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Generation and Characterization of the Drosophila melanogaster paralytic Gene Knock-Out as a Model for Dravet Syndrome.
Tapia A, Giachello CN, Palomino-Schätzlein M, Baines RA, Galindo MI. Tapia A, et al. Among authors: baines ra. Life (Basel). 2021 Nov 18;11(11):1261. doi: 10.3390/life11111261. Life (Basel). 2021. PMID: 34833136 Free PMC article.
These flies showed a heat-induced seizing phenotype, and sudden death in long term seizures. In addition to seizures, neuromuscular alterations were observed in climbing, flight, and walking tests. ...
These flies showed a heat-induced seizing phenotype, and sudden death in long term seizures. In addition to seizures, neuromuscular a …
Restoration of mutant bestrophin-1 expression, localisation and function in a polarised epithelial cell model.
Uggenti C, Briant K, Streit AK, Thomson S, Koay YH, Baines RA, Swanton E, Manson FD. Uggenti C, et al. Among authors: baines ra. Dis Model Mech. 2016 Nov 1;9(11):1317-1328. doi: 10.1242/dmm.024216. Epub 2016 Aug 12. Dis Model Mech. 2016. PMID: 27519691 Free PMC article.
The functional rescue achieved with 4PBA is significant because it suggests that this drug, which is already approved for long-term use in infants and adults, might represent a promising therapy for the treatment of ARB and other bestrophinopathies resulting from missense …
The functional rescue achieved with 4PBA is significant because it suggests that this drug, which is already approved for long-term u …
The roles of the dystrophin-associated glycoprotein complex at the synapse.
Pilgram GS, Potikanond S, Baines RA, Fradkin LG, Noordermeer JN. Pilgram GS, et al. Among authors: baines ra. Mol Neurobiol. 2010 Feb;41(1):1-21. doi: 10.1007/s12035-009-8089-5. Epub 2009 Nov 9. Mol Neurobiol. 2010. PMID: 19899002 Free PMC article. Review.
Furthermore, roles for the DGC have been established in consolidation of long-term spatial and recognition memory. The challenges ahead include the integration of the behavioral and mechanistic studies and the use of this information to identify therapeutic targets....
Furthermore, roles for the DGC have been established in consolidation of long-term spatial and recognition memory. The challenges ahe …
Neuronal homeostasis through translational control.
Baines RA. Baines RA. Mol Neurobiol. 2005 Oct;32(2):113-21. doi: 10.1385/MN:32:2:113. Mol Neurobiol. 2005. PMID: 16215276 Review.
These mechanisms include those contributing to dendritic structure, synaptic growth, neuronal excitability, and formation of long-term memory. This article describes these new studies and highlights the role of translational repression in regulation of neuronal processes t …
These mechanisms include those contributing to dendritic structure, synaptic growth, neuronal excitability, and formation of long-term …