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Advanced Glycation End Products Predict Loss of Renal Function and High-Risk Chronic Kidney Disease in Type 2 Diabetes.
Koska J, Gerstein HC, Beisswenger PJ, Reaven PD. Koska J, et al. Among authors: beisswenger pj. Diabetes Care. 2022 Mar 1;45(3):684-691. doi: 10.2337/dc21-2196. Diabetes Care. 2022. PMID: 35051276 Free PMC article. Clinical Trial.
CONCLUSIONS: These data provide further support for a causal role of AGEs in diabetic nephropathy independently of glycemic control and suggest utility of the composite AGE panel in predicting long-term decline in renal function....
CONCLUSIONS: These data provide further support for a causal role of AGEs in diabetic nephropathy independently of glycemic control and sugg …
Divergent Changes in Plasma AGEs and sRAGE Isoforms Following an Overnight Fast in T1DM.
Miranda ER, Fuller KNZ, Perkins RK, Beisswenger PJ, Farabi SS, Quinn L, Haus JM. Miranda ER, et al. Among authors: beisswenger pj. Nutrients. 2019 Feb 13;11(2):386. doi: 10.3390/nu11020386. Nutrients. 2019. PMID: 30781793 Free PMC article.
Multiple regression analyses revealed a 1 pg/mL increase in total sRAGE, cRAGE, or esRAGE independently predicted a 0.42-0.52 nmol/L decrease in MG-H1. Short-term energy restriction via an overnight fast resulted in increased sRAGE isoforms and may be protective against AG …
Multiple regression analyses revealed a 1 pg/mL increase in total sRAGE, cRAGE, or esRAGE independently predicted a 0.42-0.52 nmol/L decreas …
Advanced Glycation End Products, Oxidation Products, and the Extent of Atherosclerosis During the VA Diabetes Trial and Follow-up Study.
Saremi A, Howell S, Schwenke DC, Bahn G, Beisswenger PJ, Reaven PD; VADT Investigators. Saremi A, et al. Among authors: beisswenger pj. Diabetes Care. 2017 Apr;40(4):591-598. doi: 10.2337/dc16-1875. Epub 2017 Feb 1. Diabetes Care. 2017. PMID: 28148544 Free PMC article.
CONCLUSIONS: Specific advanced glycation end products and metabolic oxidation products are associated with the severity of subclinical atherosclerosis over the long term and may play an important role in the "negative metabolic memory" of macrovascular complications in peo …
CONCLUSIONS: Specific advanced glycation end products and metabolic oxidation products are associated with the severity of subclinical ather …
Effects on post-prandial glucose and AGE precursors from two initial insulin strategies in patients with type 2 diabetes uncontrolled by oral agents.
Sakharova OV, Lleva RR, Dziura JD, Spollett GR, Howell SK, Beisswenger PJ, Inzucchi SE. Sakharova OV, et al. Among authors: beisswenger pj. J Diabetes Complications. 2012 Jul-Aug;26(4):333-8. doi: 10.1016/j.jdiacomp.2012.03.027. Epub 2012 Apr 26. J Diabetes Complications. 2012. PMID: 22541894 Clinical Trial.
CONCLUSION: In type 2 diabetes patients failing OAD therapy, an initial insulin regimen of twice daily premixed insulin results in significantly improved post-prandial glucose levels as well as a reduction in a precursor of AGEs. The effect of these two initial insulin regimens o …
CONCLUSION: In type 2 diabetes patients failing OAD therapy, an initial insulin regimen of twice daily premixed insulin results in significa …
Glycation and biomarkers of vascular complications of diabetes.
Beisswenger PJ. Beisswenger PJ. Amino Acids. 2012 Apr;42(4):1171-83. doi: 10.1007/s00726-010-0784-z. Epub 2010 Nov 2. Amino Acids. 2012. PMID: 21042818 Review.
This review proposes the study of advanced glycation end products (AGEs) and oxidation end-products (OPs) in long-term diabetes outcome studies. AGEs integrate the activity of glycation pathways that form dicarbonyls, while OPs reflect superoxides, hydroxyl radicals, and p …
This review proposes the study of advanced glycation end products (AGEs) and oxidation end-products (OPs) in long-term diabetes outco …
Transglycation--a potential new mechanism for deglycation of Schiff's bases.
Szwergold BS, Howell SK, Beisswenger PJ. Szwergold BS, et al. Among authors: beisswenger pj. Ann N Y Acad Sci. 2005 Jun;1043:845-64. doi: 10.1196/annals.1333.097. Ann N Y Acad Sci. 2005. PMID: 16037312
We postulate that the first step in this Schiff's-base deglycation process occurs by transfer of the sugar moiety from macromolecule-bound glucosylamine to one of the low-molecular weight intracellular nucleophiles-in particular, glutathione. We term this reaction transgly …
We postulate that the first step in this Schiff's-base deglycation process occurs by transfer of the sugar moiety from macromolecule-bound g …
Alpha-oxoaldehyde metabolism and diabetic complications.
Beisswenger PJ, Howell SK, Nelson RG, Mauer M, Szwergold BS. Beisswenger PJ, et al. Biochem Soc Trans. 2003 Dec;31(Pt 6):1358-63. doi: 10.1042/bst0311358. Biochem Soc Trans. 2003. PMID: 14641063 Review.
New therapeutic interventions designed to control these endogenous mechanisms could potentially enhance protection against excessive glycation and prevent or reverse complications of long-term diabetes....
New therapeutic interventions designed to control these endogenous mechanisms could potentially enhance protection against excessive glycati …
Glycated proteins in diabetes.
Beisswenger PJ, Szwergold BS, Yeo KT. Beisswenger PJ, et al. Clin Lab Med. 2001 Mar;21(1):53-78, vi. Clin Lab Med. 2001. PMID: 11321937 Review.
The term nonenzymatic glycation (of protein) refers to a wide variety of spontaneous reactions between reducing sugars and protein-bound amines. ...
The term nonenzymatic glycation (of protein) refers to a wide variety of spontaneous reactions between reducing sugars and protein-bo …
Relationship between glycemic control and collagen-linked advanced glycosylation end products in type I diabetes.
Beisswenger PJ, Moore LL, Curphey TJ. Beisswenger PJ, et al. Diabetes Care. 1993 May;16(5):689-94. doi: 10.2337/diacare.16.5.689. Diabetes Care. 1993. PMID: 8495605
Tissue glycosylation and AGEs are felt to play an important role in the development of these sequelae, but no data are available on the relationship between AGEs and long-term glycemic control. RESEARCH DESIGN AND METHODS: We studied 48 subjects with type I diabetes. ...
Tissue glycosylation and AGEs are felt to play an important role in the development of these sequelae, but no data are available on the rela …