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A population-based cohort study of late mortality in adult autologous hematopoietic stem cell transplant recipients in Australia.
Ashton LJ, Le Marsney RE, Dodds AJ, Nivison-Smith I, Wilcox L, O'Brien TA, Vajdic CM. Ashton LJ, et al. Biol Blood Marrow Transplant. 2014 Jul;20(7):937-45. doi: 10.1016/j.bbmt.2014.03.006. Epub 2014 Mar 13. Biol Blood Marrow Transplant. 2014. PMID: 24631736 Free article.
Our findings show that prevention of disease recurrence remains 1 of the greatest challenges for autologous HSCT recipients, while the increasing rates of nonrelapse deaths due to the emergence of second cancers, circulatory diseases, and respiratory diseases highlight the long- …
Our findings show that prevention of disease recurrence remains 1 of the greatest challenges for autologous HSCT recipients, while the incre …
Effector HIV-specific cytotoxic T-lymphocyte activity in long-term nonprogressors: associations with viral replication and progression.
Keoshkerian E, Ashton LJ, Smith DG, Ziegler JB, Kaldor JM, Cooper DA, Stewart GJ, Ffrench RA. Keoshkerian E, et al. Among authors: ashton lj. J Med Virol. 2003 Dec;71(4):483-91. doi: 10.1002/jmv.10525. J Med Virol. 2003. PMID: 14556259
Ex vivo effector cytotoxic T-lymphocyte (CTL) activity was assessed in 27 members of the Australian Long-Term Nonprogressor cohort and correlated with genetic, virological, and immunological markers. ...These findings demonstrate the importance of HIV replication in genera …
Ex vivo effector cytotoxic T-lymphocyte (CTL) activity was assessed in 27 members of the Australian Long-Term Nonprogressor cohort an …
HLA and other host factors in transfusion-acquired HIV-1 infection.
Geczy AF, Kuipers H, Coolen M, Ashton LJ, Kennedy C, Ng G, Dodd R, Wallace R, Le T, Raynes-Greenow CH, Dyer WB, Learmont JC, Sullivan JS. Geczy AF, et al. Among authors: ashton lj. Hum Immunol. 2000 Feb;61(2):172-6. doi: 10.1016/s0198-8859(99)00142-1. Hum Immunol. 2000. PMID: 10717811
Host factors that may contribute to disease progression include HLA and allelic variants of the chemokine receptors CCR5 and CCR2, which have been shown to influence both long-term survival and rapid progression. In this study, we have examined the contribution of HLA and …
Host factors that may contribute to disease progression include HLA and allelic variants of the chemokine receptors CCR5 and CCR2, which hav …
CCR5 promoter polymorphisms, CCR5 59029A and CCR5 59353C, are under represented in HIV-1-infected long-term non-progressors. The Australian Long-Term Non-Progressor Study Group.
Clegg AO, Ashton LJ, Biti RA, Badhwar P, Williamson P, Kaldor JM, Stewart GJ. Clegg AO, et al. Among authors: ashton lj. AIDS. 2000 Jan 28;14(2):103-8. doi: 10.1097/00002030-200001280-00004. AIDS. 2000. PMID: 10708279
CCR5 59029A and CCR5 59353C homozygotes were found to be significantly under-represented in the long-term non-progressor group as compared with the other HIV-1-positive groups, with the effect being more marked in the absence of the CCR5 delta32 and CCR2 64I mutations. CON …
CCR5 59029A and CCR5 59353C homozygotes were found to be significantly under-represented in the long-term non-progressor group as com …
Effect of long-term infection with nef-defective attenuated HIV type 1 on CD4+ and CD8+ T lymphocytes: increased CD45RO+CD4+ T lymphocytes and limited activation of CD8+ T lymphocytes.
Zaunders JJ, Geczy AF, Dyer WB, McIntyre LB, Cooley MA, Ashton LJ, Raynes-Greenow CH, Learmont J, Cooper DA, Sullivan JS. Zaunders JJ, et al. Among authors: ashton lj. AIDS Res Hum Retroviruses. 1999 Nov 20;15(17):1519-27. doi: 10.1089/088922299309801. AIDS Res Hum Retroviruses. 1999. PMID: 10580402
In particular, SBBC members with undetectable plasma HIV-1 RNA had normal levels of activated CD8+ T lymphocytes. Therefore, the result of long-term infection with natural nef/LTR mutant HIV-1 in these subjects suggests a decreased cytopathic effect of attenuated HIV-1 on …
In particular, SBBC members with undetectable plasma HIV-1 RNA had normal levels of activated CD8+ T lymphocytes. Therefore, the result of l …
Predictors of progression in long-term nonprogressors. Australian Long-Term Nonprogressor Study Group.
Ashton LJ, Carr A, Cunningham PH, Roggensack M, McLean K, Law M, Robertson M, Cooper DA, Kaldor JM. Ashton LJ, et al. AIDS Res Hum Retroviruses. 1998 Jan 20;14(2):117-21. doi: 10.1089/aid.1998.14.117. AIDS Res Hum Retroviruses. 1998. PMID: 9462921
We determined the virological and immunological characteristics of a cohort of long-term nonprogressors in Australia and examined the role of these factors in predicting disease progression. ...These findings show that the serum concentration of beta2-microglobulin is a st …
We determined the virological and immunological characteristics of a cohort of long-term nonprogressors in Australia and examined the …
Increased frequency of CCR-5 delta 32 heterozygotes among long-term non-progressors with HIV-1 infection. The Australian Long-Term Non-Progressor Study Group.
Stewart GJ, Ashton LJ, Biti RA, Ffrench RA, Bennetts BH, Newcombe NR, Benson EM, Carr A, Cooper DA, Kaldor JM. Stewart GJ, et al. Among authors: ashton lj. AIDS. 1997 Dec;11(15):1833-8. doi: 10.1097/00002030-199715000-00007. AIDS. 1997. PMID: 9412701
OBJECTIVE: To determine the effect of a common 32 base-pair deletion mutation in the CCR-5 gene (CCR-5 delta 32) on progression of HIV infection to AIDS, and to assess the level of heterozygosity for this mutation in a well-defined group of long-term non-progressors (LTNP) …
OBJECTIVE: To determine the effect of a common 32 base-pair deletion mutation in the CCR-5 gene (CCR-5 delta 32) on progression of HIV infec …