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Behavioral Analysis of NMDAR Function in Rodents: Tests of Long-Term Spatial Memory.
Bannerman DM, Barkus C, Eltokhi A. Bannerman DM, et al. Methods Mol Biol. 2024;2799:107-138. doi: 10.1007/978-1-0716-3830-9_7. Methods Mol Biol. 2024. PMID: 38727905
NMDAR-dependent forms of synaptic plasticity in brain regions like the hippocampus are widely believed to provide the neural substrate for long-term associative memory formation. However, the experimental data are equivocal at best and may suggest a more nuanced role for N …
NMDAR-dependent forms of synaptic plasticity in brain regions like the hippocampus are widely believed to provide the neural substrate for l …
Distinct effects of AMPAR subunit depletion on spatial memory.
Eltokhi A, Bertocchi I, Rozov A, Jensen V, Borchardt T, Taylor A, Proenca CC, Rawlins JNP, Bannerman DM, Sprengel R. Eltokhi A, et al. Among authors: bannerman dm. iScience. 2023 Oct 1;26(11):108116. doi: 10.1016/j.isci.2023.108116. eCollection 2023 Nov 17. iScience. 2023. PMID: 37876813 Free PMC article.
In the Morris water maze (MWM), Gria1/3(deltaFb) mice showed profound long-term memory deficits, in marked contrast to the normal MWM learning previously seen in single Gria1(-/-) and Gria3(-/-) knockout mice. Our results suggest a redundancy of function within the pool of …
In the Morris water maze (MWM), Gria1/3(deltaFb) mice showed profound long-term memory deficits, in marked contrast to the normal MWM …
GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia.
Harrison PJ, Bannerman DM. Harrison PJ, et al. Among authors: bannerman dm. Mol Psychiatry. 2023 Sep;28(9):3568-3572. doi: 10.1038/s41380-023-02265-y. Epub 2023 Sep 22. Mol Psychiatry. 2023. PMID: 37736757 Free PMC article. Review.
We suggest that one consequence of NR2A dysfunction is impairment in a form of hippocampal synaptic plasticity, producing deficits in short-term habituation and thence elevated and dysregulated levels of attention, a phenotype of relevance to schizophrenia and its cognitiv …
We suggest that one consequence of NR2A dysfunction is impairment in a form of hippocampal synaptic plasticity, producing deficits in short- …
Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience.
Panayi MC, Boerner T, Jahans-Price T, Huber A, Sprengel R, Gilmour G, Sanderson DJ, Harrison PJ, Walton ME, Bannerman DM. Panayi MC, et al. Among authors: bannerman dm. Mol Psychiatry. 2023 Feb;28(2):579-587. doi: 10.1038/s41380-022-01861-8. Epub 2022 Dec 2. Mol Psychiatry. 2023. PMID: 36460723 Free PMC article.
GluA1 knockout (Gria1(-/-)) mice provide a model of impaired synaptic plasticity in schizophrenia and exhibit a selective deficit in a form of short-term memory which underlies short-term habituation. As such, these mice are unable to reduce attention to recently pr …
GluA1 knockout (Gria1(-/-)) mice provide a model of impaired synaptic plasticity in schizophrenia and exhibit a selective deficit in a form …
Psilocin acutely alters sleep-wake architecture and cortical brain activity in laboratory mice.
Thomas CW, Blanco-Duque C, Bréant BJ, Goodwin GM, Sharp T, Bannerman DM, Vyazovskiy VV. Thomas CW, et al. Among authors: bannerman dm. Transl Psychiatry. 2022 Feb 23;12(1):77. doi: 10.1038/s41398-022-01846-9. Transl Psychiatry. 2022. PMID: 35197453 Free PMC article.
Growing evidence suggests that a single psychedelic experience can positively impact long-term psychological well-being, with relevance for the treatment of psychiatric disorders, including depression. ...Administration of psilocin led to delayed REM sleep onset and reduce …
Growing evidence suggests that a single psychedelic experience can positively impact long-term psychological well-being, with relevan …
Deletion of AMPA receptor GluA1 subunit gene (Gria1) causes circadian rhythm disruption and aberrant responses to environmental cues.
Ang G, Brown LA, Tam SKE, Davies KE, Foster RG, Harrison PJ, Sprengel R, Vyazovskiy VV, Oliver PL, Bannerman DM, Peirson SN. Ang G, et al. Among authors: bannerman dm. Transl Psychiatry. 2021 Nov 15;11(1):588. doi: 10.1038/s41398-021-01690-3. Transl Psychiatry. 2021. PMID: 34782594 Free PMC article.
Finally, in the spontaneous odour recognition task GluA1 knockouts' short-term memory was impaired due to enhanced attention to the recently encountered familiar odour. ...
Finally, in the spontaneous odour recognition task GluA1 knockouts' short-term memory was impaired due to enhanced attention to the r …
Postnatal prebiotic supplementation in rats affects adult anxious behaviour, hippocampus, electrophysiology, metabolomics, and gut microbiota.
Spitzer SO, Tkacz A, Savignac HM, Cooper M, Giallourou N, Mann EO, Bannerman DM, Swann JR, Anthony DC, Poole PS, Burnet PWJ. Spitzer SO, et al. Among authors: bannerman dm. iScience. 2021 Sep 10;24(10):103113. doi: 10.1016/j.isci.2021.103113. eCollection 2021 Oct 22. iScience. 2021. PMID: 34611610 Free PMC article.
Our data are the first to show that prebiotic administration to rats during a specific postnatal period has long-term effects on behavior and hippocampal physiology. The study also suggests that early-life prebiotic intake may affect host brain function through the reducti …
Our data are the first to show that prebiotic administration to rats during a specific postnatal period has long-term effects on beha …
Dim light in the evening causes coordinated realignment of circadian rhythms, sleep, and short-term memory.
Tam SKE, Brown LA, Wilson TS, Tir S, Fisk AS, Pothecary CA, van der Vinne V, Foster RG, Vyazovskiy VV, Bannerman DM, Harrington ME, Peirson SN. Tam SKE, et al. Among authors: bannerman dm. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2101591118. doi: 10.1073/pnas.2101591118. Proc Natl Acad Sci U S A. 2021. PMID: 34556572 Free PMC article.
DLE delays molecular clock rhythms in the heart, liver, adrenal gland, and dorsal hippocampus. It also reverses short-term recognition memory performance, which is associated with changes in preceding sleep history. ...Together, our data show that DLE causes coordinated re …
DLE delays molecular clock rhythms in the heart, liver, adrenal gland, and dorsal hippocampus. It also reverses short-term recognitio …
Hippocampal-prefrontal coherence mediates working memory and selective attention at distinct frequency bands and provides a causal link between schizophrenia and its risk gene GRIA1.
Bygrave AM, Jahans-Price T, Wolff AR, Sprengel R, Kullmann DM, Bannerman DM, Kätzel D. Bygrave AM, et al. Among authors: bannerman dm. Transl Psychiatry. 2019 Apr 18;9(1):142. doi: 10.1038/s41398-019-0471-0. Transl Psychiatry. 2019. PMID: 31000699 Free PMC article.
Mice lacking the putative schizophrenia risk gene GRIA1 (Gria1(-/-)), which encodes GLUA1, show strongly impaired spatial working memory and elevated selective attention owing to a deficit in stimulus-specific short-term habituation. A failure of short-term habituat …
Mice lacking the putative schizophrenia risk gene GRIA1 (Gria1(-/-)), which encodes GLUA1, show strongly impaired spatial working memory and …
67 results