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Sodium ferrous citrate and 5-aminolevulinic acid improve type 2 diabetes by maintaining muscle and mitochondrial health.
Kitamura N, Zhang S, Morel JD, Nagano U, Taworntawat T, Hosoda S, Nakamura A, Ogawa Y, Benegiamo G, Auwerx J, Tsubota K, Yokoyama Y, Watanabe M. Kitamura N, et al. Among authors: auwerx j. Obesity (Silver Spring). 2023 Apr;31(4):1038-1049. doi: 10.1002/oby.23705. Epub 2023 Feb 23. Obesity (Silver Spring). 2023. PMID: 36823345
In addition, SFC + ALA prevented the decline in mitochondrial DNA copy number by enhancing mitochondrial DNA maintenance and antioxidant transcription activity, both of which are impaired in high-fat diet-fed mice during long-term fasting. CONCLUSIONS: These findings sugge …
In addition, SFC + ALA prevented the decline in mitochondrial DNA copy number by enhancing mitochondrial DNA maintenance and antioxidant tra …
Mitochondrial and NAD+ metabolism predict recovery from acute kidney injury in a diverse mouse population.
Morel JD, Sleiman MB, Li TY, von Alvensleben G, Bachmann AM, Hofer D, Broeckx E, Ma JY, Carreira V, Chen T, Azhar N, Gonzalez-Villalobos RA, Breyer M, Reilly D, Mullican S, Auwerx J. Morel JD, et al. Among authors: auwerx j. JCI Insight. 2023 Feb 8;8(3):e164626. doi: 10.1172/jci.insight.164626. JCI Insight. 2023. PMID: 36752209 Free PMC article.
We measured plasma and urine parameters, as well as renal histopathology and mRNA expression data, at 1, 2, and 6 weeks after injury, covering the early recovery and long-term remission. We observed an extensive strain-specific response ranging from complete resistance of …
We measured plasma and urine parameters, as well as renal histopathology and mRNA expression data, at 1, 2, and 6 weeks after injury, coveri …
The Detection of Early Epigenetic Inheritance of Mitochondrial Stress in C. Elegans with a Microfluidic Phenotyping Platform.
Atakan HB, Hof KS, Cornaglia M, Auwerx J, Gijs MAM. Atakan HB, et al. Among authors: auwerx j. Sci Rep. 2019 Dec 17;9(1):19315. doi: 10.1038/s41598-019-55979-x. Sci Rep. 2019. PMID: 31848454 Free PMC article.
Fluctuations and deterioration in environmental conditions potentially have a phenotypic impact that extends over generations. Transgenerational epigenetics is the defined term for such intergenerational transient inheritance without an alteration in the DNA sequence. ...W …
Fluctuations and deterioration in environmental conditions potentially have a phenotypic impact that extends over generations. Transgenerati …
Automated Platform for Long-Term Culture and High-Content Phenotyping of Single C. elegans Worms.
Atakan HB, Xiang R, Cornaglia M, Mouchiroud L, Katsyuba E, Auwerx J, Gijs MAM. Atakan HB, et al. Among authors: auwerx j. Sci Rep. 2019 Oct 4;9(1):14340. doi: 10.1038/s41598-019-50920-8. Sci Rep. 2019. PMID: 31586133 Free PMC article.
Traditionally worms are grown on agar plates, posing many challenges for long-term culture and phenotyping of animals under identical conditions. ...
Traditionally worms are grown on agar plates, posing many challenges for long-term culture and phenotyping of animals under identical …
The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance.
Vannini N, Campos V, Girotra M, Trachsel V, Rojas-Sutterlin S, Tratwal J, Ragusa S, Stefanidis E, Ryu D, Rainer PY, Nikitin G, Giger S, Li TY, Semilietof A, Oggier A, Yersin Y, Tauzin L, Pirinen E, Cheng WC, Ratajczak J, Canto C, Ehrbar M, Sizzano F, Petrova TV, Vanhecke D, Zhang L, Romero P, Nahimana A, Cherix S, Duchosal MA, Ho PC, Deplancke B, Coukos G, Auwerx J, Lutolf MP, Naveiras O. Vannini N, et al. Among authors: auwerx j. Cell Stem Cell. 2019 Mar 7;24(3):405-418.e7. doi: 10.1016/j.stem.2019.02.012. Cell Stem Cell. 2019. PMID: 30849366 Free article.
The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo.
Wan X, Liu L, Zhou P, Hui X, He Q, Yu F, Zhang W, Ding X, Yuan X, Zhang N, Zhao Y, Zhu R, Liu Y, Hao P, Auwerx J, Song X, Leng Q, Zhang Y. Wan X, et al. Among authors: auwerx j. Blood Adv. 2019 Feb 26;3(4):644-657. doi: 10.1182/bloodadvances.2018022756. Blood Adv. 2019. PMID: 30804018 Free PMC article.
Here, we showed that hematopoietic-specific loss of NCoR1 leads to expansion of the hematopoietic stem cell (HSC) pool due to aberrant cell cycle entry of long-term HSCs under steady-state conditions. Moreover, NCoR1-deficient HSCs exhibited normal self-renewal capacity bu …
Here, we showed that hematopoietic-specific loss of NCoR1 leads to expansion of the hematopoietic stem cell (HSC) pool due to aberrant cell …
Reversible and long-term immobilization in a hydrogel-microbead matrix for high-resolution imaging of Caenorhabditis elegans and other small organisms.
Dong L, Cornaglia M, Krishnamani G, Zhang J, Mouchiroud L, Lehnert T, Auwerx J, Gijs MAM. Dong L, et al. Among authors: auwerx j. PLoS One. 2018 Mar 6;13(3):e0193989. doi: 10.1371/journal.pone.0193989. eCollection 2018. PLoS One. 2018. PMID: 29509812 Free PMC article.
We successfully demonstrated the applicability of this method in challenging worm imaging contexts, in particular by applying it for high-resolution confocal imaging of the mitochondrial morphology in worm body wall muscle cells and for the long-term quantification of numb …
We successfully demonstrated the applicability of this method in challenging worm imaging contexts, in particular by applying it for high-re …
Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models.
Cornaglia M, Krishnamani G, Mouchiroud L, Sorrentino V, Lehnert T, Auwerx J, Gijs MA. Cornaglia M, et al. Among authors: auwerx j. Mol Neurodegener. 2016 Feb 9;11:17. doi: 10.1186/s13024-016-0083-6. Mol Neurodegener. 2016. PMID: 26858201 Free PMC article.
We also show the suitability of our system for protein aggregation monitoring in a C. elegans Huntington disease (HD) model, and demonstrate the system's ability to study long-term doxycycline treatment-linked modification of protein aggregation profiles in the ALS model. …
We also show the suitability of our system for protein aggregation monitoring in a C. elegans Huntington disease (HD) model, and demonstrate …
An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging.
Cornaglia M, Mouchiroud L, Marette A, Narasimhan S, Lehnert T, Jovaisaite V, Auwerx J, Gijs MA. Cornaglia M, et al. Among authors: auwerx j. Sci Rep. 2015 May 7;5:10192. doi: 10.1038/srep10192. Sci Rep. 2015. PMID: 25950235 Free PMC article.
Studies of the real-time dynamics of embryonic development require a gentle embryo handling method, the possibility of long-term live imaging during the complete embryogenesis, as well as of parallelization providing a population's statistics, while keeping single embryo r …
Studies of the real-time dynamics of embryonic development require a gentle embryo handling method, the possibility of long-term live …
Dependence of hippocampal function on ERRγ-regulated mitochondrial metabolism.
Pei L, Mu Y, Leblanc M, Alaynick W, Barish GD, Pankratz M, Tseng TW, Kaufman S, Liddle C, Yu RT, Downes M, Pfaff SL, Auwerx J, Gage FH, Evans RM. Pei L, et al. Among authors: auwerx j. Cell Metab. 2015 Apr 7;21(4):628-36. doi: 10.1016/j.cmet.2015.03.004. Cell Metab. 2015. PMID: 25863252 Free PMC article.
ERRgamma(-/-) neurons exhibit decreased metabolic capacity. Impairment of long-term potentiation (LTP) in ERRgamma(-/-) hippocampal slices can be fully rescued by the mitochondrial OxPhos substrate pyruvate, functionally linking the ERRgamma knockout metabolic phenotype an …
ERRgamma(-/-) neurons exhibit decreased metabolic capacity. Impairment of long-term potentiation (LTP) in ERRgamma(-/-) hippocampal s …
17 results