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Elevated insulin growth factor-1 in dentate gyrus induces cognitive deficits in pre-term newborns.
Sharma DR, Cheng B, Jaiswal MK, Zhang X, Kumar A, Parikh N, Singh D, Sheth H, Varghese M, Dobrenis K, Zhang X, Hof PR, Stanton PK, Ballabh P. Sharma DR, et al. Among authors: ballabh p. Cereb Cortex. 2023 May 9;33(10):6449-6464. doi: 10.1093/cercor/bhac516. Cereb Cortex. 2023. PMID: 36646459 Free PMC article.
Here, we show that prematurity and associated neonatal stress disrupt dentate gyrus (DG) development and induce long-term cognitive deficits and that these effects are mediated by insulin growth factor-1 (IGF1). ...However, the density of glutamatergic synapses, mature den …
Here, we show that prematurity and associated neonatal stress disrupt dentate gyrus (DG) development and induce long-term cognitive d …
Reduced Hippocampal Dendrite Branching, Spine Density and Neurocognitive Function in Premature Rabbits, and Reversal with Estrogen or TrkB Agonist Treatment.
Klebe D, Tibrewal M, Sharma DR, Vanaparthy R, Krishna S, Varghese M, Cheng B, Mouton PR, Velíšková J, Dobrenis K, Hof PR, Ballabh P. Klebe D, et al. Among authors: ballabh p. Cereb Cortex. 2019 Dec 17;29(12):4932-4947. doi: 10.1093/cercor/bhz033. Cereb Cortex. 2019. PMID: 30877788 Free PMC article.
Neurobehavioral tests showed that both premature-birth and formula-feeding with non-maternal care led to increased anxiety behavior, poor social interaction, and lack of novelty preference compared with term-kits. Dendritic branching and number of total or mushroom …
Neurobehavioral tests showed that both premature-birth and formula-feeding with non-maternal care led to increased anxiety behavior, …
Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline.
Valcarcel-Ares MN, Tucsek Z, Kiss T, Giles CB, Tarantini S, Yabluchanskiy A, Balasubramanian P, Gautam T, Galvan V, Ballabh P, Richardson A, Freeman WM, Wren JD, Deak F, Ungvari Z, Csiszar A. Valcarcel-Ares MN, et al. Among authors: ballabh p. J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):290-298. doi: 10.1093/gerona/gly127. J Gerontol A Biol Sci Med Sci. 2019. PMID: 29893815 Free PMC article.
To test the hypothesis that synergistic effects of obesity and aging on inflammatory processes exert deleterious effects on hippocampal function, young and aged C57BL/6 mice were rendered obese by chronic feeding of a high-fat diet followed by assessment of learning and memory fu …
To test the hypothesis that synergistic effects of obesity and aging on inflammatory processes exert deleterious effects on hippocampal func …
Disruption of Interneuron Neurogenesis in Premature Newborns and Reversal with Estrogen Treatment.
Tibrewal M, Cheng B, Dohare P, Hu F, Mehdizadeh R, Wang P, Zheng D, Ungvari Z, Ballabh P. Tibrewal M, et al. Among authors: ballabh p. J Neurosci. 2018 Jan 31;38(5):1100-1113. doi: 10.1523/JNEUROSCI.1875-17.2017. Epub 2017 Dec 15. J Neurosci. 2018. PMID: 29246927 Free PMC article.
We found that both total and cycling Nkx2.1(+), Dlx2(+), and Sox2(+) cells were more abundant in the MGEs of preterm rabbits at D3 compared with term rabbits at D0, but not in D7 preterm relative to D4 term pups. Total Nkx2.1(+) progenitors were also more numerous i …
We found that both total and cycling Nkx2.1(+), Dlx2(+), and Sox2(+) cells were more abundant in the MGEs of preterm rabbits at D3 compared …
Postnatal glucocorticoid-induced hypomyelination, gliosis, and neurologic deficits are dose-dependent, preparation-specific, and reversible.
Zia MT, Vinukonda G, Vose LR, Bhimavarapu BB, Iacobas S, Pandey NK, Beall AM, Dohare P, LaGamma EF, Iacobas DA, Ballabh P. Zia MT, et al. Among authors: ballabh p. Exp Neurol. 2015 Jan;263:200-13. doi: 10.1016/j.expneurol.2014.09.013. Epub 2014 Sep 28. Exp Neurol. 2015. PMID: 25263581 Free PMC article.
However, the effect of GC dose and preparation (dexamethasone versus betamethasone) on short and long-term neurological outcomes remains undetermined, and the mechanisms of GC-induced brain injury are unclear. ...
However, the effect of GC dose and preparation (dexamethasone versus betamethasone) on short and long-term neurological outcomes rema …
Prenatal betamethasone does not affect glutamatergic or GABAergic neurogenesis in preterm newborns.
Vose LR, Vinukonda G, Diamond D, Korumilli R, Hu F, Zia MT, Hevner R, Ballabh P. Vose LR, et al. Among authors: ballabh p. Neuroscience. 2014 Jun 13;270:148-57. doi: 10.1016/j.neuroscience.2014.04.009. Epub 2014 Apr 13. Neuroscience. 2014. PMID: 24735821 Free PMC article.
To test our hypotheses, we treated pregnant rabbits with betamethasone at E27 and E28, delivered the pups at E29 (term=32d), and assessed neurogenesis at birth and postnatal day 3. ...However, there was a transient elevation in Mash1 protein in betamethasone-treated …
To test our hypotheses, we treated pregnant rabbits with betamethasone at E27 and E28, delivered the pups at E29 (term=32d), and asse …
Neurogenesis continues in the third trimester of pregnancy and is suppressed by premature birth.
Malik S, Vinukonda G, Vose LR, Diamond D, Bhimavarapu BB, Hu F, Zia MT, Hevner R, Zecevic N, Ballabh P. Malik S, et al. Among authors: ballabh p. J Neurosci. 2013 Jan 9;33(2):411-23. doi: 10.1523/JNEUROSCI.4445-12.2013. J Neurosci. 2013. PMID: 23303921 Free PMC article.
However, their densities consistently decreased from 16 through 28 gw. To determine the effect of premature birth on neurogenesis, we used a rabbit model and compared preterm [embryonic day 29 (E29), 3 d old] and term (E32, <2 h old) pups at an equivalent postcon …
However, their densities consistently decreased from 16 through 28 gw. To determine the effect of premature birth on neurogenesis, we …
Effect of prenatal glucocorticoids on cerebral vasculature of the developing brain.
Vinukonda G, Dummula K, Malik S, Hu F, Thompson CI, Csiszar A, Ungvari Z, Ballabh P. Vinukonda G, et al. Among authors: ballabh p. Stroke. 2010 Aug;41(8):1766-73. doi: 10.1161/STROKEAHA.110.588400. Epub 2010 Jul 8. Stroke. 2010. PMID: 20616316 Free PMC article.
METHODS: We treated pregnant rabbits with intramuscular betamethasone and delivered pups prematurely by cesarean section at E29 (term=32 days). Endothelial turnover, vascular density, pericyte coverage, glial fibrillary acidic protein-positive end feet, cell death, and gro …
METHODS: We treated pregnant rabbits with intramuscular betamethasone and delivered pups prematurely by cesarean section at E29 (term …
Consequences of intraventricular hemorrhage in a rabbit pup model.
Chua CO, Chahboune H, Braun A, Dummula K, Chua CE, Yu J, Ungvari Z, Sherbany AA, Hyder F, Ballabh P. Chua CO, et al. Among authors: ballabh p. Stroke. 2009 Oct;40(10):3369-77. doi: 10.1161/STROKEAHA.109.549212. Epub 2009 Aug 6. Stroke. 2009. PMID: 19661479 Free PMC article.
We asked whether induction of moderate-to-severe IVH in premature rabbit pups would produce long-term sequelae of cerebral palsy, posthemorrhagic hydrocephalus, reduced myelination, and gliosis. ...
We asked whether induction of moderate-to-severe IVH in premature rabbit pups would produce long-term sequelae of cerebral palsy, pos …
Postnatal betamethasone vs dexamethasone in premature infants with bronchopulmonary dysplasia: a pilot study.
DeCastro M, El-Khoury N, Parton L, Ballabh P, LaGamma EF. DeCastro M, et al. Among authors: ballabh p. J Perinatol. 2009 Apr;29(4):297-304. doi: 10.1038/jp.2008.194. Epub 2008 Dec 4. J Perinatol. 2009. PMID: 19052552
STUDY DESIGN: To test our hypothesis, we selected premature neonates with a birth weight <or=1000 g and a gestational age <or=29 weeks who were ventilated >10 postnatal days with an FiO(2)>0.4 and no ability to wean mechanical support for >or=3 consecutive d …
STUDY DESIGN: To test our hypothesis, we selected premature neonates with a birth weight <or=1000 g and a gestational age <or=2 …
14 results