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Mucus clearance and lung function in cystic fibrosis with hypertonic saline.
Donaldson SH, Bennett WD, Zeman KL, Knowles MR, Tarran R, Boucher RC. Donaldson SH, et al. Among authors: bennett wd. N Engl J Med. 2006 Jan 19;354(3):241-50. doi: 10.1056/NEJMoa043891. N Engl J Med. 2006. PMID: 16421365 Free article. Clinical Trial.
Mucus clearance and lung function were measured during 14-day baseline and treatment periods. RESULTS: Long-term inhalation of hypertonic saline without pretreatment with amiloride (i.e., with placebo pretreatment) resulted in a sustained (> or =8 hours) increase in 1-h …
Mucus clearance and lung function were measured during 14-day baseline and treatment periods. RESULTS: Long-term inhalation of hypert …
Retention and intracellular distribution of instilled iron oxide particles in human alveolar macrophages.
Lay JC, Bennett WD, Kim CS, Devlin RB, Bromberg PA. Lay JC, et al. Among authors: bennett wd. Am J Respir Cell Mol Biol. 1998 May;18(5):687-95. doi: 10.1165/ajrcmb.18.5.2948. Am J Respir Cell Mol Biol. 1998. PMID: 9569239
Particles were cleared from the lavagable AM compartment in a biphasic pattern, with a rapid-phase clearance half-time of 0.5 d and long-term clearance half-time of 110 d, comparable to retention kinetics determined by more traditional methods. ...
Particles were cleared from the lavagable AM compartment in a biphasic pattern, with a rapid-phase clearance half-time of 0.5 d and long- …
Pharmacologic treatment of abnormal ion transport in the airway epithelium in cystic fibrosis.
Knowles MR, Olivier KN, Hohneker KW, Robinson J, Bennett WD, Boucher RC. Knowles MR, et al. Among authors: bennett wd. Chest. 1995 Feb;107(2 Suppl):71S-76S. doi: 10.1378/chest.107.2_supplement.71s. Chest. 1995. PMID: 7842817 Review.
Clinical trials of amiloride are currently underway in adults and adolescents, and short-term safety studies have been initiated in children. Aerosolized uridine triphosphate (UTP) induces Cl- (and liquid) secretion in CF airway epithelia via non-CFTR Cl- channels. Short- …
Clinical trials of amiloride are currently underway in adults and adolescents, and short-term safety studies have been initiated in c …