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Abatacept and non-melanoma skin cancer in patients with rheumatoid arthritis: a comprehensive evaluation of randomised controlled trials and observational studies.
Simon TA, Dong L, Suissa S, Michaud K, Pedro S, Hochberg M, Boers M, Askling J, Frisell T, Strangfeld A, Meissner Y, Khaychuk V, Dominique A, Maldonado MA. Simon TA, et al. Among authors: askling j. Ann Rheum Dis. 2024 Jan 11;83(2):177-183. doi: 10.1136/ard-2023-224356. Ann Rheum Dis. 2024. PMID: 37932010 Free PMC article. Review.
In randomised trials (n=4138; median abatacept exposure, 12 (range 2-30) months), NMSC IRs (95% CIs) were not significantly different for abatacept (6.0 (3.3 to 10.0)) and placebo (4.0 (1.3 to 9.3)) and remained stable throughout the long-term, open-label period (median cu …
In randomised trials (n=4138; median abatacept exposure, 12 (range 2-30) months), NMSC IRs (95% CIs) were not significantly different for ab …
How does current disease activity in rheumatoid arthritis affect the short-term risk of acute coronary syndrome? A clinical register based study from Sweden and Norway.
Delcoigne B, Provan SA, Kristianslund EK, Askling J, Ljung L. Delcoigne B, et al. Among authors: askling j. Eur J Intern Med. 2023 Sep;115:55-61. doi: 10.1016/j.ejim.2023.06.013. Epub 2023 Jun 22. Eur J Intern Med. 2023. PMID: 37355347 Free article.
OBJECTIVES: To estimate short-term risks of acute coronary syndrome (ACS) in patients with rheumatoid arthritis (RA) as a function of current RA disease activity including remission. ...CONCLUSION: Failure to reach remission is associated with elevated short-term ri …
OBJECTIVES: To estimate short-term risks of acute coronary syndrome (ACS) in patients with rheumatoid arthritis (RA) as a function of …
Genome-wide investigation of persistence with methotrexate treatment in early rheumatoid arthritis.
Sysojev AÖ, Saevarsdottir S, Diaz-Gallo LM, Silberberg GN, Alfredsson L, Klareskog L, Baecklund E, Björkman L, Kastbom A, Rantapää-Dahlqvist S, Turesson C, Jonsdottir I, Stefansson K, Frisell T, Padyukov L, Askling J, Westerlind H. Sysojev AÖ, et al. Among authors: askling j. Rheumatology (Oxford). 2024 May 2;63(5):1221-1229. doi: 10.1093/rheumatology/kead301. Rheumatology (Oxford). 2024. PMID: 37326842 Free PMC article.
METHODS: We conducted a genome-wide association study (GWAS) in a sample of 3902 Swedish early-RA patients initiating MTX in DMARD monotherapy as their first-ever DMARD. The outcome, short- and long-term MTX treatment persistence, was defined as remaining on MTX at 1 and a …
METHODS: We conducted a genome-wide association study (GWAS) in a sample of 3902 Swedish early-RA patients initiating MTX in DMARD monothera …
Cancer risks with JAKi and biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis or psoriatic arthritis: a national real-world cohort study.
Huss V, Bower H, Hellgren K, Frisell T, Askling J; Behalf of the ARTIS group; behalf of the ARTIS group. Huss V, et al. Among authors: askling j. Ann Rheum Dis. 2023 Jul;82(7):911-919. doi: 10.1136/ard-2022-223636. Epub 2023 Mar 3. Ann Rheum Dis. 2023. PMID: 36868796 Free PMC article.
In PsA, based on 5 vs 73 incident cancers other than NMSC, and 8 vs 73 incident NMSC, the corresponding HRs were 1.9 (95% CI 0.7 to 5.2) and 2.1 (95% CI 0.8 to 5.3). CONCLUSION: In clinical practice, the short-term risk of cancer other than NMSC in individuals initiating t …
In PsA, based on 5 vs 73 incident cancers other than NMSC, and 8 vs 73 incident NMSC, the corresponding HRs were 1.9 (95% CI 0.7 to 5.2) and …
Does persistence to methotrexate treatment in early rheumatoid arthritis have a familial component?
Sysojev AÖ, Frisell T, Delcoigne B, Saevarsdottir S, Askling J, Westerlind H. Sysojev AÖ, et al. Among authors: askling j. Arthritis Res Ther. 2022 Aug 6;24(1):185. doi: 10.1186/s13075-022-02873-z. Arthritis Res Ther. 2022. PMID: 35933427 Free PMC article.
METHODS: First-degree relative pairs diagnosed with RA 1999-2018 and starting MTX (in monotherapy) as their first disease-modifying anti-rheumatic drug (DMARD) treatment were identified by linking the Swedish Rheumatology Quality Register to national registers. Short- and long- …
METHODS: First-degree relative pairs diagnosed with RA 1999-2018 and starting MTX (in monotherapy) as their first disease-modifying anti-rhe …
Short-term, intermediate-term and long-term risks of acute coronary syndrome in cohorts of patients with RA starting biologic DMARDs: results from four Nordic countries.
Delcoigne B, Ljung L, Provan SA, Glintborg B, Hetland ML, Grøn KL, Peltomaa R, Relas H, Turesson C, Gudbjornsson B, Michelsen B, Askling J. Delcoigne B, et al. Among authors: askling j. Ann Rheum Dis. 2022 Jun;81(6):789-797. doi: 10.1136/annrheumdis-2021-221996. Epub 2022 Mar 22. Ann Rheum Dis. 2022. PMID: 35318218 Free PMC article.
CONCLUSION: The rate of ACS among patients with RA initiating bDMARDs remains elevated compared with the general population. As used in routine care, the short-term, intermediate-term and longer-term risks of ACS vary little across individual bDMARDs....
CONCLUSION: The rate of ACS among patients with RA initiating bDMARDs remains elevated compared with the general population. As used in rout …
Short- and longer-term cancer risks with biologic and targeted synthetic disease-modifying antirheumatic drugs as used against rheumatoid arthritis in clinical practice.
Huss V, Bower H, Wadström H, Frisell T, Askling J; ARTIS group. Huss V, et al. Among authors: askling j. Rheumatology (Oxford). 2022 May 5;61(5):1810-1818. doi: 10.1093/rheumatology/keab570. Rheumatology (Oxford). 2022. PMID: 34324640 Free PMC article.
For other b/tsDMARDs, we noted no consistent signal of increased overall risks (HRs ranged from 1.0 to 1.2), but there were statistically significant estimates above 1 for abatacept with 2-5 years of active treatment, for older age groups, and between several of the bDMARDs and u …
For other b/tsDMARDs, we noted no consistent signal of increased overall risks (HRs ranged from 1.0 to 1.2), but there were statistically si …
Morbidity, risk of cancer and mortality in 3645 HFE mutations carriers.
Hagström H, Ndegwa N, Jalmeus M, Ekstedt M, Posserud I, Rorsman F, Nyhlin N, Klintman D, Werner M, Marschall HU, Askling J, Stål P; Swedish Hepatology Study Group (SweHep). Hagström H, et al. Among authors: askling j. Liver Int. 2021 Mar;41(3):545-553. doi: 10.1111/liv.14792. Epub 2021 Jan 26. Liver Int. 2021. PMID: 33450138 Free article.
BACKGROUND & AIMS: Mutations in the HFE gene can lead to hereditary haemochromatosis (HH) and have been suggested to increase the risk of extra-hepatic diseases, especially breast and colorectal cancer. Here we investigated long-term outcomes of Swedish patients with H …
BACKGROUND & AIMS: Mutations in the HFE gene can lead to hereditary haemochromatosis (HH) and have been suggested to increase the risk o …
Pancreatic Cancer Following Acute Pancreatitis: A Population-based Matched Cohort Study.
Sadr-Azodi O, Oskarsson V, Discacciati A, Videhult P, Askling J, Ekbom A. Sadr-Azodi O, et al. Among authors: askling j. Am J Gastroenterol. 2018 Nov;113(11):1711-1719. doi: 10.1038/s41395-018-0255-9. Epub 2018 Oct 12. Am J Gastroenterol. 2018. PMID: 30315287
Any association between non-gallstone-related acute pancreatitis and pancreatic cancer in the long-term (>10 years) could be mediated through recurrent acute pancreatitis or chronic pancreatitis....
Any association between non-gallstone-related acute pancreatitis and pancreatic cancer in the long-term (>10 years) could be media …
32 results