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The vagus nerve is necessary for the rapid and widespread neuronal activation in the brain following oral administration of psychoactive bacteria.
Bharwani A, West C, Champagne-Jorgensen K, McVey Neufeld KA, Ruberto J, Kunze WA, Bienenstock J, Forsythe P. Bharwani A, et al. Among authors: bienenstock j. Neuropharmacology. 2020 Jun 15;170:108067. doi: 10.1016/j.neuropharm.2020.108067. Epub 2020 Mar 26. Neuropharmacology. 2020. PMID: 32224131
These data identify that specific brain regions respond rapidly to gut microbes via vagal-dependent and independent pathways, and demonstrate that acute versus long-term exposure is associated with differential responses in distinct brain regions....
These data identify that specific brain regions respond rapidly to gut microbes via vagal-dependent and independent pathways, and demonstrat …
Prenatal low-dose penicillin results in long-term sex-specific changes to murine behaviour, immune regulation, and gut microbiota.
Champagne-Jorgensen K, Mian MF, Kay S, Hanani H, Ziv O, McVey Neufeld KA, Koren O, Bienenstock J. Champagne-Jorgensen K, et al. Among authors: bienenstock j. Brain Behav Immun. 2020 Feb;84:154-163. doi: 10.1016/j.bbi.2019.11.020. Epub 2019 Nov 27. Brain Behav Immun. 2020. PMID: 31785396
Growing evidence suggests that environmental disruptors of maternal microbes may have significant detrimental consequences for the developing fetus. Antibiotic exposure during early life can have long-term effects on neurodevelopment in mice and humans. Here we explore whe …
Growing evidence suggests that environmental disruptors of maternal microbes may have significant detrimental consequences for the developin …
Oral selective serotonin reuptake inhibitors activate vagus nerve dependent gut-brain signalling.
McVey Neufeld KA, Bienenstock J, Bharwani A, Champagne-Jorgensen K, Mao Y, West C, Liu Y, Surette MG, Kunze W, Forsythe P. McVey Neufeld KA, et al. Among authors: bienenstock j. Sci Rep. 2019 Oct 3;9(1):14290. doi: 10.1038/s41598-019-50807-8. Sci Rep. 2019. PMID: 31582799 Free PMC article.
The vagus nerve can transmit signals to the brain resulting in a reduction in depressive behavior as evidenced by the long-term beneficial effects of electrical stimulation of the vagus in patients with intractable depression. ...
The vagus nerve can transmit signals to the brain resulting in a reduction in depressive behavior as evidenced by the long-term benef …
Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior.
Leclercq S, Mian FM, Stanisz AM, Bindels LB, Cambier E, Ben-Amram H, Koren O, Forsythe P, Bienenstock J. Leclercq S, et al. Among authors: bienenstock j. Nat Commun. 2017 Apr 4;8:15062. doi: 10.1038/ncomms15062. Nat Commun. 2017. PMID: 28375200 Free PMC article.
There is increasing concern about potential long-term effects of antibiotics on children's health. Epidemiological studies have revealed that early-life antibiotic exposure can increase the risk of developing immune and metabolic diseases, and rodent studies have shown tha …
There is increasing concern about potential long-term effects of antibiotics on children's health. Epidemiological studies have revea …
Moody microbes or fecal phrenology: what do we know about the microbiota-gut-brain axis?
Forsythe P, Kunze W, Bienenstock J. Forsythe P, et al. Among authors: bienenstock j. BMC Med. 2016 Apr 19;14:58. doi: 10.1186/s12916-016-0604-8. BMC Med. 2016. PMID: 27090095 Free PMC article.
INTRODUCTION: The microbiota-gut-brain axis is a term that is commonly used and covers a broad set of functions and interactions between the gut microbiome, endocrine, immune and nervous systems and the brain. ...
INTRODUCTION: The microbiota-gut-brain axis is a term that is commonly used and covers a broad set of functions and interactions betw …
Luminal administration ex vivo of a live Lactobacillus species moderates mouse jejunal motility within minutes.
Wang B, Mao YK, Diorio C, Pasyk M, Wu RY, Bienenstock J, Kunze WA. Wang B, et al. Among authors: bienenstock j. FASEB J. 2010 Oct;24(10):4078-88. doi: 10.1096/fj.09-153841. Epub 2010 Jun 2. FASEB J. 2010. PMID: 20519636
We provide evidence for a rapid, strain-specific, dose-dependent action of a live Lactobacillus on small intestinal motility reflexes that recapitulates the long-term effects of LR ingestion. These observations may be useful as a first step to unraveling the pathways invol …
We provide evidence for a rapid, strain-specific, dose-dependent action of a live Lactobacillus on small intestinal motility reflexes that r …
The alchemy of immune privilege explored from a neuroimmunological perspective.
Arck PC, Gilhar A, Bienenstock J, Paus R. Arck PC, et al. Among authors: bienenstock j. Curr Opin Pharmacol. 2008 Aug;8(4):480-9. doi: 10.1016/j.coph.2008.06.003. Epub 2008 Jul 28. Curr Opin Pharmacol. 2008. PMID: 18603017 Review.
The term 'immune privilege' (IP) generally describes the protection of vital structures, such as the brain, the eye, or the pregnant uterus, from the potentially damaging effects of an inflammatory immune response. ...
The term 'immune privilege' (IP) generally describes the protection of vital structures, such as the brain, the eye, or the pregnant …
Characterization and in vivo distribution of influenza-virus-specific T-lymphocytes in the murine respiratory tract.
McDermott MR, Lukacher AE, Braciale VL, Braciale TJ, Bienenstock J. McDermott MR, et al. Among authors: bienenstock j. Am Rev Respir Dis. 1987 Jan;135(1):245-9. doi: 10.1164/arrd.1987.135.1.245. Am Rev Respir Dis. 1987. PMID: 2432811
Cloned populations of antigen-specific, murine T-lymphocytes, maintained in long-term continuous culture, have been reported to exhibit functional activity upon adoptive transfer. ...
Cloned populations of antigen-specific, murine T-lymphocytes, maintained in long-term continuous culture, have been reported to exhib …
Leukocytes in the intestinal epithelium: an unusual immunological compartment.
Ernst PB, Dean Befus A, Bienenstock J. Ernst PB, et al. Among authors: bienenstock j. Immunol Today. 1985 Feb;6(2):50-5. doi: 10.1016/0167-5699(85)90047-7. Immunol Today. 1985. PMID: 25291393
Some are lymphocytes(2) but because the cells are heterogeneous a more precise term for them would be intraepithelial leukocytes (IEL). They are directly in line with macromolecules in transit across the epithelium(2,3) and increase in number in many enteric inflammatory p …
Some are lymphocytes(2) but because the cells are heterogeneous a more precise term for them would be intraepithelial leukocytes (IEL …