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Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study.
Chanchlani N, Lin S, Bewshea C, Hamilton B, Thomas A, Smith R, Roberts C, Bishara M, Nice R, Lees CW, Sebastian S, Irving PM, Russell RK, McDonald TJ, Goodhand JR, Ahmad T, Kennedy NA; PANTS Consortium. Chanchlani N, et al. Lancet Gastroenterol Hepatol. 2024 Apr 16:S2468-1253(24)00044-X. doi: 10.1016/S2468-1253(24)00044-X. Online ahead of print. Lancet Gastroenterol Hepatol. 2024. PMID: 38640937
Low drug concentrations at the end of the induction period predict loss of response by year 3 of treatment, suggesting higher drug concentrations during the first year of treatment, particularly during induction, might lead to better long-term outcomes. Anti-drug antibodie …
Low drug concentrations at the end of the induction period predict loss of response by year 3 of treatment, suggesting higher drug concentra …
Pregnancy outcomes for women with pre-existing renal disease and the role of a dedicated joint maternal medicine and renal clinic: A retrospective cohort study.
Wildridge B, Makanjuola D, Johnson A, Ganapathy R, Mountford L, Bell C, Odogwu J, Shehata H. Wildridge B, et al. Among authors: bell c. Int J Gynaecol Obstet. 2024 Mar 22. doi: 10.1002/ijgo.15492. Online ahead of print. Int J Gynaecol Obstet. 2024. PMID: 38520087
The data analyzed included pre-existing renal conditions, biochemical parameters related to the renal condition, pregnancy outcomes included miscarriages, gestation, mode of delivery, postpartum hemorrhage (PPH), loss, birth weight and neonatal admission. RESULTS: The resu …
The data analyzed included pre-existing renal conditions, biochemical parameters related to the renal condition, pregnancy outcomes included …
Long-term kidney outcomes in pediatric continuous-flow ventricular assist device patients.
Idrovo A, Hollander SA, Neumayr TM, Bell C, Munoz G, Choudhry S, Price J, Adachi I, Srivaths P, Sutherland S, Akcan-Arikan A. Idrovo A, et al. Among authors: bell c. Pediatr Nephrol. 2024 Apr;39(4):1289-1300. doi: 10.1007/s00467-023-06190-8. Epub 2023 Nov 16. Pediatr Nephrol. 2024. PMID: 37971519
Post-implantation recovery after acute kidney injury (AKI) is commonly reported, but long-term kidney outcomes or factors implicated in the evolution of chronic kidney disease (CKD) with prolonged CF-VAD support are unknown. ...CONCLUSIONS: In the first multicenter study t …
Post-implantation recovery after acute kidney injury (AKI) is commonly reported, but long-term kidney outcomes or factors implicated …
CO-Creation and Evaluation of Food Environments to Advance Community Health (COACH).
Whelan J, Brimblecombe J, Christian M, Vargas C, Ferguson M, McMahon E, Lee A, Bell C, Boelsen-Robinson T, Blake MR, Lewis M, Alston L, Allender S. Whelan J, et al. Among authors: bell c. AJPM Focus. 2023 May 27;2(3):100111. doi: 10.1016/j.focus.2023.100111. eCollection 2023 Sep. AJPM Focus. 2023. PMID: 37790671 Free PMC article.
These 3 stages were (1) evidence review, including systematic review, consultation with experts, and observation of current work; (2) codesign of the framework prototype with multiple stakeholders; and (3) coproduction through refinement of the prototype through stakeholder works …
These 3 stages were (1) evidence review, including systematic review, consultation with experts, and observation of current work; (2) codesi …
CRISPR/dCas9 DNA methylation editing is heritable during human hematopoiesis and shapes immune progeny.
Saunderson EA, Encabo HH, Devis J, Rouault-Pierre K, Piganeau M, Bell CG, Gribben JG, Bonnet D, Ficz G. Saunderson EA, et al. Among authors: bell cg. Proc Natl Acad Sci U S A. 2023 Aug 22;120(34):e2300224120. doi: 10.1073/pnas.2300224120. Epub 2023 Aug 14. Proc Natl Acad Sci U S A. 2023. PMID: 37579157 Free PMC article.
In vivo, edited human HSPCs can engraft the bone marrow of mice and targeted DNAm is maintained in HSPCs long term. Moreover, epigenetic changes are conserved and inherited in both myeloid and lymphoid lineages. ...
In vivo, edited human HSPCs can engraft the bone marrow of mice and targeted DNAm is maintained in HSPCs long term. Moreover, epigene …
New and Persistent Sedative Prescriptions Among Older Adults Following a Critical Illness: A Population-Based Cohort Study.
Burry LD, Bell CM, Hill A, Pinto R, Scales DC, Bronskill SE, Williamson D, Rose L, Fu L, Fowler R, Martin CM, Dolovich L, Wunsch H. Burry LD, et al. Among authors: bell cm. Chest. 2023 Jun;163(6):1425-1436. doi: 10.1016/j.chest.2022.12.033. Epub 2023 Jan 4. Chest. 2023. PMID: 36610663
Adjusted factors associated with a new sedative included: discharge to long-term care facility (adjusted OR [aOR], 4.00; 95% CI, 3.72-4.31), receipt of inpatient geriatric (aOR, 1.95; 95% CI, 1.80-2.10) or psychiatry (aOR, 2.76; 95% CI, 2.62-2.91) consultation, invasive ve …
Adjusted factors associated with a new sedative included: discharge to long-term care facility (adjusted OR [aOR], 4.00; 95% CI, 3.72 …
The long-term impacts of the Canterbury earthquakes on the mental health of the Christchurch Health and Development Study cohort.
Beaglehole B, Boden JM, Bell C, Mulder RT, Dhakal B, Horwood LJ. Beaglehole B, et al. Among authors: bell c. Aust N Z J Psychiatry. 2023 Jul;57(7):966-974. doi: 10.1177/00048674221138499. Epub 2022 Nov 29. Aust N Z J Psychiatry. 2023. PMID: 36448198
OBJECTIVE: Long-term studies following disasters are rare. It is important to quantify long-term effects of disasters to determine impacts on populations over time. ...METHODS: The Christchurch Health and Development Study is a 40-year longitudinal study of a bir …
OBJECTIVE: Long-term studies following disasters are rare. It is important to quantify long-term effects of disasters to deter …
Evaluating the Use of Glucocorticoids Among Belimumab-Treated Patients With Systemic Lupus Erythematosus in Real-World Settings Using the Rheumatology Informatics System for Effectiveness Registry.
Hammam N, Evans M, Bell CF, Gairy K, Yazdany J, Schmajuk G. Hammam N, et al. Among authors: bell cf. ACR Open Rheumatol. 2022 Oct;4(10):883-889. doi: 10.1002/acr2.11482. Epub 2022 Jul 24. ACR Open Rheumatol. 2022. PMID: 35872599 Free PMC article.
OBJECTIVE: Glucocorticoids are part of standard therapy for systemic lupus erythematosus (SLE), despite adverse effects associated with long-term treatment. Belimumab improved clinical manifestations of SLE and reduced glucocorticoid doses in clinical trials and clinical p …
OBJECTIVE: Glucocorticoids are part of standard therapy for systemic lupus erythematosus (SLE), despite adverse effects associated with long …
Economic Evaluation of Using Daily Prednisolone versus Placebo at the Time of an Upper Respiratory Tract Infection for the Management of Children with Steroid-Sensitive Nephrotic Syndrome: A Model-Based Analysis.
Afentou N, Frew E, Mehta S, Ives NJ, Woolley RL, Brettell EA, Khan AR, Milford DV, Bockenhauer D, Saleem MA, Hall AS, Koziell A, Maxwell H, Hegde S, Finlay E, Gilbert RD, Jones C, McKeever K, Cook W, Webb NJA, Christian MT; PREDNOS Collaborative Group, NIHR Medicines for Children Research Network Nephrology Clinical Studies Group. Afentou N, et al. Pharmacoecon Open. 2022 Jul;6(4):605-617. doi: 10.1007/s41669-022-00334-6. Epub 2022 Jun 22. Pharmacoecon Open. 2022. PMID: 35733076 Free PMC article.
BACKGROUND: Childhood steroid-sensitive nephrotic syndrome is a frequently relapsing disease with significant short- and long-term complications, leading to high healthcare costs and reduced quality of life for patients. ...RESULTS: The base-case results showed that admini …
BACKGROUND: Childhood steroid-sensitive nephrotic syndrome is a frequently relapsing disease with significant short- and long-term co …
Examining the long-term cognitive effects of exposure to the Canterbury earthquakes in a resilient cohort.
Bell C, Moot W, Porter R, Frampton C, Mcintosh V, Purnell M, Smith R, Douglas K. Bell C, et al. BJPsych Open. 2022 Jun 15;8(4):e114. doi: 10.1192/bjo.2022.512. BJPsych Open. 2022. PMID: 35703099 Free PMC article.
We previously reported that 2-3 years after the Canterbury earthquake sequence, a group of trauma-exposed people, who identified as resilient, performed less well on tests of spatial memory, had increased accuracy identifying facial emotions and misclassified neutral facial expre …
We previously reported that 2-3 years after the Canterbury earthquake sequence, a group of trauma-exposed people, who identified as resilien …
202 results