High-dimensional phenotyping to define the genetic basis of cellular morphology.
Tegtmeyer M, Arora J, Asgari S, Cimini BA, Nadig A, Peirent E, Liyanage D, Way GP, Weisbart E, Nathan A, Amariuta T, Eggan K, Haghighi M, McCarroll SA, O'Connor L, Carpenter AE, Singh S, Nehme R, Raychaudhuri S.
Tegtmeyer M, et al. Among authors: arora j.
Nat Commun. 2024 Jan 6;15(1):347. doi: 10.1038/s41467-023-44045-w.
Nat Commun. 2024.
PMID: 38184653
Free PMC article.
Here, we combine genomic sequencing and high-content imaging approaches on iPSCs from 297 unique donors to investigate the relationship between genetic variants and cellular morphology to map what we term cell morphological quantitative trait loci (cmQTLs). We identify nov …
Here, we combine genomic sequencing and high-content imaging approaches on iPSCs from 297 unique donors to investigate the relationship betw …