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Bioengineered airway epithelial grafts with mucociliary function based on collagen IV- and laminin-containing extracellular matrix scaffolds.
Hamilton NJI, Lee DDH, Gowers KHC, Butler CR, Maughan EF, Jevans B, Orr JC, McCann CJ, Burns AJ, MacNeil S, Birchall MA, O'Callaghan C, Hynds RE, Janes SM. Hamilton NJI, et al. Among authors: birchall ma. Eur Respir J. 2020 Jun 18;55(6):1901200. doi: 10.1183/13993003.01200-2019. Print 2020 Jun. Eur Respir J. 2020. PMID: 32444408 Free PMC article.
Using in vivo chick chorioallantoic membrane (CAM), rabbit airway and immunocompromised mouse models, we showed short-term preservation of the cell layer following transplantation.Our results demonstrate the feasibility of generating HBEC grafts on clinically applicable de …
Using in vivo chick chorioallantoic membrane (CAM), rabbit airway and immunocompromised mouse models, we showed short-term preservati …
Otorhinolaryngology and Diving-Part 1: Otorhinolaryngological Hazards Related to Compressed Gas Scuba Diving: A Review.
Lechner M, Sutton L, Fishman JM, Kaylie DM, Moon RE, Masterson L, Klingmann C, Birchall MA, Lund VJ, Rubin JS. Lechner M, et al. Among authors: birchall ma. JAMA Otolaryngol Head Neck Surg. 2018 Mar 1;144(3):252-258. doi: 10.1001/jamaoto.2017.2617. JAMA Otolaryngol Head Neck Surg. 2018. PMID: 29450472 Review.
Divers frequently seek advice from primary care physicians, diving physicians, and otorhinolaryngologists, not only in the acute setting, but also related to the long-term effects of diving. OBSERVATIONS: The principles underpinning diving-related injuries that may present …
Divers frequently seek advice from primary care physicians, diving physicians, and otorhinolaryngologists, not only in the acute setting, bu …
The Host Immune Response to Tissue-Engineered Organs: Current Problems and Future Directions.
Wiles K, Fishman JM, De Coppi P, Birchall MA. Wiles K, et al. Among authors: birchall ma. Tissue Eng Part B Rev. 2016 Jun;22(3):208-19. doi: 10.1089/ten.TEB.2015.0376. Epub 2016 Jan 29. Tissue Eng Part B Rev. 2016. PMID: 26701069 Review.
As the global health burden of chronic disease increases, end-stage organ failure has become a costly and intractable problem. De novo organ creation is one of the long-term goals of the medical community. One of the promising avenues is that of tissue engineering: the use …
As the global health burden of chronic disease increases, end-stage organ failure has become a costly and intractable problem. De novo organ …
Tissue-Engineered Tracheal Replacement in a Child: A 4-Year Follow-Up Study.
Hamilton NJ, Kanani M, Roebuck DJ, Hewitt RJ, Cetto R, Culme-Seymour EJ, Toll E, Bates AJ, Comerford AP, McLaren CA, Butler CR, Crowley C, McIntyre D, Sebire NJ, Janes SM, O'Callaghan C, Mason C, De Coppi P, Lowdell MW, Elliott MJ, Birchall MA. Hamilton NJ, et al. Among authors: birchall ma. Am J Transplant. 2015 Oct;15(10):2750-7. doi: 10.1111/ajt.13318. Epub 2015 Jun 2. Am J Transplant. 2015. PMID: 26037782 Free PMC article.
Cross-sectional area analysis showed restriction of growth within an area of in-stent stenosis. This report demonstrates the long-term viability of a decellularized tissue-engineered trachea within a child. ...
Cross-sectional area analysis showed restriction of growth within an area of in-stent stenosis. This report demonstrates the long-term …
Airway tissue engineering: an update.
Fishman JM, Wiles K, Lowdell MW, De Coppi P, Elliott MJ, Atala A, Birchall MA. Fishman JM, et al. Among authors: birchall ma. Expert Opin Biol Ther. 2014 Oct;14(10):1477-91. doi: 10.1517/14712598.2014.938631. Epub 2014 Aug 7. Expert Opin Biol Ther. 2014. PMID: 25102044 Review.
INTRODUCTION: Prosthetic materials, autologous tissues, cryopreserved homografts and allogeneic tissues have thus far proven unsuccessful in providing long-term functional solutions to extensive upper airway disease and damage. ...
INTRODUCTION: Prosthetic materials, autologous tissues, cryopreserved homografts and allogeneic tissues have thus far proven unsuccessful in …
Laryngotracheal transplantation: technical modifications and functional outcomes.
Farwell DG, Birchall MA, Macchiarini P, Luu QC, de Mattos AM, Gallay BJ, Perez RV, Grow MP, Ramsamooj R, Salgado MD, Brodie HA, Belafsky PC. Farwell DG, et al. Among authors: birchall ma. Laryngoscope. 2013 Oct;123(10):2502-8. doi: 10.1002/lary.24053. Epub 2013 Mar 11. Laryngoscope. 2013. PMID: 23483551
Our patient was already on immunosuppressive medication from prior kidney-pancreas transplantation, and therefore was not exposed to added long-term risk. We describe the unique technical advances, clinical course, and rehabilitation of this patient and the implications fo …
Our patient was already on immunosuppressive medication from prior kidney-pancreas transplantation, and therefore was not exposed to added l …
Biochemical changes caused by decellularization may compromise mechanical integrity of tracheal scaffolds.
Partington L, Mordan NJ, Mason C, Knowles JC, Kim HW, Lowdell MW, Birchall MA, Wall IB. Partington L, et al. Among authors: birchall ma. Acta Biomater. 2013 Feb;9(2):5251-61. doi: 10.1016/j.actbio.2012.10.004. Epub 2012 Oct 8. Acta Biomater. 2013. PMID: 23059415
Tissue-engineered airways have achieved clinical success, but concerns remain about short-term loss of biomechanical properties, necessitating a stent. This study investigated the effect of chemical-enzymatic decellularization on biochemical properties of trachea important …
Tissue-engineered airways have achieved clinical success, but concerns remain about short-term loss of biomechanical properties, nece …
Optical and molecular techniques to identify tumor margins within the larynx.
Hughes OR, Stone N, Kraft M, Arens C, Birchall MA. Hughes OR, et al. Among authors: birchall ma. Head Neck. 2010 Nov;32(11):1544-53. doi: 10.1002/hed.21321. Head Neck. 2010. PMID: 20091681 Review.
Failure to remove tumor cells from the larynx significantly increases the risk of local recurrence following surgical excision. Healthy tissue must be preserved to optimize long-term vocal and swallowing function. It is essential to accurately distinguish between healthy m …
Failure to remove tumor cells from the larynx significantly increases the risk of local recurrence following surgical excision. Healthy tiss …
Defining phonosurgery: a proposal for classification and nomenclature by the Phonosurgery Committee of the European Laryngological Society (ELS).
Friedrich G, Remacle M, Birchall M, Marie JP, Arens C. Friedrich G, et al. Among authors: birchall m. Eur Arch Otorhinolaryngol. 2007 Oct;264(10):1191-200. doi: 10.1007/s00405-007-0333-x. Epub 2007 Jul 24. Eur Arch Otorhinolaryngol. 2007. PMID: 17647008
The term phonosurgery (PS) refers to any operation designed primarily for the improvement or restoration of voice. ...
The term phonosurgery (PS) refers to any operation designed primarily for the improvement or restoration of voice. ...
Early immunological changes associated with laryngeal transplantation in a major histocompatibility complex-matched pig model.
Barker E, Murison P, Macchiarini P, Jones A, Otto C, Rothkoetter HJ, Haverson K, Bailey M, Birchall M, Stokes C. Barker E, et al. Among authors: birchall m. Clin Exp Immunol. 2006 Dec;146(3):503-8. doi: 10.1111/j.1365-2249.2006.03232.x. Clin Exp Immunol. 2006. PMID: 17100771 Free PMC article.
Therefore, the significance of IRI in exacerbating loss of function or rejection of a laryngeal allograft is open to question. Longer-term studies are required....
Therefore, the significance of IRI in exacerbating loss of function or rejection of a laryngeal allograft is open to question. Longer-ter …
15 results