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Effects of Alteplase for Acute Stroke on the Distribution of Functional Outcomes: A Pooled Analysis of 9 Trials.
Lees KR, Emberson J, Blackwell L, Bluhmki E, Davis SM, Donnan GA, Grotta JC, Kaste M, von Kummer R, Lansberg MG, Lindley RI, Lyden P, Murray GD, Sandercock PA, Toni D, Toyoda K, Wardlaw JM, Whiteley WN, Baigent C, Hacke W, Howard G; Stroke Thrombolysis Trialists’ Collaborators Group. Lees KR, et al. Among authors: bluhmki e. Stroke. 2016 Sep;47(9):2373-9. doi: 10.1161/STROKEAHA.116.013644. Epub 2016 Aug 9. Stroke. 2016. PMID: 27507856 Free PMC article. Clinical Trial.
Ordinal logistic regression models assessed treatment differences after adjustment for treatment delay, age, stroke severity, and relevant interaction term(s). RESULTS: Treatment with alteplase was beneficial for a delay in treatment extending to 4.5 hours after stroke ons …
Ordinal logistic regression models assessed treatment differences after adjustment for treatment delay, age, stroke severity, and relevant i …
Stroke Severity and Comorbidity Index for Prediction of Mortality after Ischemic Stroke from the Virtual International Stroke Trials Archive-Acute Collaboration.
Phan TG, Clissold B, Ly J, Ma H, Moran C, Srikanth V; VISTA–Acute Collaboration. Phan TG, et al. J Stroke Cerebrovasc Dis. 2016 Apr;25(4):835-42. doi: 10.1016/j.jstrokecerebrovasdis.2015.12.016. Epub 2016 Jan 18. J Stroke Cerebrovasc Dis. 2016. PMID: 26796056 Free article.
Adding the baseline NIHSS to model 1 improved the NRI by 0.671 (95% confidence interval [CI] 0.595-0.747) [or 67.1% correct reclassification between model 1 and model 2]. Adding the 24 hour NIHSS term to model 1 (model 3) improved the NRI by 0.929 (95% CI 0.857-1.000) for …
Adding the baseline NIHSS to model 1 improved the NRI by 0.671 (95% confidence interval [CI] 0.595-0.747) [or 67.1% correct reclassification …
Design and baseline characteristics of the CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (CAROLINA®).
Marx N, Rosenstock J, Kahn SE, Zinman B, Kastelein JJ, Lachin JM, Espeland MA, Bluhmki E, Mattheus M, Ryckaert B, Patel S, Johansen OE, Woerle HJ. Marx N, et al. Among authors: bluhmki e. Diab Vasc Dis Res. 2015 May;12(3):164-74. doi: 10.1177/1479164115570301. Epub 2015 Mar 15. Diab Vasc Dis Res. 2015. PMID: 25780262 Free PMC article. Clinical Trial.
CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (NCT01243424) is an ongoing, randomized trial in subjects with early type 2 diabetes and increased cardiovascular risk or established complications that will determine the long-term cardiovas …
CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (NCT01243424) is an ongoing, randomized trial in subjects …
Rationale, design, and baseline characteristics of a randomized, placebo-controlled cardiovascular outcome trial of empagliflozin (EMPA-REG OUTCOME™).
Zinman B, Inzucchi SE, Lachin JM, Wanner C, Ferrari R, Fitchett D, Bluhmki E, Hantel S, Kempthorne-Rawson J, Newman J, Johansen OE, Woerle HJ, Broedl UC. Zinman B, et al. Among authors: bluhmki e. Cardiovasc Diabetol. 2014 Jun 19;13:102. doi: 10.1186/1475-2840-13-102. Cardiovasc Diabetol. 2014. PMID: 24943000 Free PMC article. Clinical Trial.
The aim of the ongoing EMPA-REG OUTCOME trial is to determine the long-term CV safety of empagliflozin, as well as investigating potential benefits on macro-/microvascular outcomes. ...
The aim of the ongoing EMPA-REG OUTCOME trial is to determine the long-term CV safety of empagliflozin, as well as investigating pote …
Cardiovascular outcome trials in type 2 diabetes and the sulphonylurea controversy: rationale for the active-comparator CAROLINA trial.
Rosenstock J, Marx N, Kahn SE, Zinman B, Kastelein JJ, Lachin JM, Bluhmki E, Patel S, Johansen OE, Woerle HJ. Rosenstock J, et al. Among authors: bluhmki e. Diab Vasc Dis Res. 2013 Jul;10(4):289-301. doi: 10.1177/1479164112475102. Epub 2013 Feb 28. Diab Vasc Dis Res. 2013. PMID: 23449634 Free article. Review.
Concerns have been raised from observational retrospective studies on the cardiovascular (CV) safety of SUs but there are few long-term data on CV outcomes from randomized controlled trials (RCTs) involving the use of this class of agents. ...To address the SU controversy, …
Concerns have been raised from observational retrospective studies on the cardiovascular (CV) safety of SUs but there are few long-term …
Single-bolus tenecteplase plus heparin compared with heparin alone for normotensive patients with acute pulmonary embolism who have evidence of right ventricular dysfunction and myocardial injury: rationale and design of the Pulmonary Embolism Thrombolysis (PEITHO) trial.
Steering Committee. Steering Committee. Am Heart J. 2012 Jan;163(1):33-38.e1. doi: 10.1016/j.ahj.2011.10.003. Am Heart J. 2012. PMID: 22172434 Clinical Trial.
Thrombolysis rapidly reverses RV pressure overload in PE, but it remains unclear whether it may improve the early and long-term clinical outcome of selected normotensive patients. DESIGN: The Pulmonary EmbolIsm THrOmbolysis (PEITHO) trial is a prospective, multicenter, int …
Thrombolysis rapidly reverses RV pressure overload in PE, but it remains unclear whether it may improve the early and long-term clini …
Sulfonylurea use before stroke does not influence outcome.
Favilla CG, Mullen MT, Ali M, Higgins P, Kasner SE; Virtual International Stroke Trials Archive (VISTA) Collaboration. Favilla CG, et al. Stroke. 2011 Mar;42(3):710-5. doi: 10.1161/STROKEAHA.110.599274. Epub 2011 Feb 17. Stroke. 2011. PMID: 21330623
CONCLUSIONS: Sulfonylurea use before stroke onset did not affect stroke severity or long-term functional outcome compared with other DM treatments. This finding casts doubt on the use of sulfonylureas for prophylactic neuroprotection. ...
CONCLUSIONS: Sulfonylurea use before stroke onset did not affect stroke severity or long-term functional outcome compared with other …
Primary end-point times, functional outcome and adverse event profile after acute ischaemic stroke.
Ali M, Sacco RL, Lees KR; VISTA investigators. Ali M, et al. Int J Stroke. 2009 Dec;4(6):432-42. doi: 10.1111/j.1747-4949.2009.00348.x. Int J Stroke. 2009. PMID: 19930052
CONCLUSIONS: We identified complications, which we deemed not to have occurred as a direct consequence of index stroke, but found that the absence of these events did not beneficially alter outcome at either short-term (30 days) or long-term (90 days) follow-up peri …
CONCLUSIONS: We identified complications, which we deemed not to have occurred as a direct consequence of index stroke, but found that the a …
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