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CFTR modulator theratyping: Current status, gaps and future directions.
Clancy JP, Cotton CU, Donaldson SH, Solomon GM, VanDevanter DR, Boyle MP, Gentzsch M, Nick JA, Illek B, Wallenburg JC, Sorscher EJ, Amaral MD, Beekman JM, Naren AP, Bridges RJ, Thomas PJ, Cutting G, Rowe S, Durmowicz AG, Mense M, Boeck KD, Skach W, Penland C, Joseloff E, Bihler H, Mahoney J, Borowitz D, Tuggle KL. Clancy JP, et al. Among authors: boyle mp. J Cyst Fibros. 2019 Jan;18(1):22-34. doi: 10.1016/j.jcf.2018.05.004. Epub 2018 Jun 20. J Cyst Fibros. 2019. PMID: 29934203 Free PMC article. Review.
The theme of the workshop was centered on CFTR theratyping, a term that encompasses the use of CFTR modulators to define defects in CFTR in vitro, with application to both common and rare CFTR variants. ...
The theme of the workshop was centered on CFTR theratyping, a term that encompasses the use of CFTR modulators to define defects in C …
Temperature sensitivity of capillary-driven flow: application to age monitoring devices.
Thomas JA, Boyle MP, Hunter LW, Tiffany JE. Thomas JA, et al. Among authors: boyle mp. J Colloid Interface Sci. 2012 Apr 15;372(1):176-82. doi: 10.1016/j.jcis.2012.01.008. Epub 2012 Jan 20. J Colloid Interface Sci. 2012. PMID: 22300654
This model is used to examine how temperature excursions affect the instantaneous and long-term position and velocity of the fluid front inside the capillary. ...
This model is used to examine how temperature excursions affect the instantaneous and long-term position and velocity of the fluid fr …
Self-reported experience of bullying of students who stutter: relations with life satisfaction, life orientation, and self-esteem.
Blood GW, Blood IM, Tramontana GM, Sylvia AJ, Boyle MP, Motzko GR. Blood GW, et al. Among authors: boyle mp. Percept Mot Skills. 2011 Oct;113(2):353-64. doi: 10.2466/07.10.15.17.PMS.113.5.353-364. Percept Mot Skills. 2011. PMID: 22185050
Given the increased likelihood of students who stuttered being bullied, the negative relation of adjustment variables and bullying, and the potentially negative long-term effects of bullying, increased vigilance and early intervention are discussed....
Given the increased likelihood of students who stuttered being bullied, the negative relation of adjustment variables and bullying, and the …
Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation.
Clancy JP, Rowe SM, Accurso FJ, Aitken ML, Amin RS, Ashlock MA, Ballmann M, Boyle MP, Bronsveld I, Campbell PW, De Boeck K, Donaldson SH, Dorkin HL, Dunitz JM, Durie PR, Jain M, Leonard A, McCoy KS, Moss RB, Pilewski JM, Rosenbluth DB, Rubenstein RC, Schechter MS, Botfield M, Ordoñez CL, Spencer-Green GT, Vernillet L, Wisseh S, Yen K, Konstan MW. Clancy JP, et al. Among authors: boyle mp. Thorax. 2012 Jan;67(1):12-8. doi: 10.1136/thoraxjnl-2011-200393. Epub 2011 Aug 8. Thorax. 2012. PMID: 21825083 Free PMC article. Clinical Trial.
Additional data are needed to determine how improvements detected in CFTR function secondary to VX-809 in the sweat gland relate to those measurable in the respiratory tract and to long-term measures of clinical benefit. CLINICAL TRIAL NUMBER: NCT00865904....
Additional data are needed to determine how improvements detected in CFTR function secondary to VX-809 in the sweat gland relate to those me …
Mindfulness training in stuttering therapy: a tutorial for speech-language pathologists.
Boyle MP. Boyle MP. J Fluency Disord. 2011 Jun;36(2):122-9. doi: 10.1016/j.jfludis.2011.04.005. Epub 2011 Apr 23. J Fluency Disord. 2011. PMID: 21664530
In the area of stuttering, it has been widely recognized that effective long-term management often necessitates treatment of cognitive and affective dimensions of the disorder in addition to behavioral components. ...Mindfulness practice results in decreased avoidance, inc …
In the area of stuttering, it has been widely recognized that effective long-term management often necessitates treatment of cognitiv …
Incidence and risk factors for multiple antibiotic-resistant Pseudomonas aeruginosa in cystic fibrosis.
Merlo CA, Boyle MP, Diener-West M, Marshall BC, Goss CH, Lechtzin N. Merlo CA, et al. Among authors: boyle mp. Chest. 2007 Aug;132(2):562-8. doi: 10.1378/chest.06-2888. Epub 2007 Jul 23. Chest. 2007. PMID: 17646236
Independent risk factors for MARPA included CF-related diabetes mellitus (hazard ratio [HR], 1.64; 95% confidence interval [CI], 1.11 to 2.43), long-term inhaled tobramycin usage (HR, 2.08; 95% CI, 1.56 to 2.77), and care at a CF center with a baseline MARPA prevalence in …
Independent risk factors for MARPA included CF-related diabetes mellitus (hazard ratio [HR], 1.64; 95% confidence interval [CI], 1.11 to 2.4 …
Guide to bone health and disease in cystic fibrosis.
Aris RM, Merkel PA, Bachrach LK, Borowitz DS, Boyle MP, Elkin SL, Guise TA, Hardin DS, Haworth CS, Holick MF, Joseph PM, O'Brien K, Tullis E, Watts NB, White TB. Aris RM, et al. Among authors: boyle mp. J Clin Endocrinol Metab. 2005 Mar;90(3):1888-96. doi: 10.1210/jc.2004-1629. Epub 2004 Dec 21. J Clin Endocrinol Metab. 2005. PMID: 15613415 Review.
The life span of these patients has increased from approximately 2 to 32 yr of age over the last three decades. Bone disease has emerged as a common complication in long-term survivors of CF. Some studies have observed that 50-75% of adults have low bone density and increa …
The life span of these patients has increased from approximately 2 to 32 yr of age over the last three decades. Bone disease has emerged as …
Evidence of CFTR function in cystic fibrosis after systemic administration of 4-phenylbutyrate.
Zeitlin PL, Diener-West M, Rubenstein RC, Boyle MP, Lee CK, Brass-Ernst L. Zeitlin PL, et al. Among authors: boyle mp. Mol Ther. 2002 Jul;6(1):119-26. doi: 10.1006/mthe.2002.0639. Mol Ther. 2002. PMID: 12095312 Free article. Clinical Trial.
A maximum tolerated dose of 20 g was defined based on minimal adverse reactions, the safety profile, and a statistically significant induction of chloride transport that was maximal by day 3. This short-term phase I/II study demonstrates proof of principle that modulation …
A maximum tolerated dose of 20 g was defined based on minimal adverse reactions, the safety profile, and a statistically significant inducti …
Unique presentations and chronic complications in adult cystic fibrosis: do they teach us anything about CFTR?
Boyle MP. Boyle MP. Respir Res. 2000;1(3):133-5. doi: 10.1186/rr23. Epub 2000 Nov 16. Respir Res. 2000. PMID: 11667976 Free PMC article. Review.
Current data suggest that the 'chronic complications' reveal mainly the effect of a long-term absence of previously recognized CFTR functions. In contrast, the 'unique presentations' provide new insight into the role of CFTR in different tissues....
Current data suggest that the 'chronic complications' reveal mainly the effect of a long-term absence of previously recognized CFTR f …