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Disulfiram Treatment Normalizes Body Weight in Obese Mice.
Bernier M, Mitchell SJ, Wahl D, Diaz A, Singh A, Seo W, Wang M, Ali A, Kaiser T, Price NL, Aon MA, Kim EY, Petr MA, Cai H, Warren A, Di Germanio C, Di Francesco A, Fishbein K, Guiterrez V, Harney D, Koay YC, Mach J, Enamorado IN, Pulpitel T, Wang Y, Zhang J, Zhang L, Spencer RG, Becker KG, Egan JM, Lakatta EG, O'Sullivan J, Larance M, LeCouteur DG, Cogger VC, Gao B, Fernandez-Hernando C, Cuervo AM, de Cabo R. Bernier M, et al. Among authors: becker kg. Cell Metab. 2020 Aug 4;32(2):203-214.e4. doi: 10.1016/j.cmet.2020.04.019. Epub 2020 May 14. Cell Metab. 2020. PMID: 32413333 Free PMC article.
Reductions in feeding efficiency and increases in energy expenditure were associated with body weight regulation in response to long-term disulfiram treatment. Loss of fat tissue and an increase in liver fenestrations were also observed in rats on disulfiram. ...
Reductions in feeding efficiency and increases in energy expenditure were associated with body weight regulation in response to long-term …
Survey of the Arc Epigenetic Landscape in Normal Cognitive Aging.
Myrum C, Kittleson J, De S, Fletcher BR, Castellano J, Kundu G, Becker KG, Rapp PR. Myrum C, et al. Among authors: becker kg. Mol Neurobiol. 2020 Jun;57(6):2727-2740. doi: 10.1007/s12035-020-01915-4. Epub 2020 Apr 24. Mol Neurobiol. 2020. PMID: 32333254 Free PMC article.
Aging is accompanied by aberrant gene expression that ultimately affects brain plasticity and the capacity to form long-term memories. Immediate-early genes (IEGs) play an active role in these processes. ...
Aging is accompanied by aberrant gene expression that ultimately affects brain plasticity and the capacity to form long-term memories …
Absence of cannabinoid 1 receptor in beta cells protects against high-fat/high-sugar diet-induced beta cell dysfunction and inflammation in murine islets.
González-Mariscal I, Montoro RA, Doyle ME, Liu QR, Rouse M, O'Connell JF, Santa-Cruz Calvo S, Krzysik-Walker SM, Ghosh S, Carlson OD, Lehrmann E, Zhang Y, Becker KG, Chia CW, Ghosh P, Egan JM. González-Mariscal I, et al. Among authors: becker kg. Diabetologia. 2018 Jun;61(6):1470-1483. doi: 10.1007/s00125-018-4576-4. Epub 2018 Mar 1. Diabetologia. 2018. PMID: 29497784 Free PMC article.
METHODS: We generated a beta cell specific Cnr1 (CB1R) knockout mouse (beta-CB1R(-/-)) to study the long-term consequences of CB1R ablation on beta cell function in adult mice. ...
METHODS: We generated a beta cell specific Cnr1 (CB1R) knockout mouse (beta-CB1R(-/-)) to study the long-term consequences of CB1R ab …
Mild traumatic brain injury-induced hippocampal gene expressions: The identification of target cellular processes for drug development.
Tweedie D, Rachmany L, Kim DS, Rubovitch V, Lehrmann E, Zhang Y, Becker KG, Perez E, Pick CG, Greig NH. Tweedie D, et al. Among authors: becker kg. J Neurosci Methods. 2016 Oct 15;272:4-18. doi: 10.1016/j.jneumeth.2016.02.003. Epub 2016 Feb 8. J Neurosci Methods. 2016. PMID: 26868732 Free PMC article.
BACKGROUND: Neurological dysfunction after traumatic brain injury (TBI) poses short-term or long-lasting health issues for family members and health care providers. ...
BACKGROUND: Neurological dysfunction after traumatic brain injury (TBI) poses short-term or long-lasting health issues for family mem …
Platelet MicroRNAs: An Overview.
Dahiya N, Sarachana T, Vu L, Becker KG, Wood WH 3rd, Zhang Y, Atreya CD. Dahiya N, et al. Among authors: becker kg. Transfus Med Rev. 2015 Oct;29(4):215-9. doi: 10.1016/j.tmrv.2015.08.002. Epub 2015 Aug 10. Transfus Med Rev. 2015. PMID: 26341586 Free PMC article. Review.
Target prediction studies are, nonetheless, valuable in directing the design of appropriate experiments to test specific miRNA:messenger RNA interactions relevant to the underlying mechanisms of platelet function in general and in disease as well as in ex vivo storage-associated …
Target prediction studies are, nonetheless, valuable in directing the design of appropriate experiments to test specific miRNA:messenger RNA …
Postnatal TLR2 activation impairs learning and memory in adulthood.
Madar R, Rotter A, Waldman Ben-Asher H, Mughal MR, Arumugam TV, Wood WH 3rd, Becker KG, Mattson MP, Okun E. Madar R, et al. Among authors: becker kg. Brain Behav Immun. 2015 Aug;48:301-12. doi: 10.1016/j.bbi.2015.04.020. Epub 2015 May 27. Brain Behav Immun. 2015. PMID: 26021559 Free PMC article.
Postnatal infections can also induce neuroinflammatory responses with long-term consequences. These inflammatory responses can lead to motor deficits and/or behavioral disabilities. ...These results imply that adult cognitive behavior could be influenced in part, by activa …
Postnatal infections can also induce neuroinflammatory responses with long-term consequences. These inflammatory responses can lead t …
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.
Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, González-Reyes JA, Villalba JM, Baur JA, Elliott P, Westphal C, Vlasuk GP, Ellis JL, Sinclair DA, Bernier M, de Cabo R. Mercken EM, et al. Among authors: becker kg. Aging Cell. 2014 Oct;13(5):787-96. doi: 10.1111/acel.12220. Epub 2014 Jun 16. Aging Cell. 2014. PMID: 24931715 Free PMC article.
This is accompanied by improvements in health, including enhanced motor coordination, performance, bone mineral density, and insulin sensitivity associated with higher mitochondrial content and decreased inflammation. Short-term SRT2104 treatment preserves bone and muscle …
This is accompanied by improvements in health, including enhanced motor coordination, performance, bone mineral density, and insulin sensiti …
Enhanced upregulation of CRH mRNA expression in the nucleus accumbens of male rats after a second injection of methamphetamine given thirty days later.
Cadet JL, Brannock C, Ladenheim B, McCoy MT, Krasnova IN, Lehrmann E, Becker KG, Jayanthi S. Cadet JL, et al. Among authors: becker kg. PLoS One. 2014 Jan 27;9(1):e84665. doi: 10.1371/journal.pone.0084665. eCollection 2014. PLoS One. 2014. PMID: 24475032 Free PMC article.
Therefore, a single injection of METH produced long-lasting changes in gene expression in the rodent NAc. The long-term increases in Crh, Cart, and Avp mRNA expression suggest that METH exposure produced prolonged activation of the endogenous stress system. ...
Therefore, a single injection of METH produced long-lasting changes in gene expression in the rodent NAc. The long-term increases in …
Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome.
Fok WC, Chen Y, Bokov A, Zhang Y, Salmon AB, Diaz V, Javors M, Wood WH 3rd, Zhang Y, Becker KG, Pérez VI, Richardson A. Fok WC, et al. Among authors: becker kg. PLoS One. 2014 Jan 7;9(1):e83988. doi: 10.1371/journal.pone.0083988. eCollection 2014. PLoS One. 2014. PMID: 24409289 Free PMC article.
Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the increase in the hazard for mortality (i.e., the rate of aging) term in the Gompertz mortality analysis. To identify the pathways that could be responsible …
Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the increase in the hazar …
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