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Striatonigral direct pathway 2-arachidonoylglycerol contributes to ethanol effects on synaptic transmission and behavior.
Augustin SM, Gracias AL, Luo G, Anumola RC, Lovinger DM. Augustin SM, et al. Neuropsychopharmacology. 2023 Dec;48(13):1941-1951. doi: 10.1038/s41386-023-01671-8. Epub 2023 Aug 1. Neuropsychopharmacology. 2023. PMID: 37528221 Free PMC article.
Endocannabinoids (eCB) and cannabinoid receptor 1 (CB1) play important roles in mediating short- and long-term synaptic plasticity in many brain regions involved in learning and memory, as well as the reinforcing effects of misused substances. ...
Endocannabinoids (eCB) and cannabinoid receptor 1 (CB1) play important roles in mediating short- and long-term synaptic plasticity in …
Chronic Ethanol Consumption Alters Presynaptic Regulation of Dorsal Striatal Dopamine Release in C57BL/6J Mice.
Salinas AG, Nadel JA, Mateo Y, Huynh T, Augustin SM, Pacak K, Lovinger DM. Salinas AG, et al. Among authors: augustin sm. Int J Mol Sci. 2022 Sep 20;23(19):10994. doi: 10.3390/ijms231910994. Int J Mol Sci. 2022. PMID: 36232321 Free PMC article.
Dopamine has been implicated in neural and behavioral processes involved in reward and reinforcement and is a critical neurotransmitter in AUD. Clinical and preclinical research has shown that long-term ethanol exposure can alter dopamine release, though most of this work …
Dopamine has been implicated in neural and behavioral processes involved in reward and reinforcement and is a critical neurotransmitter in A …
Synaptic changes induced by cannabinoid drugs and cannabis use disorder.
Augustin SM, Lovinger DM. Augustin SM, et al. Neurobiol Dis. 2022 Jun 1;167:105670. doi: 10.1016/j.nbd.2022.105670. Epub 2022 Feb 24. Neurobiol Dis. 2022. PMID: 35219856 Free article. Review.
Like many drugs of abuse, cannabis and cannabis-derived drugs are prone to misuse, and long-term usage can lead to drug tolerance and the development of Cannabis Use Disorder (CUD). ...
Like many drugs of abuse, cannabis and cannabis-derived drugs are prone to misuse, and long-term usage can lead to drug tolerance and …
Decompensation in Advanced Nonalcoholic Fatty Liver Disease May Occur at Lower Hepatic Venous Pressure Gradient Levels Than in Patients With Viral Disease.
Bassegoda O, Olivas P, Turco L, Mandorfer M, Serra-Burriel M, Tellez L, Kwanten W, Laroyenne A, Farcau O, Alvarado E, Moga L, Vuille-Lessard E, Fortea JI, Ibañez L, Tosetti G, Vanwolleghem T, Larrue H, Burgos-Santamaría D, Stefanescu H, Paternostro R, Cippitelli A, Lens S, Augustin S, Llop E, Laleman W, Trebicka J, Chang J, Masnou H, Zipprich A, Miceli F, Semmler G, Forns X, Primignani M, Bañares R, Puente A, Berzigotti A, Rautou PE, Villanueva C, Ginès P, Garcia-Pagan JC, Procopet B, Bureau C, Albillos A, Francque S, Reiberger T, Schepis F, Graupera I, Hernandez-Gea V. Bassegoda O, et al. Among authors: augustin s. Clin Gastroenterol Hepatol. 2022 Oct;20(10):2276-2286.e6. doi: 10.1016/j.cgh.2021.10.023. Epub 2021 Oct 21. Clin Gastroenterol Hepatol. 2022. PMID: 34688952 Free article.
Longitudinal studies aiming to identify HVPG thresholds able to predict decompensation and long-term outcomes in aNAFLD population are strongly needed....
Longitudinal studies aiming to identify HVPG thresholds able to predict decompensation and long-term outcomes in aNAFLD population ar …
Steatosis as main determinant of portal hypertension through a restriction of hepatic sinusoidal area in a dietary rat nash model.
Barberá A, Raurell I, García-Lezana T, Torres-Arauz M, Bravo M, Hide D, Gil M, Salcedo MT, Genescà J, Martell M, Augustin S. Barberá A, et al. Among authors: augustin s. Liver Int. 2020 Nov;40(11):2732-2743. doi: 10.1111/liv.14632. Epub 2020 Oct 13. Liver Int. 2020. PMID: 32770818
Liver endothelial dysfunction (ED) has been shown as responsible for this effect in short-term dietary animal models. We evaluated the persistence of PH and underlying mechanisms in a long-term rat model of NASH. ...CONCLUSION: Liver steatosis per se (in absence of …
Liver endothelial dysfunction (ED) has been shown as responsible for this effect in short-term dietary animal models. We evaluated th …
Soil solution in Swiss forest stands: A 20 year's time series.
Braun S, Tresch S, Augustin S. Braun S, et al. Among authors: augustin s. PLoS One. 2020 Jul 14;15(7):e0227530. doi: 10.1371/journal.pone.0227530. eCollection 2020. PLoS One. 2020. PMID: 32663212 Free PMC article.
The forest sites comprise two major forest types of Switzerland including a wide range of ecological gradients such as different nitrogen (N) deposition and soil conditions. The long-term data set of 20 years of soil solution measurements revealed an ongoing, but site-spec …
The forest sites comprise two major forest types of Switzerland including a wide range of ecological gradients such as different nitrogen (N …
β blockers to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension (PREDESCI): a randomised, double-blind, placebo-controlled, multicentre trial.
Villanueva C, Albillos A, Genescà J, Garcia-Pagan JC, Calleja JL, Aracil C, Bañares R, Morillas RM, Poca M, Peñas B, Augustin S, Abraldes JG, Alvarado E, Torres F, Bosch J. Villanueva C, et al. Among authors: augustin s. Lancet. 2019 Apr 20;393(10181):1597-1608. doi: 10.1016/S0140-6736(18)31875-0. Epub 2019 Mar 22. Lancet. 2019. PMID: 30910320 Clinical Trial.
Six patients (four in the beta blockers group) had severe adverse events. INTERPRETATION: Long-term treatment with beta blockers could increase decompensation-free survival in patients with compensated cirrhosis and CSPH, mainly by reducing the incidence of ascites. ...
Six patients (four in the beta blockers group) had severe adverse events. INTERPRETATION: Long-term treatment with beta blockers coul …
Active Zone Proteins RIM1αβ Are Required for Normal Corticostriatal Transmission and Action Control.
Kupferschmidt DA, Augustin SM, Johnson KA, Lovinger DM. Kupferschmidt DA, et al. Among authors: augustin sm. J Neurosci. 2019 Feb 20;39(8):1457-1470. doi: 10.1523/JNEUROSCI.1940-18.2018. Epub 2018 Dec 17. J Neurosci. 2019. PMID: 30559150 Free PMC article.
Key forms of presynaptic G-protein-coupled receptor-mediated short- and long-term striatal plasticity are spared following RIM1 deletion. Conditional RIM1 KO mice show heightened novelty-induced locomotion and impaired motor learning on the accelerating rotarod. ...
Key forms of presynaptic G-protein-coupled receptor-mediated short- and long-term striatal plasticity are spared following RIM1 delet …
Dual Dopaminergic Regulation of Corticostriatal Plasticity by Cholinergic Interneurons and Indirect Pathway Medium Spiny Neurons.
Augustin SM, Chancey JH, Lovinger DM. Augustin SM, et al. Cell Rep. 2018 Sep 11;24(11):2883-2893. doi: 10.1016/j.celrep.2018.08.042. Cell Rep. 2018. PMID: 30208314 Free PMC article.
Endocannabinoid (eCB)-mediated long-term depression (LTD) requires dopamine (DA) D2 receptors (D2Rs) for eCB mobilization. ...
Endocannabinoid (eCB)-mediated long-term depression (LTD) requires dopamine (DA) D2 receptors (D2Rs) for eCB mobilization. ...
Chronic exposure to tumor necrosis factor alpha induces retinal pigment epithelium cell dedifferentiation.
Touhami S, Beguier F, Augustin S, Charles-Messance H, Vignaud L, Nandrot EF, Reichman S, Forster V, Mathis T, Sahel JA, Bodaghi B, Guillonneau X, Sennlaub F. Touhami S, et al. Among authors: augustin s. J Neuroinflammation. 2018 Mar 16;15(1):85. doi: 10.1186/s12974-018-1106-8. J Neuroinflammation. 2018. PMID: 29548329 Free PMC article.
We have previously shown that acute stimulation of RPE cells by tumor necrosis factor alpha (TNFalpha) downregulates the expression of OTX2 (Orthodenticle homeobox 2) and dependent RPE genes. We here investigated the long-term effects of TNFalpha on RPE cell morphology and …
We have previously shown that acute stimulation of RPE cells by tumor necrosis factor alpha (TNFalpha) downregulates the expression of OTX2 …
21 results