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Choline Supplementation Partially Restores Dendrite Structural Complexity in Developing Iron-Deficient Mouse Hippocampal Neurons.
J Nutr. 2022 Mar 3;152(3):747-757. doi: 10.1093/jn/nxab429.
J Nutr. 2022.
PMID: 34958369
Free PMC article.
Simplified hippocampal neuron dendrite structure is a key mechanism underlying these long-term impairments. Early life choline supplementation, with postnatal iron repletion, improves learning/memory performance in formerly iron-deficient (ID) rats. ...
Simplified hippocampal neuron dendrite structure is a key mechanism underlying these long-term impairments. Early life choline supple …
Chronic Energy Depletion due to Iron Deficiency Impairs Dendritic Mitochondrial Motility during Hippocampal Neuron Development.
Bastian TW, von Hohenberg WC, Georgieff MK, Lanier LM.
Bastian TW, et al.
J Neurosci. 2019 Jan 30;39(5):802-813. doi: 10.1523/JNEUROSCI.1504-18.2018. Epub 2018 Dec 6.
J Neurosci. 2019.
PMID: 30523068
Free PMC article.
At 18 DIV, the overall density of mitochondria within terminal dendritic branches was reduced in DFO-treated neurons, which may contribute to the long-term deficits in connectivity and synaptic function following early-life iron deficiency. ...
At 18 DIV, the overall density of mitochondria within terminal dendritic branches was reduced in DFO-treated neurons, which may contribute t …
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Eltrombopag, a thrombopoietin mimetic, crosses the blood-brain barrier and impairs iron-dependent hippocampal neuron dendrite development.
Bastian TW, Duck KA, Michalopoulos GC, Chen MJ, Liu ZJ, Connor JR, Lanier LM, Sola-Visner MC, Georgieff MK.
Bastian TW, et al.
J Thromb Haemost. 2017 Mar;15(3):565-574. doi: 10.1111/jth.13602. Epub 2017 Feb 16.
J Thromb Haemost. 2017.
PMID: 28005311
Free PMC article.
Iron deficiency (ID) is particularly deleterious during brain development, impairing neuronal myelination, dopamine signaling and dendritic maturation and ultimately impairing long-term neurological function (e.g. hippocampal-dependent learning and memory). ...
Iron deficiency (ID) is particularly deleterious during brain development, impairing neuronal myelination, dopamine signaling and dendritic …
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Iron Deficiency Impairs Developing Hippocampal Neuron Gene Expression, Energy Metabolism, and Dendrite Complexity.
Bastian TW, von Hohenberg WC, Mickelson DJ, Lanier LM, Georgieff MK.
Bastian TW, et al.
Dev Neurosci. 2016;38(4):264-276. doi: 10.1159/000448514. Epub 2016 Sep 27.
Dev Neurosci. 2016.
PMID: 27669335
Free PMC article.
ID is particularly deleterious during early-life brain development, leading to long-term neurological impairments including deficits in hippocampus-mediated learning and memory. ...
ID is particularly deleterious during early-life brain development, leading to long-term neurological impairments including deficits …
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Fetal and neonatal iron deficiency but not copper deficiency increases vascular complexity in the developing rat brain.
Bastian TW, Santarriaga S, Nguyen TA, Prohaska JR, Georgieff MK, Anderson GW.
Bastian TW, et al.
Nutr Neurosci. 2015;18(8):365-75. doi: 10.1179/1476830515Y.0000000037. Epub 2015 Jul 15.
Nutr Neurosci. 2015.
PMID: 26177275
Free PMC article.
At least initially, this is probably an adaptive response to maintain metabolic substrate homeostasis in the developing iron-deficient brain. However, this may also contribute to long-term neurodevelopmental deficits....
At least initially, this is probably an adaptive response to maintain metabolic substrate homeostasis in the developing iron-deficient brain …
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