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A subpopulation of lipogenic brown adipocytes drives thermogenic memory.
Lundgren P, Sharma PV, Dohnalová L, Coleman K, Uhr GT, Kircher S, Litichevskiy L, Bahnsen K, Descamps HC, Demetriadou C, Chan J, Chellappa K, Cox TO, Heyman Y, Pather SR, Shoffler C, Petucci C, Shalem O, Raj A, Baur JA, Snyder NW, Wellen KE, Levy M, Seale P, Li M, Thaiss CA. Lundgren P, et al. Among authors: baur ja. Nat Metab. 2023 Oct;5(10):1691-1705. doi: 10.1038/s42255-023-00893-w. Epub 2023 Oct 2. Nat Metab. 2023. PMID: 37783943
Sustained responses to transient environmental stimuli are important for survival. The mechanisms underlying long-term adaptations to temporary shifts in abiotic factors remain incompletely understood. ...Overall, our data highlight the importance of heterogenous brown adi …
Sustained responses to transient environmental stimuli are important for survival. The mechanisms underlying long-term adaptations to …
Drugs Targeting Mechanisms of Aging to Delay Age-Related Disease and Promote Healthspan: Proceedings of a National Institute on Aging Workshop.
Espinoza SE, Khosla S, Baur JA, de Cabo R, Musi N. Espinoza SE, et al. Among authors: baur ja. J Gerontol A Biol Sci Med Sci. 2023 Jun 16;78(Suppl 1):53-60. doi: 10.1093/gerona/glad034. J Gerontol A Biol Sci Med Sci. 2023. PMID: 37325957
However, much further research is needed to demonstrate benefits and general safety for wider use, the appropriate target populations, and longer-term outcomes....
However, much further research is needed to demonstrate benefits and general safety for wider use, the appropriate target populations, and l …
The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis.
Jaiswal N, Gavin MG, Quinn WJ 3rd, Luongo TS, Gelfer RG, Baur JA, Titchenell PM. Jaiswal N, et al. Among authors: baur ja. Mol Metab. 2019 Oct;28:1-13. doi: 10.1016/j.molmet.2019.08.001. Epub 2019 Aug 5. Mol Metab. 2019. PMID: 31444134 Free PMC article.
Similar effects on insulin sensitivity were observed in mice with prolonged deletion (4 weeks) of both skeletal muscle Akt isoforms selectively in adulthood. Conversely, short term deletion (2 weeks) of skeletal muscle specific Akt in adult muscles impaired insulin toleran …
Similar effects on insulin sensitivity were observed in mice with prolonged deletion (4 weeks) of both skeletal muscle Akt isoforms selectiv …
Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network.
Côté CD, Rasmussen BA, Duca FA, Zadeh-Tahmasebi M, Baur JA, Daljeet M, Breen DM, Filippi BM, Lam TK. Côté CD, et al. Among authors: baur ja. Nat Med. 2015 May;21(5):498-505. doi: 10.1038/nm.3821. Epub 2015 Apr 6. Nat Med. 2015. PMID: 25849131
In addition to the effects of duodenally acting resveratrol in an acute 3 d HFD-fed model of insulin resistance, we also found that short-term infusion of resveratrol into the duodenum lowered HGP in two other rat models of insulin resistance--a 28 d HFD-induced model of o …
In addition to the effects of duodenally acting resveratrol in an acute 3 d HFD-fed model of insulin resistance, we also found that short- …
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.
Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, González-Reyes JA, Villalba JM, Baur JA, Elliott P, Westphal C, Vlasuk GP, Ellis JL, Sinclair DA, Bernier M, de Cabo R. Mercken EM, et al. Among authors: baur ja. Aging Cell. 2014 Oct;13(5):787-96. doi: 10.1111/acel.12220. Epub 2014 Jun 16. Aging Cell. 2014. PMID: 24931715 Free PMC article.
This is accompanied by improvements in health, including enhanced motor coordination, performance, bone mineral density, and insulin sensitivity associated with higher mitochondrial content and decreased inflammation. Short-term SRT2104 treatment preserves bone and muscle …
This is accompanied by improvements in health, including enhanced motor coordination, performance, bone mineral density, and insulin sensiti …
Extended wakefulness: compromised metabolics in and degeneration of locus ceruleus neurons.
Zhang J, Zhu Y, Zhan G, Fenik P, Panossian L, Wang MM, Reid S, Lai D, Davis JG, Baur JA, Veasey S. Zhang J, et al. Among authors: baur ja. J Neurosci. 2014 Mar 19;34(12):4418-31. doi: 10.1523/JNEUROSCI.5025-12.2014. J Neurosci. 2014. PMID: 24647961 Free PMC article.
Modern society enables a shortening of sleep times, yet long-term consequences of extended wakefulness on the brain are largely unknown. ...
Modern society enables a shortening of sleep times, yet long-term consequences of extended wakefulness on the brain are largely unkno …
SRT1720 improves survival and healthspan of obese mice.
Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, de Cabo R. Minor RK, et al. Among authors: baur ja. Sci Rep. 2011;1:70. doi: 10.1038/srep00070. Epub 2011 Aug 18. Sci Rep. 2011. PMID: 22355589 Free PMC article.
Using a conditional SIRT1 knockout mouse and specific gene knockdowns we show SRT1720 affects mitochondrial respiration in a Sirt1- and PGC-1alpha-dependent manner. These findings indicate that SRT1720 has long-term benefits and demonstrate for the first time the feasibili …
Using a conditional SIRT1 knockout mouse and specific gene knockdowns we show SRT1720 affects mitochondrial respiration in a Sirt1- and PGC- …