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Di-cationic arylimidamides act against Neospora caninum tachyzoites by interference in membrane structure and nucleolar integrity and are active against challenge infection in mice.
Schorer M, Debache K, Barna F, Monney T, Müller J, Boykin DW, Stephens CE, Hemphill A. Schorer M, et al. Among authors: boykin dw. Int J Parasitol Drugs Drug Resist. 2012 Apr 2;2:109-20. doi: 10.1016/j.ijpddr.2012.03.001. eCollection 2012 Dec. Int J Parasitol Drugs Drug Resist. 2012. PMID: 24533272 Free PMC article.
TEM of intracellular tachyzoites identified distinct alterations related to the nucleolus and the nuclear and cellular membrane. Long-term growth assays showed that DB745 acted parasiticidal upon the Nc-Liv isolate, but not against the Nc-1 isolate of N. caninum. ...
TEM of intracellular tachyzoites identified distinct alterations related to the nucleolus and the nuclear and cellular membrane. Long-ter …
A thermodynamic and structural analysis of DNA minor-groove complex formation.
Mazur S, Tanious FA, Ding D, Kumar A, Boykin DW, Simpson IJ, Neidle S, Wilson WD. Mazur S, et al. Among authors: boykin dw. J Mol Biol. 2000 Jul 7;300(2):321-37. doi: 10.1006/jmbi.2000.3869. J Mol Biol. 2000. PMID: 10873468
All three compounds have a major contribution to binding from hydrophobic interactions but the hydrophobic term is most favorable for DB244. DB244 also has strong contributions from molecular interactions in its DNA complex and all of these factors combine to give it the l …
All three compounds have a major contribution to binding from hydrophobic interactions but the hydrophobic term is most favorable for …