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p17/C18-ceramide-mediated mitophagy is an endogenous neuroprotective response in preclinical and clinical brain injury.
Karakaya E, Oleinik N, Edwards J, Tomberlin J, Barker RB, Berber B, Ericsson M, Alsudani H, Ergul A, Beyaz S, Lemasters JJ, Ogretmen B, Albayram O. Karakaya E, et al. Among authors: barker rb. PNAS Nexus. 2024 Feb 7;3(2):pgae018. doi: 10.1093/pnasnexus/pgae018. eCollection 2024 Feb. PNAS Nexus. 2024. PMID: 38328780 Free PMC article.
Repeat concussions (or repetitive mild traumatic brain injury [rmTBI]) are complex pathological processes consisting of a primary insult and long-term secondary complications and are also a prerequisite for chronic traumatic encephalopathy (CTE). ...Using a novel repetitiv …
Repeat concussions (or repetitive mild traumatic brain injury [rmTBI]) are complex pathological processes consisting of a primary insult and …
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study.
C-MORE/PHOSP-COVID Collaborative Group. C-MORE/PHOSP-COVID Collaborative Group. Lancet Respir Med. 2023 Nov;11(11):1003-1019. doi: 10.1016/S2213-2600(23)00262-X. Epub 2023 Sep 22. Lancet Respir Med. 2023. PMID: 37748493 Free PMC article.
INTERPRETATION: After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeu …
INTERPRETATION: After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings e …
Perseverance with home-based upper limb practice after stroke: perspectives of stroke survivors and their significant others.
Neibling B, Hayward KS, Smith M, Chapman P, Barker RN. Neibling B, et al. Among authors: barker rn. Disabil Rehabil. 2024 Mar;46(6):1103-1111. doi: 10.1080/09638288.2023.2191011. Epub 2023 May 5. Disabil Rehabil. 2024. PMID: 37144251
All facets need to be addressed in the design of strategies to enhance stroke survivors' ability to persevere and in turn, enhance their potential for continued upper limb recovery.IMPLICATIONS FOR REHABILITATIONMany stroke survivors do not persevere with long-term home-ba …
All facets need to be addressed in the design of strategies to enhance stroke survivors' ability to persevere and in turn, enhance their pot …
Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study.
Jackson C, Stewart ID, Plekhanova T, Cunningham PS, Hazel AL, Al-Sheklly B, Aul R, Bolton CE, Chalder T, Chalmers JD, Chaudhuri N, Docherty AB, Donaldson G, Edwardson CL, Elneima O, Greening NJ, Hanley NA, Harris VC, Harrison EM, Ho LP, Houchen-Wolloff L, Howard LS, Jolley CJ, Jones MG, Leavy OC, Lewis KE, Lone NI, Marks M, McAuley HJC, McNarry MA, Patel BV, Piper-Hanley K, Poinasamy K, Raman B, Richardson M, Rivera-Ortega P, Rowland-Jones SL, Rowlands AV, Saunders RM, Scott JT, Sereno M, Shah AM, Shikotra A, Singapuri A, Stanel SC, Thorpe M, Wootton DG, Yates T, Gisli Jenkins R, Singh SJ, Man WD, Brightling CE, Wain LV, Porter JC, Thompson AAR, Horsley A, Molyneaux PL, Evans RA, Jones SE, Rutter MK, Blaikley JF; PHOSP-COVID Study Collaborative Group. Jackson C, et al. Lancet Respir Med. 2023 Aug;11(8):673-684. doi: 10.1016/S2213-2600(23)00124-8. Epub 2023 Apr 15. Lancet Respir Med. 2023. PMID: 37072018 Free PMC article.
Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study.
McAuley HJC, Evans RA, Bolton CE, Brightling CE, Chalmers JD, Docherty AB, Elneima O, Greenhaff PL, Gupta A, Harris VC, Harrison EM, Ho LP, Horsley A, Houchen-Wolloff L, Jolley CJ, Leavy OC, Lone NI, Man WD, Marks M, Parekh D, Poinasamy K, Quint JK, Raman B, Richardson M, Saunders RM, Sereno M, Shikotra A, Singapuri A, Singh SJ, Steiner M, Tan AL, Wain LV, Welch C, Whitney J, Witham MD, Lord J, Greening NJ; PHOSP-COVID Study Collaborative Group. McAuley HJC, et al. EClinicalMedicine. 2023 Mar 11;57:101896. doi: 10.1016/j.eclinm.2023.101896. eCollection 2023 Mar. EClinicalMedicine. 2023. PMID: 36936404 Free PMC article.
BACKGROUND: The scale of COVID-19 and its well documented long-term sequelae support a need to understand long-term outcomes including frailty. ...
BACKGROUND: The scale of COVID-19 and its well documented long-term sequelae support a need to understand long-term outcomes i …
Towards a multi-arm multi-stage platform trial of disease modifying approaches in Parkinson's disease.
Foltynie T, Gandhi S, Gonzalez-Robles C, Zeissler ML, Mills G, Barker R, Carpenter J, Schrag A, Schapira A, Bandmann O, Mullin S, Duffen J, McFarthing K, Chataway J, Parmar M, Carroll C; EJS ACT-PD Consortium. Foltynie T, et al. Among authors: barker r. Brain. 2023 Jul 3;146(7):2717-2722. doi: 10.1093/brain/awad063. Brain. 2023. PMID: 36856727 Free PMC article.
Beyond this, there must be robust processes of treatment selection, and consensus derived measures to confirm target engagement and interim assessments of efficacy, as well as consideration of the infrastructure needed to support recruitment, and the long-term funding and …
Beyond this, there must be robust processes of treatment selection, and consensus derived measures to confirm target engagement and interim …
Which interventions are effective at decreasing or increasing emergency department attendances or hospital admissions from long-term care facilities? A systematic review.
Searle B, Barker RO, Stow D, Spiers GF, Pearson F, Hanratty B. Searle B, et al. Among authors: barker ro. BMJ Open. 2023 Feb 2;13(2):e064914. doi: 10.1136/bmjopen-2022-064914. BMJ Open. 2023. PMID: 36731926 Free PMC article.
OBJECTIVE: UK long-term care facility residents account for 185 000 emergency hospital admissions each year. ...Advance care planning and goals of care setting appear to be effective at reducing hospitalisations from long-term care facilities. Other effective interv …
OBJECTIVE: UK long-term care facility residents account for 185 000 emergency hospital admissions each year. ...Advance care planning …
Co-creation of a student-implemented allied health service in a First Nations remote community of East Arnhem Land, Australia.
Barker R, Witt S, Bird K, Stothers K, Armstrong E, Yunupingu MD, Marika ED, Brown L, Moore R, Campbell N. Barker R, et al. Aust J Rural Health. 2022 Dec;30(6):782-794. doi: 10.1111/ajr.12938. Epub 2022 Nov 15. Aust J Rural Health. 2022. PMID: 36378458 Free PMC article.
Recommendations for the service included: continuing the reciprocal learning service model in the long term; expanding to include all age groups; and connecting with visiting and community-based services. ...
Recommendations for the service included: continuing the reciprocal learning service model in the long term; expanding to include all …
Genomic Characterization of Potential Plant Growth-Promoting Features of Sphingomonas Strains Isolated from the International Space Station.
Lombardino J, Bijlani S, Singh NK, Wood JM, Barker R, Gilroy S, Wang CCC, Venkateswaran K. Lombardino J, et al. Among authors: barker r. Microbiol Spectr. 2022 Feb 23;10(1):e0199421. doi: 10.1128/spectrum.01994-21. Epub 2022 Jan 12. Microbiol Spectr. 2022. PMID: 35019675 Free PMC article.
Characterizing these biotechnologically important microorganisms found on the ISS and harnessing their key features will aid in the development of self-sustainable long-term space missions in the future. IMPORTANCESphingomonas is ubiquitous in nature, including the anthrop …
Characterizing these biotechnologically important microorganisms found on the ISS and harnessing their key features will aid in the developm …
Long-term Effectiveness of Adjuvant Treatment With Catechol-O-Methyltransferase or Monoamine Oxidase B Inhibitors Compared With Dopamine Agonists Among Patients With Parkinson Disease Uncontrolled by Levodopa Therapy: The PD MED Randomized Clinical Trial.
Gray R, Patel S, Ives N, Rick C, Woolley R, Muzerengi S, Gray A, Jenkinson C, McIntosh E, Wheatley K, Williams A, Clarke CE; PD MED Collaborative Group. Gray R, et al. JAMA Neurol. 2022 Feb 1;79(2):131-140. doi: 10.1001/jamaneurol.2021.4736. JAMA Neurol. 2022. PMID: 34962574 Free PMC article. Clinical Trial.
Among these patients, it is uncertain which drug class is more effective as adjuvant therapy. OBJECTIVE: To compare the long-term effects on patient-rated quality of life of adding a dopamine agonist vs a dopamine reuptake inhibitor (DRI), either a monoamine oxidase type B …
Among these patients, it is uncertain which drug class is more effective as adjuvant therapy. OBJECTIVE: To compare the long-term eff …
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