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A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells.
Chen Y, Tristan CA, Chen L, Jovanovic VM, Malley C, Chu PH, Ryu S, Deng T, Ormanoglu P, Tao D, Fang Y, Slamecka J, Hong H, LeClair CA, Michael S, Austin CP, Simeonov A, Singeç I. Chen Y, et al. Among authors: austin cp. Nat Methods. 2021 May;18(5):528-541. doi: 10.1038/s41592-021-01126-2. Epub 2021 May 3. Nat Methods. 2021. PMID: 33941937 Free PMC article.
There is an urgent need to advance strategies that ensure safe and robust long-term growth and functional differentiation of these cells. Here, we deployed high-throughput screening strategies to identify a small-molecule cocktail that improves viability of hPSCs and their …
There is an urgent need to advance strategies that ensure safe and robust long-term growth and functional differentiation of these ce …
Organs-on-chips: into the next decade.
Low LA, Mummery C, Berridge BR, Austin CP, Tagle DA. Low LA, et al. Among authors: austin cp. Nat Rev Drug Discov. 2021 May;20(5):345-361. doi: 10.1038/s41573-020-0079-3. Epub 2020 Sep 10. Nat Rev Drug Discov. 2021. PMID: 32913334 Review.
Therefore, they are likely to become useful additions to traditional preclinical cell culture methods and in vivo animal studies in the near term, and in some cases replacements for them in the longer term. ...
Therefore, they are likely to become useful additions to traditional preclinical cell culture methods and in vivo animal studies in the near …
The National COVID Cohort Collaborative (N3C): Rationale, design, infrastructure, and deployment.
Haendel MA, Chute CG, Bennett TD, Eichmann DA, Guinney J, Kibbe WA, Payne PRO, Pfaff ER, Robinson PN, Saltz JH, Spratt H, Suver C, Wilbanks J, Wilcox AB, Williams AE, Wu C, Blacketer C, Bradford RL, Cimino JJ, Clark M, Colmenares EW, Francis PA, Gabriel D, Graves A, Hemadri R, Hong SS, Hripscak G, Jiao D, Klann JG, Kostka K, Lee AM, Lehmann HP, Lingrey L, Miller RT, Morris M, Murphy SN, Natarajan K, Palchuk MB, Sheikh U, Solbrig H, Visweswaran S, Walden A, Walters KM, Weber GM, Zhang XT, Zhu RL, Amor B, Girvin AT, Manna A, Qureshi N, Kurilla MG, Michael SG, Portilla LM, Rutter JL, Austin CP, Gersing KR; N3C Consortium. Haendel MA, et al. Among authors: austin cp. J Am Med Inform Assoc. 2021 Mar 1;28(3):427-443. doi: 10.1093/jamia/ocaa196. J Am Med Inform Assoc. 2021. PMID: 32805036 Free PMC article.
We expect this effort to save lives by enabling rapid collaboration among clinicians, researchers, and data scientists to identify treatments and specialized care and thereby reduce the immediate and long-term impacts of COVID-19....
We expect this effort to save lives by enabling rapid collaboration among clinicians, researchers, and data scientists to identify treatment …
Translating translation.
Austin CP. Austin CP. Nat Rev Drug Discov. 2018 Jul;17(7):455-456. doi: 10.1038/nrd.2018.27. Epub 2018 Apr 20. Nat Rev Drug Discov. 2018. PMID: 29674698 Free PMC article.
The term 'translation' has emerged as a dominant concept in biomedical science over the last decade, but confusion around what the term means, and how it differs from translational research and translational science, is common. ...
The term 'translation' has emerged as a dominant concept in biomedical science over the last decade, but confusion around what the …
A Cell-based beta-Lactamase Reporter Gene Assay for the CREB Signaling Pathway.
Xia M, Guo V, Huang R, Inglese J, Nirenberg M, Austin CP. Xia M, et al. Among authors: austin cp. Curr Chem Genomics. 2009 Jan 1;3(1):7-12. doi: 10.2174/1875397300903010007. Curr Chem Genomics. 2009. PMID: 19936037 Free PMC article.
CREB-mediated transcription has been implicated in a wide variety of important physiological processes, including long-term memory, and enhancement of CREB signaling has been suggested as an attractive therapeutic strategy for human memory disorders. ...
CREB-mediated transcription has been implicated in a wide variety of important physiological processes, including long-term memory, a …
Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory.
Xia M, Huang R, Guo V, Southall N, Cho MH, Inglese J, Austin CP, Nirenberg M. Xia M, et al. Among authors: austin cp. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2412-7. doi: 10.1073/pnas.0813020106. Epub 2009 Feb 5. Proc Natl Acad Sci U S A. 2009. PMID: 19196967 Free PMC article.
Many studies have implicated the cAMP Response Element Binding (CREB) protein signaling pathway in long-term memory. To identify small molecule enhancers of CREB activation of gene expression, we screened approximately 73,000 compounds, each at 7-15 concentrations in a qua …
Many studies have implicated the cAMP Response Element Binding (CREB) protein signaling pathway in long-term memory. To identify smal …