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The gut microbiota in adults with cystic fibrosis compared to colorectal cancer.
Caley LR, Wood HM, Bottomley D, Fuentes Balaguer A, Wilkinson L, Dyson J, Young C, White H, Benton S, Brearley M, Quirke P, Peckham DG. Caley LR, et al. Among authors: benton s. J Cyst Fibros. 2023 Dec 15:S1569-1993(23)01728-9. doi: 10.1016/j.jcf.2023.12.004. Online ahead of print. J Cyst Fibros. 2023. PMID: 38104000 Free article.
Studies assessing the impact of dietary or other interventions and the longer-term use of CFTR modulators on reducing this potentially pro-oncogenic milieu are needed....
Studies assessing the impact of dietary or other interventions and the longer-term use of CFTR modulators on reducing this potentiall …
CDC Deployments to State, Tribal, Local, and Territorial Health Departments for COVID-19 Emergency Public Health Response - United States, January 21-July 25, 2020.
Dirlikov E, Fechter-Leggett E, Thorne SL, Worrell CM, Smith-Grant JC, Chang J, Oster AM, Bjork A, Young S, Perez AU, Aden T, Anderson M, Farrall S, Jones-Wormley J, Walters KH, LeBlanc TT, Kone RG, Hunter D, Cooley LA, Krishnasamy V, Fuld J, Luna-Pinto C, Williams T, O'Connor A, Nett RJ, Villanueva J, Oussayef NL, Walke HT, Shugart JM, Honein MA, Rose DA; CDC COVID-19 State, Tribal, Local, and Territorial Response Team. Dirlikov E, et al. MMWR Morb Mortal Wkly Rep. 2020 Oct 2;69(39):1398-1403. doi: 10.15585/mmwr.mm6939a3. MMWR Morb Mortal Wkly Rep. 2020. PMID: 33001876 Free PMC article.
Deployed teams assisted with the investigation of transmission in high-risk congregate settings, such as long-term care facilities (53 deployments; 26% of total), food processing facilities (24; 12%), correctional facilities (12; 6%), and settings that provide services to …
Deployed teams assisted with the investigation of transmission in high-risk congregate settings, such as long-term care facilities (5 …
Fibrinogen-Like Protein 2-Associated Transcriptional and Histopathological Features of Immunological Preeclampsia.
Robineau-Charette P, Grynspan D, Benton SJ, Gaudet J, Cox BJ, Vanderhyden BC, Bainbridge SA. Robineau-Charette P, et al. Among authors: benton sj. Hypertension. 2020 Sep;76(3):910-921. doi: 10.1161/HYPERTENSIONAHA.120.14807. Epub 2020 Jul 27. Hypertension. 2020. PMID: 32713274 Free PMC article.
This work, overall, demonstrates that FGL-2 expression levels in the term placenta reflect the unique pathophysiology that leads to immunological preeclampsia, leading to its potential as a subtype-specific biomarker....
This work, overall, demonstrates that FGL-2 expression levels in the term placenta reflect the unique pathophysiology that leads to i …
Age, Not Sex, Modifies the Effect of Frailty on Long-term Outcomes After Cardiac Surgery.
Sun LY, Spence SD, Benton S, Beanlands RS, Austin PC, Bader Eddeen A, Lee DS. Sun LY, et al. Among authors: benton s. Ann Surg. 2022 Apr 1;275(4):800-806. doi: 10.1097/SLA.0000000000004060. Ann Surg. 2022. PMID: 32541219
OBJECTIVE: To examine the prevalence of frailty in surgical patients and determine whether age and sex modify the relationship between frailty and long-term mortality. BACKGROUND: Frailty is a complex and prevalent clinical syndrome. ...CONCLUSIONS: We observed a high prev …
OBJECTIVE: To examine the prevalence of frailty in surgical patients and determine whether age and sex modify the relationship between frail …
Placental transcriptional and histologic subtypes of normotensive fetal growth restriction are comparable to preeclampsia.
Gibbs I, Leavey K, Benton SJ, Grynspan D, Bainbridge SA, Cox BJ. Gibbs I, et al. Among authors: benton sj. Am J Obstet Gynecol. 2019 Jan;220(1):110.e1-110.e21. doi: 10.1016/j.ajog.2018.10.003. Epub 2018 Oct 9. Am J Obstet Gynecol. 2019. PMID: 30312585
Additionally, even among fetal growth-restricted pregnancies with evident placental disease, considerable heterogeneity in clinical outcomes and long-term consequences has been observed. Gene expression studies of fetal growth-restricted placentas also have limited consist …
Additionally, even among fetal growth-restricted pregnancies with evident placental disease, considerable heterogeneity in clinical outcomes …
Activated protein C as disease-modifying therapy in antenatal preeclampsia: An open-label, single arm safety and efficacy trial.
von Dadelszen P, Magee LA, Benton SJ, Hu Y, Ansermino JM, Carleton B, Carter C, Douglas MJ, Janssen PA, Lee SK, Leung PCK, Li J, MacNab Y, Payne BA, Peng G, Rodger M, Skoll MA, Synnes A, Walley KR, Russell JA. von Dadelszen P, et al. Among authors: benton sj. Pregnancy Hypertens. 2018 Jul;13:121-126. doi: 10.1016/j.preghy.2018.05.009. Epub 2018 May 28. Pregnancy Hypertens. 2018. PMID: 30177038 Free article. Clinical Trial.
Recombinant human activated protein C (rhAPC; drotrecogin alfa [activated]) may modify disease progression to safely prolong pregnancies and improve perinatal outcomes. Both maternal and perinatal risks are highest remote from term. STUDY DESIGN: Open-label, single arm saf …
Recombinant human activated protein C (rhAPC; drotrecogin alfa [activated]) may modify disease progression to safely prolong pregnancies and …
Unsupervised Placental Gene Expression Profiling Identifies Clinically Relevant Subclasses of Human Preeclampsia.
Leavey K, Benton SJ, Grynspan D, Kingdom JC, Bainbridge SA, Cox BJ. Leavey K, et al. Among authors: benton sj. Hypertension. 2016 Jul;68(1):137-47. doi: 10.1161/HYPERTENSIONAHA.116.07293. Epub 2016 May 9. Hypertension. 2016. PMID: 27160201
Applying unsupervised clustering to this combined data set identified 3 clinically significant probable etiologies of PE: "maternal", with healthy placentas and term deliveries; "canonical", exhibiting expected clinical, ontological, and histopathologic features of PE; and …
Applying unsupervised clustering to this combined data set identified 3 clinically significant probable etiologies of PE: "maternal", with h …
Clozapine for Drug-Refractory Irritability in Individuals with Developmental Disability.
Wink LK, Badran I, Pedapati EV, Sorensen R, Benton SC, Johnson MC, Wissel G, Erickson CA. Wink LK, et al. Among authors: benton sc. J Child Adolesc Psychopharmacol. 2016 Nov;26(9):843-846. doi: 10.1089/cap.2015.0216. Epub 2016 Mar 17. J Child Adolesc Psychopharmacol. 2016. PMID: 26986554
CONCLUSION: These initial results support the potential utility of clozapine rapid titration for treatment of severe refractory irritability in youth with developmental disability. These patients tolerated clozapine treatment in the short term. Future studies are needed to …
CONCLUSION: These initial results support the potential utility of clozapine rapid titration for treatment of severe refractory irritability …
PIERS proteinuria: relationship with adverse maternal and perinatal outcome.
Payne B, Magee LA, Côté AM, Hutcheon JA, Li J, Kyle PM, Menzies JM, Peter Moore M, Parker C, Pullar B, von Dadelszen P, Walters BN; PIERS Study Group (Appendix); von Dadelszen P, Magee LA, Douglas MJ, Walley KR, Russell JA, Lee SK, Gruslin A, Smith GN, Côté AM, Moutquin JM, Brown MA, Davis G, Walters BN, Sass N, Duan T, Zhou J, Mahajan S, Noovao A, McCowan LA, Kyle P, Moore MP, Bhutta SZ, Bhutta ZA, Hall, Steyn DW, Broughton Pipkin F, Loughna P, Robson S, de Swiet M, Walker JJ, Grobman WA, Lindheimer MD, Roberts JM, Mark Ansermino J, Benton S, Cundiff G, Hugo D, Joseph KS, Lalji S, Li J, Lott P, Ouellet AB, Shaw D, Keith Still D, Tawagi G, Wagner B, Biryabarema C, Mirembe F, Nakimuli A, Tsigas E, Merialdi M, Widmer M. Payne B, et al. Among authors: benton s. J Obstet Gynaecol Can. 2011 Jun;33(6):588-597. doi: 10.1016/S1701-2163(16)34907-6. J Obstet Gynaecol Can. 2011. PMID: 21846448
METHODS: We performed a prospective multicentre cohort study, PIERS (Preeclampsia Integrated Estimate of RiSk), in seven academic tertiary maternity centres practising expectant management of preeclampsia remote from term in Canada, New Zealand, and Australia. Eligible wom …
METHODS: We performed a prospective multicentre cohort study, PIERS (Preeclampsia Integrated Estimate of RiSk), in seven academic tertiary m …
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