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Bimekizumab treatment in biologic DMARD-naïve patients with active psoriatic arthritis: 52-week efficacy and safety results from the phase III, randomised, placebo-controlled, active reference BE OPTIMAL study.
Ritchlin CT, Coates LC, McInnes IB, Mease PJ, Merola JF, Tanaka Y, Asahina A, Gossec L, Gottlieb AB, Warren RB, Ink B, Bajracharya R, Shende V, Coarse J, Landewé RB. Ritchlin CT, et al. Among authors: bajracharya r. Ann Rheum Dis. 2023 Nov;82(11):1404-1414. doi: 10.1136/ard-2023-224431. Epub 2023 Sep 11. Ann Rheum Dis. 2023. PMID: 37696588 Free PMC article. Clinical Trial.
BKZ treatment has demonstrated superior efficacy versus placebo (PBO) at Week 16 in biologic disease-modifying antirheumatic drug (DMARD)-naive patients with active psoriatic arthritis (PsA). Here, we report long-term efficacy and safety to Week 52. METHODS: BE OPTIMAL com …
BKZ treatment has demonstrated superior efficacy versus placebo (PBO) at Week 16 in biologic disease-modifying antirheumatic drug (DMARD)-na …
Safety and Efficacy of Bimekizumab in Patients With Active Psoriatic Arthritis: Three-Year Results From a Phase IIb Randomized Controlled Trial and Its Open-Label Extension Study.
Coates LC, McInnes IB, Merola JF, Warren RB, Kavanaugh A, Gottlieb AB, Gossec L, Assudani D, Bajracharya R, Coarse J, Ink B, Ritchlin CT. Coates LC, et al. Among authors: bajracharya r. Arthritis Rheumatol. 2022 Dec;74(12):1959-1970. doi: 10.1002/art.42280. Epub 2022 Nov 18. Arthritis Rheumatol. 2022. PMID: 35829656 Free PMC article. Clinical Trial.
OBJECTIVE: To assess the long-term safety, tolerability, and efficacy of bimekizumab in active psoriatic arthritis (PsA). ...
OBJECTIVE: To assess the long-term safety, tolerability, and efficacy of bimekizumab in active psoriatic arthritis (PsA). ...
Long-term sex differences in all-cause and infection-specific mortality post hip fracture.
Bajracharya R, Guralnik JM, Shardell MD, Rathbun AM, Yamashita T, Hochberg MC, Gruber-Baldini AL, Magaziner JS, Orwig DL. Bajracharya R, et al. J Am Geriatr Soc. 2022 Jul;70(7):2107-2114. doi: 10.1111/jgs.17800. Epub 2022 Apr 12. J Am Geriatr Soc. 2022. PMID: 35415882 Free PMC article.
BACKGROUND: Mortality rates among men are double that of women in the first 2 years after hip fracture and may be related to more infections. Research has only examined differences in short-term mortality after hip fracture. Thus, the objective was to determine if long- …
BACKGROUND: Mortality rates among men are double that of women in the first 2 years after hip fracture and may be related to more infections …
SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans.
Mudd PA, Minervina AA, Pogorelyy MV, Turner JS, Kim W, Kalaidina E, Petersen J, Schmitz AJ, Lei T, Haile A, Kirk AM, Mettelman RC, Crawford JC, Nguyen THO, Rowntree LC, Rosati E, Richards KA, Sant AJ, Klebert MK, Suessen T, Middleton WD; SJTRC Study Team; Wolf J, Teefey SA, O'Halloran JA, Presti RM, Kedzierska K, Rossjohn J, Thomas PG, Ellebedy AH. Mudd PA, et al. Cell. 2022 Feb 17;185(4):603-613.e15. doi: 10.1016/j.cell.2021.12.026. Epub 2021 Dec 23. Cell. 2022. PMID: 35026152 Free PMC article.
Collectively, our results underscore the key role that robust T(FH) cell responses play in establishing long-term immunity by this efficacious human vaccine....
Collectively, our results underscore the key role that robust T(FH) cell responses play in establishing long-term immunity by this ef …
Exuberant fibroblast activity compromises lung function via ADAMTS4.
Boyd DF, Allen EK, Randolph AG, Guo XJ, Weng Y, Sanders CJ, Bajracharya R, Lee NK, Guy CS, Vogel P, Guan W, Li Y, Liu X, Novak T, Newhams MM, Fabrizio TP, Wohlgemuth N, Mourani PM; PALISI Pediatric Intensive Care Influenza (PICFLU) Investigators; Wight TN, Schultz-Cherry S, Cormier SA, Shaw-Saliba K, Pekosz A, Rothman RE, Chen KF, Yang Z, Webby RJ, Zhong N, Crawford JC, Thomas PG. Boyd DF, et al. Among authors: bajracharya r. Nature. 2020 Nov;587(7834):466-471. doi: 10.1038/s41586-020-2877-5. Epub 2020 Oct 28. Nature. 2020. PMID: 33116313 Free PMC article.
Here we demonstrate that respiratory viral infection induces distinct fibroblast activation states, which we term extracellular matrix (ECM)-synthesizing, damage-responsive and interferon-responsive states. ...
Here we demonstrate that respiratory viral infection induces distinct fibroblast activation states, which we term extracellular matri …
Patterns of Psychoactive Medication Use in Community-Dwelling Older Adults in the US in 2016: A Descriptive Cross-Sectional Study.
Bajracharya R, Qato DM. Bajracharya R, et al. J Aging Health. 2021 Jan;33(1-2):86-100. doi: 10.1177/0898264320959293. Epub 2020 Sep 22. J Aging Health. 2021. PMID: 32960115
Methods: Prevalence estimates of any use and long-term use were calculated. Chi-square and crude odds ratios were calculated to estimate differences in any use and long-term use of psychoactive medication by sociodemographic characteristics of respondents. ...Discus …
Methods: Prevalence estimates of any use and long-term use were calculated. Chi-square and crude odds ratios were calculated to estim …
Q-Learning Based Fair and Efficient Coexistence of LTE in Unlicensed Band.
Bajracharya R, Shrestha R, Kim SW. Bajracharya R, et al. Sensors (Basel). 2019 Jun 28;19(13):2875. doi: 10.3390/s19132875. Sensors (Basel). 2019. PMID: 31261702 Free PMC article.
The increased demand for spectrum resources for multimedia communications and a limited licensed spectrum have led to widespread concern regarding the operation of long term evolution (LTE) in the unlicensed (LTE-U) band for internet of things (IoT) systems. ...
The increased demand for spectrum resources for multimedia communications and a limited licensed spectrum have led to widespread concern reg …