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Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis.
Raddassi K, Kent SC, Yang J, Bourcier K, Bradshaw EM, Seyfert-Margolis V, Nepom GT, Kwok WW, Hafler DA. Raddassi K, et al. Among authors: bradshaw em. J Immunol. 2011 Jul 15;187(2):1039-46. doi: 10.4049/jimmunol.1001543. Epub 2011 Jun 8. J Immunol. 2011. PMID: 21653833 Free PMC article. Clinical Trial.
MOG(97-109)-reactive CD4(+) T cells, isolated with DRB1*0401/MOG(97-109) tetramers, and after a short-term culture of PMBCs with MOG(97-109) peptides, were detected more frequently from patients with MS as compared with healthy controls. ...
MOG(97-109)-reactive CD4(+) T cells, isolated with DRB1*0401/MOG(97-109) tetramers, and after a short-term culture of PMBCs with MOG( …
Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells.
Bradshaw EM, Raddassi K, Elyaman W, Orban T, Gottlieb PA, Kent SC, Hafler DA. Bradshaw EM, et al. J Immunol. 2009 Oct 1;183(7):4432-9. doi: 10.4049/jimmunol.0900576. Epub 2009 Sep 11. J Immunol. 2009. PMID: 19748982 Free PMC article.
In this study, we report a significant although modest increase in the frequency of IL-17-secreting cells in lymphocytes from long-term patients with T1D compared with healthy controls. These data suggest that the innate immune system in T1D may drive the adaptive immune s …
In this study, we report a significant although modest increase in the frequency of IL-17-secreting cells in lymphocytes from long-term …