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Cervicovaginal fluid proteomic analysis to identify potential biomarkers for preterm birth.
Parry S, Leite R, Esplin MS, Bukowski R, Zhang H, Varner M, Andrews WW, Saade GR, Ilekis J, Reddy UM, Huang H, Sadovsky Y, Blair IA, Biggio J; Eunice Kennedy Shriver National Institute of Child Health and Human Development Genomic and Proteomic Network for Preterm Birth Research. Parry S, et al. Among authors: blair ia. Am J Obstet Gynecol. 2020 May;222(5):493.e1-493.e13. doi: 10.1016/j.ajog.2019.11.1252. Epub 2019 Nov 20. Am J Obstet Gynecol. 2020. PMID: 31758918 Free PMC article.
A validation study was performed in second-trimester cervicovaginal fluid samples from an independent study group (12 spontaneous preterm birth cases, 19 term delivery controls) using enzyme-linked immunosorbent assay for 5 proteins expressed at higher levels in spo …
A validation study was performed in second-trimester cervicovaginal fluid samples from an independent study group (12 spontaneous preterm …
Impact of route of administration on genotoxic oestrogens concentrations using oral vs transdermal oestradiol in girls with Turner syndrome.
Mauras N, Torres-Santiago L, Santen R, Mericq V, Ross J, Colon-Otero G, Damaso L, Hossain J, Wang Q, Mesaros C, Blair IA. Mauras N, et al. Among authors: blair ia. Clin Endocrinol (Oxf). 2019 Jan;90(1):155-161. doi: 10.1111/cen.13869. Epub 2018 Oct 25. Clin Endocrinol (Oxf). 2019. PMID: 30281805 Clinical Trial.
OBJECTIVE: The established link between oestrogen and breast cancer occurs via both oestrogen receptor (ER)-mediated and non ER-mediated mechanisms. The term genotoxic estrogens describes mutagenic metabolites, including oestrogen catechols and quinones, which have been li …
OBJECTIVE: The established link between oestrogen and breast cancer occurs via both oestrogen receptor (ER)-mediated and non ER-mediated mec …
Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS.
Mazaleuskaya LL, Salamatipour A, Sarantopoulou D, Weng L, FitzGerald GA, Blair IA, Mesaros C. Mazaleuskaya LL, et al. Among authors: blair ia. J Lipid Res. 2018 Mar;59(3):564-575. doi: 10.1194/jlr.D081414. Epub 2018 Jan 4. J Lipid Res. 2018. PMID: 29301865 Free PMC article.
An acute exposure to zymosan induced 80% of the chiral plasma lipids, including 12(S)-HHT, 5(S)-HETE, 15(R)-HETE, and 15(S)-HETE, while a maximum response to LPS was achieved after a long-term stimulation. The reported method allows for a rapid quantification with high sen …
An acute exposure to zymosan induced 80% of the chiral plasma lipids, including 12(S)-HHT, 5(S)-HETE, 15(R)-HETE, and 15(S)-HETE, while a ma …
Testicular vs adrenal sources of hydroxy-androgens in prostate cancer.
Zang T, Taplin ME, Tamae D, Xie W, Mesaros C, Zhang Z, Bubley G, Montgomery B, Balk SP, Mostaghel EA, Blair IA, Penning TM. Zang T, et al. Among authors: blair ia. Endocr Relat Cancer. 2017 Aug;24(8):393-404. doi: 10.1530/ERC-17-0107. Epub 2017 Jun 29. Endocr Relat Cancer. 2017. PMID: 28663228 Free PMC article. Clinical Trial.
Neoadjuvant androgen deprivation therapy (NADT) is one strategy for the treatment of early-stage prostate cancer; however, the long-term outcomes of NADT with radical prostatectomy including biochemical failure-free survival are not promising. ...
Neoadjuvant androgen deprivation therapy (NADT) is one strategy for the treatment of early-stage prostate cancer; however, the long-term …
Second trimester amniotic fluid bisphenol A concentration is associated with decreased birth weight in term infants.
Pinney SE, Mesaros CA, Snyder NW, Busch CM, Xiao R, Aijaz S, Ijaz N, Blair IA, Manson JM. Pinney SE, et al. Among authors: blair ia. Reprod Toxicol. 2017 Jan;67:1-9. doi: 10.1016/j.reprotox.2016.11.007. Epub 2016 Nov 6. Reprod Toxicol. 2017. PMID: 27829162 Free PMC article.
Our aim was to characterize human fetal BPA exposure by measuring BPA concentration in second trimester amniotic fluid (AF) samples and to study its relationship with birth weight (BW) in full term infants. To achieve these goals, we developed a total BPA assay util …
Our aim was to characterize human fetal BPA exposure by measuring BPA concentration in second trimester amniotic fluid (AF) samples and to s …
Estrogens and Their Genotoxic Metabolites Are Increased in Obese Prepubertal Girls.
Mauras N, Santen RJ, Colón-Otero G, Hossain J, Wang Q, Mesaros C, Blair IA. Mauras N, et al. Among authors: blair ia. J Clin Endocrinol Metab. 2015 Jun;100(6):2322-8. doi: 10.1210/jc.2015-1495. Epub 2015 Apr 9. J Clin Endocrinol Metab. 2015. PMID: 25856214 Free PMC article.
These data suggest that obesity is associated with an increased extraglandular estrogen production and metabolism before the onset of puberty in girls. Long-term epidemiological studies are needed to assess any potential increase in breast cancer risk....
These data suggest that obesity is associated with an increased extraglandular estrogen production and metabolism before the onset of pubert …
Maternal serum serpin B7 is associated with early spontaneous preterm birth.
Parry S, Zhang H, Biggio J, Bukowski R, Varner M, Xu Y, Andrews WW, Saade GR, Esplin MS, Leite R, Ilekis J, Reddy UM, Sadovsky Y, Blair IA; Eunice Kennedy Shriver National Institute of Child Health and Human Development Genomic and Proteomic Network for Preterm Birth Research. Parry S, et al. Among authors: blair ia. Am J Obstet Gynecol. 2014 Dec;211(6):678.e1-12. doi: 10.1016/j.ajog.2014.06.035. Epub 2014 Jun 19. Am J Obstet Gynecol. 2014. PMID: 24954659 Free PMC article.
OBJECTIVE: We sought to identify serum biomarkers of early spontaneous preterm birth (SPTB) using semiquantitative proteomic analyses. STUDY DESIGN: This was a nested case-control study of pregnant women with previous SPTB. ...Targeted and shotgun proteomics identified 31 …
OBJECTIVE: We sought to identify serum biomarkers of early spontaneous preterm birth (SPTB) using semiquantitative proteomic analyses …
Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism.
Kinder M, Wei C, Shelat SG, Kundu M, Zhao L, Blair IA, Puré E. Kinder M, et al. Among authors: blair ia. Blood. 2010 Jun 17;115(24):5012-22. doi: 10.1182/blood-2009-09-243139. Epub 2010 Mar 31. Blood. 2010. PMID: 20357242 Free PMC article.
Furthermore, we demonstrate that 12/15-LOX is required for the maintenance of long-term HSC quiescence and number. The defect in HSCs is cell-autonomous and associated with a selective reduction in 12/15-LOX-mediated generation of bioactive lipid mediators and reactive oxy …
Furthermore, we demonstrate that 12/15-LOX is required for the maintenance of long-term HSC quiescence and number. The defect in HSCs …
Folate and homocysteine phenotypes: Comparative findings using research and clinical laboratory data.
Mitchell LE, Morales M, Khartulyari S, Huang Y, Murphy K, Mei M, Von Feldt JM, Blair IA, Whitehead AS. Mitchell LE, et al. Among authors: blair ia. Clin Biochem. 2009 Aug;42(12):1275-81. doi: 10.1016/j.clinbiochem.2009.04.014. Epub 2009 May 8. Clin Biochem. 2009. PMID: 19427846 Free PMC article.
Folate and total homocysteine (tHcy) measurements are used clinically to assess risk and the need for folic acid supplementation and in research to investigate the metabolic basis of disease. Red blood cell (RBC) folate, the best indicator of long-term folate status, is us …
Folate and total homocysteine (tHcy) measurements are used clinically to assess risk and the need for folic acid supplementation and in rese …
Identification and quantification of preterm birth biomarkers in human cervicovaginal fluid by liquid chromatography/tandem mass spectrometry.
Shah SJ, Yu KH, Sangar V, Parry SI, Blair IA. Shah SJ, et al. Among authors: blair ia. J Proteome Res. 2009 May;8(5):2407-17. doi: 10.1021/pr8010342. J Proteome Res. 2009. PMID: 19271751 Free PMC article.
Spontaneous preterm birth (PTB) before 37 completed weeks of gestation resulting from preterm labor (PTL) is a leading contributor of perinatal morbidity and mortality. ...Stable isotope dilution LC-multiple reaction monitoring (MRM/MS) assays were then developed for condu …
Spontaneous preterm birth (PTB) before 37 completed weeks of gestation resulting from preterm labor (PTL) is a leading contributor of …
12 results