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Pharmacokinetics of sapropterin in patients with phenylketonuria.
Clin Pharmacokinet. 2008;47(12):817-25. doi: 10.2165/0003088-200847120-00006.
Clin Pharmacokinet. 2008.
PMID: 19026037
Clinical Trial.
RESULTS: The best structural model to describe the pharmacokinetics of sapropterin was a two-compartment model with first-order input, first-order elimination and a baseline endogenous BH4 concentration term. Total bodyweight was the only significant covariate identified, …
RESULTS: The best structural model to describe the pharmacokinetics of sapropterin was a two-compartment model with first-order input, first …
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