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Multiscale Model of Mycobacterium tuberculosis Infection Maps Metabolite and Gene Perturbations to Granuloma Sterilization Predictions.
Pienaar E, Matern WM, Linderman JJ, Bader JS, Kirschner DE. Pienaar E, et al. Among authors: bader js. Infect Immun. 2016 Apr 22;84(5):1650-1669. doi: 10.1128/IAI.01438-15. Print 2016 May. Infect Immun. 2016. PMID: 26975995 Free PMC article.
Our results indicate that a nonreplicating phenotype, but not lipid inclusion formation, is important for long-term M. tuberculosis survival in granulomas. We used virtual M. tuberculosis knockouts to predict the impact of both metabolic enzyme inhibitors and metabolic pat …
Our results indicate that a nonreplicating phenotype, but not lipid inclusion formation, is important for long-term M. tuberculosis s …
PADPIN: protein-protein interaction networks of angiogenesis, arteriogenesis, and inflammation in peripheral arterial disease.
Chu LH, Vijay CG, Annex BH, Bader JS, Popel AS. Chu LH, et al. Among authors: bader js. Physiol Genomics. 2015 Aug;47(8):331-43. doi: 10.1152/physiolgenomics.00125.2014. Epub 2015 Jun 9. Physiol Genomics. 2015. PMID: 26058837 Free PMC article.
We constructed global protein-protein interaction networks of angiogenesis (Angiome), immune response (Immunome), and arteriogenesis (Arteriome) using our previously developed algorithm GeneHits. The term "PADPIN" refers to the angiome, immunome, and arteriome in PAD. ...
We constructed global protein-protein interaction networks of angiogenesis (Angiome), immune response (Immunome), and arteriogenesis (Arteri …
Systems biology-based identification of Mycobacterium tuberculosis persistence genes in mouse lungs.
Dutta NK, Bandyopadhyay N, Veeramani B, Lamichhane G, Karakousis PC, Bader JS. Dutta NK, et al. Among authors: bader js. mBio. 2014 Feb 18;5(1):e01066-13. doi: 10.1128/mBio.01066-13. mBio. 2014. PMID: 24549847 Free PMC article.
We developed computational algorithms that predict M. tuberculosis genes required for long-term survival in mouse lungs. As the input, we used high-throughput M. tuberculosis mutant library screen data, mycobacterial global transcriptional profiles in mice and macrophages, …
We developed computational algorithms that predict M. tuberculosis genes required for long-term survival in mouse lungs. As the input …
Early innate immunity determines outcome of Mycobacterium tuberculosis pulmonary infection in rabbits.
Subbian S, Bandyopadhyay N, Tsenova L, O'Brien P, Khetani V, Kushner NL, Peixoto B, Soteropoulos P, Bader JS, Karakousis PC, Fallows D, Kaplan G. Subbian S, et al. Among authors: bader js. Cell Commun Signal. 2013 Aug 19;11:60. doi: 10.1186/1478-811X-11-60. Cell Commun Signal. 2013. PMID: 23958185 Free PMC article.
CONCLUSIONS: We propose that differential regulation of the inflammation-associated innate immune response and related gene expression changes seen at 3 hours determine the long term outcome of Mtb infection in rabbit lungs....
CONCLUSIONS: We propose that differential regulation of the inflammation-associated innate immune response and related gene expression chang …