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Multiple decades of stocking has resulted in limited hatchery introgression in wild brook trout (Salvelinus fontinalis) populations of Nova Scotia.
Lehnert SJ, Baillie SM, MacMillan J, Paterson IG, Buhariwalla CF, Bradbury IR, Bentzen P. Lehnert SJ, et al. Among authors: bradbury ir. Evol Appl. 2020 Feb 20;13(5):1069-1089. doi: 10.1111/eva.12923. eCollection 2020 May. Evol Appl. 2020. PMID: 32431753 Free PMC article.
Many populations of freshwater fishes are threatened with losses, and increasingly, the release of hatchery individuals is one strategy being implemented to support wild populations. However, stocking of hatchery individuals may pose long-term threats to wild populations, …
Many populations of freshwater fishes are threatened with losses, and increasingly, the release of hatchery individuals is one strategy bein …
Are we assuming too much with our statistical assumptions? Lessons learned from the ALTTO trial.
Holmes EM, Bradbury I, Williams LS, Korde L, de Azambuja E, Fumagalli D, Moreno-Aspitia A, Baselga J, Piccart-Gebhart M, Dueck AC, Gelber RD; ALTTO Trial Study Team. Holmes EM, et al. Among authors: bradbury i. Ann Oncol. 2019 Sep 1;30(9):1507-1513. doi: 10.1093/annonc/mdz195. Ann Oncol. 2019. PMID: 31240310 Free PMC article. Clinical Trial.
RESULTS AND CONCLUSIONS: We conclude that (i) futility stopping rules are important to protect patient safety, but stopping early for efficacy can be misleading as short-term results may not imply long-term efficacy, (ii) biologically important differences between s …
RESULTS AND CONCLUSIONS: We conclude that (i) futility stopping rules are important to protect patient safety, but stopping early for effica …
Estimating the relative fitness of escaped farmed salmon offspring in the wild and modelling the consequences of invasion for wild populations.
Sylvester EVA, Wringe BF, Duffy SJ, Hamilton LC, Fleming IA, Castellani M, Bentzen P, Bradbury IR. Sylvester EVA, et al. Among authors: bradbury ir. Evol Appl. 2019 Jan 28;12(4):705-717. doi: 10.1111/eva.12746. eCollection 2019 Apr. Evol Appl. 2019. PMID: 30976304 Free PMC article.
These relative survivorship estimates were used to inform an individual-based salmon eco-genetic model to project changes in adult abundance and overall allele frequency across three invasion scenarios ranging from short-term to long-term invasion and three relative …
These relative survivorship estimates were used to inform an individual-based salmon eco-genetic model to project changes in adult abundance …
Evolutionary genetics of immunological supertypes reveals two faces of the Red Queen.
Lighten J, Papadopulos AST, Mohammed RS, Ward BJ, G Paterson I, Baillie L, Bradbury IR, Hendry AP, Bentzen P, van Oosterhout C. Lighten J, et al. Among authors: bradbury ir. Nat Commun. 2017 Nov 3;8(1):1294. doi: 10.1038/s41467-017-01183-2. Nat Commun. 2017. PMID: 29101318 Free PMC article.
Red Queen host-parasite co-evolution can drive adaptations of immune genes by positive selection that erodes genetic variation (Red Queen arms race) or results in a balanced polymorphism (Red Queen dynamics) and long-term preservation of genetic variation (trans-species po …
Red Queen host-parasite co-evolution can drive adaptations of immune genes by positive selection that erodes genetic variation (Red Queen ar …
Trans-oceanic genomic divergence of Atlantic cod ecotypes is associated with large inversions.
Berg PR, Star B, Pampoulie C, Bradbury IR, Bentzen P, Hutchings JA, Jentoft S, Jakobsen KS. Berg PR, et al. Among authors: bradbury ir. Heredity (Edinb). 2017 Dec;119(6):418-428. doi: 10.1038/hdy.2017.54. Epub 2017 Sep 20. Heredity (Edinb). 2017. PMID: 28930288 Free PMC article.
The occurrence of these inversions on both sides of the Atlantic Ocean reveals a common evolutionary origin, predating the >100 000-year-old trans-Atlantic separation of Atlantic cod. The long-term persistence of these inversions indicates that they are maintained by se …
The occurrence of these inversions on both sides of the Atlantic Ocean reveals a common evolutionary origin, predating the >100 000-year- …
Genomic evidence of hybridization between two independent invasions of European green crab (Carcinus maenas) in the Northwest Atlantic.
Jeffery NW, DiBacco C, Wringe BF, Stanley RRE, Hamilton LC, Ravindran PN, Bradbury IR. Jeffery NW, et al. Among authors: bradbury ir. Heredity (Edinb). 2017 Sep;119(3):154-165. doi: 10.1038/hdy.2017.22. Epub 2017 Apr 19. Heredity (Edinb). 2017. PMID: 28422135 Free PMC article.
Invasive species have been associated with significant negative impacts in their introduced range often outcompeting native species, yet the long-term evolutionary dynamics of biological invasions are not well understood. ...
Invasive species have been associated with significant negative impacts in their introduced range often outcompeting native species, yet the …
RNA Sequencing to Predict Response to Neoadjuvant Anti-HER2 Therapy: A Secondary Analysis of the NeoALTTO Randomized Clinical Trial.
Fumagalli D, Venet D, Ignatiadis M, Azim HA Jr, Maetens M, Rothé F, Salgado R, Bradbury I, Pusztai L, Harbeck N, Gomez H, Chang TW, Coccia-Portugal MA, Di Cosimo S, de Azambuja E, de la Peña L, Nuciforo P, Brase JC, Huober J, Baselga J, Piccart M, Loi S, Sotiriou C. Fumagalli D, et al. Among authors: bradbury i. JAMA Oncol. 2017 Feb 1;3(2):227-234. doi: 10.1001/jamaoncol.2016.3824. JAMA Oncol. 2017. PMID: 27684533 Free PMC article.
MAIN OUTCOMES AND MEASURES: Gene expression-based biomarkers using RNA sequencing were examined for their association with response to anti-HER2 therapy and long-term outcome. RESULTS: Sequencing data were available for 254 (56%) of the NeoALTTO participants (mean [SD] age …
MAIN OUTCOMES AND MEASURES: Gene expression-based biomarkers using RNA sequencing were examined for their association with response to anti- …
parallelnewhybrid: an R package for the parallelization of hybrid detection using newhybrids.
Wringe BF, Stanley RR, Jeffery NW, Anderson EC, Bradbury IR. Wringe BF, et al. Among authors: bradbury ir. Mol Ecol Resour. 2017 Jan;17(1):91-95. doi: 10.1111/1755-0998.12597. Epub 2016 Oct 1. Mol Ecol Resour. 2017. PMID: 27617417
We show that parallelization of analyses using this package affords users several-fold reductions in time over a traditional serial analysis. parallelnewhybrid consists of an example data set, a readme and three operating system-specific functions to execute parallel newhybrids a …
We show that parallelization of analyses using this package affords users several-fold reductions in time over a traditional serial analysis …
Low residual proliferation after short-term letrozole therapy is an early predictive marker of response in high proliferative ER-positive breast cancer.
Bedard PL, Singhal SK, Ignatiadis M, Bradbury I, Haibe-Kains B, Desmedt C, Loi S, Evans DB, Michiels S, Dixon JM, Miller WR, Piccart MJ, Sotiriou C. Bedard PL, et al. Among authors: bradbury i. Endocr Relat Cancer. 2011 Nov 14;18(6):721-30. doi: 10.1530/ERC-11-0180. Print 2011 Dec. Endocr Relat Cancer. 2011. PMID: 21984694
The major conclusion of this study is that the early assessment of proliferation after short-term endocrine therapy may be useful to evaluate endocrine responsiveness, particularly in genomic high-grade ER-positive breast cancer....
The major conclusion of this study is that the early assessment of proliferation after short-term endocrine therapy may be useful to …
Cross-trimester repeated measures testing for Down's syndrome screening: an assessment.
Wright D, Bradbury I, Malone F, D'Alton M, Summers A, Huang T, Ball S, Baker A, Nix B, Aitken D, Crossley J, Cuckle H, Spencer K. Wright D, et al. Among authors: bradbury i. Health Technol Assess. 2010 Jul;14(33):1-80. doi: 10.3310/hta14330. Health Technol Assess. 2010. PMID: 20624355 Free article.
MAIN OUTCOME MEASURES: Detection and false-positive rates for screening with a threshold risk of 1 in 200 at term, and the detection rate achieved for a false-positive rate of 2%. ...
MAIN OUTCOME MEASURES: Detection and false-positive rates for screening with a threshold risk of 1 in 200 at term, and the detection …
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