Brand E. Lenders M, et al. Among authors: brand e. Mol Genet Metab. 2020 Feb;129(2):142-149. doi: 10.1016/j.ymgme.2019.12.010. Epub 2019 Dec 18. Mol Genet Metab. 2020. PMID: 31879214
Longitudinal analysis suggested a stable disease course using DS3 and MSSI. Only males long-term-treated with agalsidase-alfa presented with a slight increase of the general MSSI score (p = .0084). ...CONCLUSION: We conclude that the FASTEX seems to be a simple and user fr …
Longitudinal analysis suggested a stable disease course using DS3 and MSSI. Only males long-term-treated with agalsidase-alfa present …
Impact of immunosuppressive therapy on therapy-neutralizing antibodies in transplanted patients with Fabry disease.
Lenders M, Oder D, Nowak A, Canaan-Kühl S, Arash-Kaps L, Drechsler C, Schmitz B, Nordbeck P, Hennermann JB, Kampmann C, Reuter S, Brand SM, Wanner C, Brand E. Lenders M, et al. Among authors: brand e. J Intern Med. 2017 Sep;282(3):241-253. doi: 10.1111/joim.12647. Epub 2017 Jul 26. J Intern Med. 2017. PMID: 28682471 Free article.
METHODS: In this retrospective study, we investigated the effect of long-term immunosuppression on ERT inhibition in male patients with FD (n = 26) receiving immunosuppressive therapy due to kidney (n = 24) or heart (n = 2) transplantation. ...Intensified high dosages of i …
METHODS: In this retrospective study, we investigated the effect of long-term immunosuppression on ERT inhibition in male patients wi …
Cannabis in Chinese Medicine: Are Some Traditional Indications Referenced in Ancient Literature Related to Cannabinoids?
Brand EJ, Zhao Z. Brand EJ, et al. Front Pharmacol. 2017 Mar 10;8:108. doi: 10.3389/fphar.2017.00108. eCollection 2017. Front Pharmacol. 2017. PMID: 28344554 Free PMC article. Review.
Furthermore, many key questions remain unresolved in the Chinese literature, including how various traditional drug names precisely correspond to different plant parts, as well as the implications of long-term selection for fiber-rich cultivars on the medical applications …
Furthermore, many key questions remain unresolved in the Chinese literature, including how various traditional drug names precisely correspo …
Renal function predicts long-term outcome on enzyme replacement therapy in patients with Fabry disease.
Lenders M, Schmitz B, Stypmann J, Duning T, Brand SM, Kurschat C, Brand E. Lenders M, et al. Among authors: brand e. Nephrol Dial Transplant. 2017 Dec 1;32(12):2090-2097. doi: 10.1093/ndt/gfw334. Nephrol Dial Transplant. 2017. PMID: 27679524
We analysed the incidence of FD-related renal, cardiac and neurologic end points in patients with FD on long-term enzyme replacement therapy (ERT). METHODS: A retrospective analysis of prospectively collected data from two German FD centres was performed. ...
We analysed the incidence of FD-related renal, cardiac and neurologic end points in patients with FD on long-term enzyme replacement …
Elevated copeptin is a prognostic factor for mortality even in patients with renal dysfunction.
Engelbertz C, Brand E, Fobker M, Fischer D, Pavenstädt H, Reinecke H. Engelbertz C, et al. Among authors: brand e. Int J Cardiol. 2016 Oct 15;221:327-32. doi: 10.1016/j.ijcard.2016.07.058. Epub 2016 Jul 5. Int J Cardiol. 2016. PMID: 27404700
CONCLUSION: Elevated copeptin can be used as a valuable prognostic factor for intermediate-term mortality in patients with both coronary artery and renal disease....
CONCLUSION: Elevated copeptin can be used as a valuable prognostic factor for intermediate-term mortality in patients with both coron …
[Inheritance and innovation of traditional Chinese medicinal authentication].
Zhao ZZ, Chen HB, Xiao PG, Guo P, Liang ZT, Hung F, Wong LL, Brand E, Liu J. Zhao ZZ, et al. Among authors: brand e. Zhongguo Zhong Yao Za Zhi. 2015 Sep;40(17):3385-90. Zhongguo Zhong Yao Za Zhi. 2015. PMID: 26978977 Chinese.
Chinese medicinal authentication has both scientific and traditional cultural connotations; the use of scientific methods to elucidate traditional experience-based differentiation carries the legacy of Chinese medicine forward, and offers immediate practical significance and long …
Chinese medicinal authentication has both scientific and traditional cultural connotations; the use of scientific methods to elucidate tradi …
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