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Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A - C-Raf.
Blair CM, Walsh NM, Littman BH, Marcoux FW, Baillie GS. Blair CM, et al. Among authors: baillie gs. BMC Cancer. 2019 Mar 25;19(1):266. doi: 10.1186/s12885-019-5489-4. BMC Cancer. 2019. PMID: 30909892 Free PMC article.
However, an un-met clinical need remains in B-Raf inhibitor resistant patients where first-generation B-Raf inhibitors provide only short-term disease control. In these cases, B-Raf inhibition leads to paradoxical activation of the C-Raf - MEK - ERK signalling pathway, fol …
However, an un-met clinical need remains in B-Raf inhibitor resistant patients where first-generation B-Raf inhibitors provide only short- …
Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.
Havekes R, Park AJ, Tolentino RE, Bruinenberg VM, Tudor JC, Lee Y, Hansen RT, Guercio LA, Linton E, Neves-Zaph SR, Meerlo P, Baillie GS, Houslay MD, Abel T. Havekes R, et al. Among authors: baillie gs. J Neurosci. 2016 Aug 24;36(34):8936-46. doi: 10.1523/JNEUROSCI.0248-16.2016. J Neurosci. 2016. PMID: 27559174 Free PMC article.
However, the functional role of specific compartmentalized PDE4 isoforms has not been examined in vivo Here, we show that increasing protein levels of the PDE4A5 isoform in mouse hippocampal excitatory neurons impairs a long-lasting form of hippocampal synaptic plasticity and att …
However, the functional role of specific compartmentalized PDE4 isoforms has not been examined in vivo Here, we show that increasing protein …
Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1.
Havekes R, Park AJ, Tudor JC, Luczak VG, Hansen RT, Ferri SL, Bruinenberg VM, Poplawski SG, Day JP, Aton SJ, Radwańska K, Meerlo P, Houslay MD, Baillie GS, Abel T. Havekes R, et al. Among authors: baillie gs. Elife. 2016 Aug 23;5:e13424. doi: 10.7554/eLife.13424. Elife. 2016. PMID: 27549340 Free PMC article.
Suppression of cofilin function prevents spine loss, deficits in hippocampal synaptic plasticity, and impairments in long-term memory caused by sleep deprivation. The elevated cofilin activity is caused by cAMP-degrading phosphodiesterase-4A5 (PDE4A5), which hampers cAMP-P …
Suppression of cofilin function prevents spine loss, deficits in hippocampal synaptic plasticity, and impairments in long-term memory …
Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition.
McGirr A, Lipina TV, Mun HS, Georgiou J, Al-Amri AH, Ng E, Zhai D, Elliott C, Cameron RT, Mullins JG, Liu F, Baillie GS, Clapcote SJ, Roder JC. McGirr A, et al. Among authors: baillie gs. Neuropsychopharmacology. 2016 Mar;41(4):1080-92. doi: 10.1038/npp.2015.240. Epub 2015 Aug 14. Neuropsychopharmacology. 2016. PMID: 26272049 Free PMC article.
In behavioral assays, PDE4B(Y358C) mice displayed decreased anxiety and increased exploration, as well as cognitive enhancement across several tests of learning and memory, consistent with synaptic changes including enhanced long-term potentiation and impaired depotentiati …
In behavioral assays, PDE4B(Y358C) mice displayed decreased anxiety and increased exploration, as well as cognitive enhancement across sever …
Can acetylcholinesterase activity be considered as a reliable biomarker for the assessment of cadmium-induced neurotoxicity?
Zarros A, Kalopita K, Tsakiris S, Baillie GS. Zarros A, et al. Among authors: baillie gs. Food Chem Toxicol. 2013 Jun;56:406-10. doi: 10.1016/j.fct.2013.02.048. Epub 2013 Mar 5. Food Chem Toxicol. 2013. PMID: 23474324
Goncalves et al. (2012) recently reported the findings of a long-awaited study on the effects of long-term dietary-induced exposure to cadmium (Cd) on the acetylcholinesterase (AChE) activity of adult rodents' brain regions. ...
Goncalves et al. (2012) recently reported the findings of a long-awaited study on the effects of long-term dietary-induced exposure t …
Gravin orchestrates protein kinase A and β2-adrenergic receptor signaling critical for synaptic plasticity and memory.
Havekes R, Canton DA, Park AJ, Huang T, Nie T, Day JP, Guercio LA, Grimes Q, Luczak V, Gelman IH, Baillie GS, Scott JD, Abel T. Havekes R, et al. Among authors: baillie gs. J Neurosci. 2012 Dec 12;32(50):18137-49. doi: 10.1523/JNEUROSCI.3612-12.2012. J Neurosci. 2012. PMID: 23238728 Free PMC article.
Here, we show that mice lacking the alpha-isoform of gravin have deficits in PKA-dependent long-lasting forms of hippocampal synaptic plasticity including beta2-adrenergic receptor-mediated plasticity, and selective impairments of long-term memory storage. Furthermore, bot …
Here, we show that mice lacking the alpha-isoform of gravin have deficits in PKA-dependent long-lasting forms of hippocampal synaptic plasti …
Sleep deprivation impairs cAMP signalling in the hippocampus.
Vecsey CG, Baillie GS, Jaganath D, Havekes R, Daniels A, Wimmer M, Huang T, Brown KM, Li XY, Descalzi G, Kim SS, Chen T, Shang YZ, Zhuo M, Houslay MD, Abel T. Vecsey CG, et al. Among authors: baillie gs. Nature. 2009 Oct 22;461(7267):1122-5. doi: 10.1038/nature08488. Nature. 2009. PMID: 19847264 Free PMC article.
cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling.
Huston E, Houslay TM, Baillie GS, Houslay MD. Huston E, et al. Among authors: baillie gs. Biochem Soc Trans. 2006 Aug;34(Pt 4):504-9. doi: 10.1042/BST0340504. Biochem Soc Trans. 2006. PMID: 16856845
The irreversible, Ca(2+)-dependent insertion of the N-terminal region of PDE4A1 into membranes provides 'long-term' memory of cell activation....
The irreversible, Ca(2+)-dependent insertion of the N-terminal region of PDE4A1 into membranes provides 'long-term' memory of cell ac …