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Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients.
Li X, Hawkins GA, Ampleford EJ, Moore WC, Li H, Hastie AT, Howard TD, Boushey HA, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Israel E, Lemanske RF Jr, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Li X, et al. Among authors: boushey ha. J Allergy Clin Immunol. 2013 Aug;132(2):313-20.e15. doi: 10.1016/j.jaci.2013.01.051. Epub 2013 Mar 28. J Allergy Clin Immunol. 2013. PMID: 23541324 Free PMC article.
Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial.
Calhoun WJ, Ameredes BT, King TS, Icitovic N, Bleecker ER, Castro M, Cherniack RM, Chinchilli VM, Craig T, Denlinger L, DiMango EA, Engle LL, Fahy JV, Grant JA, Israel E, Jarjour N, Kazani SD, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Moore WC, Pascual R, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Boushey HA; Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute. Calhoun WJ, et al. Among authors: boushey ha. JAMA. 2012 Sep 12;308(10):987-97. doi: 10.1001/2012.jama.10893. JAMA. 2012. PMID: 22968888 Free PMC article. Clinical Trial.
DESIGN, SETTING, AND PARTICIPANTS: A randomized, parallel, 3-group, placebo-controlled, multiply-blinded trial of 342 adults with mild to moderate asthma controlled by low-dose inhaled corticosteroid therapy (n = 114 assigned to physician assessment-based adjustment [101 complete …
DESIGN, SETTING, AND PARTICIPANTS: A randomized, parallel, 3-group, placebo-controlled, multiply-blinded trial of 342 adults with mild to mo …
Clinical expert panel on monitoring potential lung toxicity of inhaled oligonucleotides: consensus points and recommendations.
Alton EW, Boushey HA, Garn H, Green FH, Hodges M, Martin RJ, Murdoch RD, Renz H, Shrewsbury SB, Seguin R, Johnson G, Parry JD, Tepper J, Renzi P, Cavagnaro J, Ferrari N. Alton EW, et al. Among authors: boushey ha. Nucleic Acid Ther. 2012 Aug;22(4):246-54. doi: 10.1089/nat.2012.0345. Epub 2012 Jul 18. Nucleic Acid Ther. 2012. PMID: 22809313 Free PMC article.
To that end, identification of sensitive methods and biomarkers that can detect toxicity in humans before any long term and/or irreversible side effects occur would be helpful. In light of the public's greater interests, the Inhalation Subcommittee of the Oligonucleotide S …
To that end, identification of sensitive methods and biomarkers that can detect toxicity in humans before any long term and/or irreve …
Influence of lightweight ambulatory oxygen on oxygen use and activity patterns of COPD patients receiving long-term oxygen therapy.
Casaburi R, Porszasz J, Hecht A, Tiep B, Albert RK, Anthonisen NR, Bailey WC, Connett JE, Cooper JA Jr, Criner GJ, Curtis J, Dransfield M, Lazarus SC, Make B, Martinez FJ, McEvoy C, Niewoehner DE, Reilly JJ, Scanlon P, Scharf SM, Sciurba FC, Woodruff P; COPD Clinical Research Network. Casaburi R, et al. COPD. 2012 Feb;9(1):3-11. doi: 10.3109/15412555.2011.630048. COPD. 2012. PMID: 22292592 Clinical Trial.
We studied 22 patients with severe chronic obstructive pulmonary disease receiving long-term oxygen therapy (14 men, average age = 66.9 y, FEV(1) = 33.6%pred, PaO(2) at rest = 51.7 torr) who were using E-cylinders as their portable oxygen. ...
We studied 22 patients with severe chronic obstructive pulmonary disease receiving long-term oxygen therapy (14 men, average age = 66 …
Methodology for using long-term accelerometry monitoring to describe daily activity patterns in COPD.
Hecht A, Ma S, Porszasz J, Casaburi R; COPD Clinical Research Network. Hecht A, et al. COPD. 2009 Apr;6(2):121-9. doi: 10.1080/15412550902755044. COPD. 2009. PMID: 19378225 Free PMC article. Clinical Trial.
We sought to develop procedures for computerized analysis of long-term, high-resolution activity monitoring data that allow accurate assessment of the time course of activity levels suitable for use in chronic obstructive pulmonary disease (COPD) patients. Twenty-two COPD …
We sought to develop procedures for computerized analysis of long-term, high-resolution activity monitoring data that allow accurate …
Individualized asthma self-management improves medication adherence and markers of asthma control.
Janson SL, McGrath KW, Covington JK, Cheng SC, Boushey HA. Janson SL, et al. Among authors: boushey ha. J Allergy Clin Immunol. 2009 Apr;123(4):840-6. doi: 10.1016/j.jaci.2009.01.053. J Allergy Clin Immunol. 2009. PMID: 19348923 Free PMC article. Clinical Trial.
BACKGROUND: Adherence to inhaled anti-inflammatory therapy and self-management skills are essential parts of the asthma treatment plan to improve asthma control and prevent exacerbations. Whether self-management education improves long-term medication adherence is less cle …
BACKGROUND: Adherence to inhaled anti-inflammatory therapy and self-management skills are essential parts of the asthma treatment plan to im …
The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial.
Martin RJ, Szefler SJ, King TS, Kraft M, Boushey HA, Chinchilli VM, Craig TJ, Dimango EA, Deykin A, Fahy JV, Israel E, Lazarus SC, Lemanske RF Jr, Leone FT, Pesola GR, Peters SP, Sorkness CA, Szwejbka LA, Wechsler ME; National Heart, Lung, and Blood Institute's Asthma Clinical Research Center. Martin RJ, et al. Among authors: boushey ha. J Allergy Clin Immunol. 2007 Jan;119(1):73-80. doi: 10.1016/j.jaci.2006.10.035. J Allergy Clin Immunol. 2007. PMID: 17208587 Free PMC article. Clinical Trial.
Dividing the subjects in the short-term inhaled steroid trial into responders (>5% FEV(1) improvement) and nonresponders (<or=5%) determined the longer-term need for steroids. ...CONCLUSION: The short-term response to inhaled corticosteroids with regard …
Dividing the subjects in the short-term inhaled steroid trial into responders (>5% FEV(1) improvement) and nonresponders (<or=5 …
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial.
Israel E, Chinchilli VM, Ford JG, Boushey HA, Cherniack R, Craig TJ, Deykin A, Fagan JK, Fahy JV, Fish J, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF Jr, Liggett SB, Martin RJ, Mitra N, Peters SP, Silverman E, Sorkness CA, Szefler SJ, Wechsler ME, Weiss ST, Drazen JM; National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. Israel E, et al. Among authors: boushey ha. Lancet. 2004 Oct 23-29;364(9444):1505-12. doi: 10.1016/S0140-6736(04)17273-5. Lancet. 2004. PMID: 15500895 Clinical Trial.
INTERPRETATION: Genotype at the 16th aminoacid residue of the beta2-adrenergic receptor affects the long-term response to albuterol use. Bronchodilator treatments avoiding albuterol may be appropriate for patients with the Arg/Arg genotype....
INTERPRETATION: Genotype at the 16th aminoacid residue of the beta2-adrenergic receptor affects the long-term response to albuterol u …
Airway inflammation and remodeling in asthma.
Fahy JV, Corry DB, Boushey HA. Fahy JV, et al. Among authors: boushey ha. Curr Opin Pulm Med. 2000 Jan;6(1):15-20. doi: 10.1097/00063198-200001000-00004. Curr Opin Pulm Med. 2000. PMID: 10608420 Review.
Inflammation in asthma may be the result of a peculiar type of lymphocytic inflammation whereby Th2 lymphocytes secrete cytokines that orchestrate cellular inflammation and promote airway hyperresponsiveness. The term "airway remodeling" in asthma refers to structural chan …
Inflammation in asthma may be the result of a peculiar type of lymphocytic inflammation whereby Th2 lymphocytes secrete cytokines that orche …
Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. Asthma Clinical Research Network.
Drazen JM, Israel E, Boushey HA, Chinchilli VM, Fahy JV, Fish JE, Lazarus SC, Lemanske RF, Martin RJ, Peters SP, Sorkness C, Szefler SJ. Drazen JM, et al. Among authors: boushey ha. N Engl J Med. 1996 Sep 19;335(12):841-7. doi: 10.1056/NEJM199609193351202. N Engl J Med. 1996. PMID: 8778601 Free article. Clinical Trial.
The statistically significant differences between the groups in evening peak flow and in the short-term bronchodilator response to inhaled albuterol were small and judged to be clinically unimportant. ...
The statistically significant differences between the groups in evening peak flow and in the short-term bronchodilator response to in …
13 results