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Deficiency of rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress, and reduces myocardial remodeling in a mouse model of type 1 diabetes.
Li J, Zhu H, Shen E, Wan L, Arnold JM, Peng T. Li J, et al. Among authors: arnold jm. Diabetes. 2010 Aug;59(8):2033-42. doi: 10.2337/db09-1800. Epub 2010 Jun 3. Diabetes. 2010. PMID: 20522592 Free PMC article.
OBJECTIVE: Our recent study demonstrated that Rac1 and NADPH oxidase activation contributes to cardiomyocyte apoptosis in short-term diabetes. This study was undertaken to investigate if disruption of Rac1 and inhibition of NADPH oxidase would prevent myocardial remodeling …
OBJECTIVE: Our recent study demonstrated that Rac1 and NADPH oxidase activation contributes to cardiomyocyte apoptosis in short-term …
The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy.
Hackam DG, Khan NA, Hemmelgarn BR, Rabkin SW, Touyz RM, Campbell NR, Padwal R, Campbell TS, Lindsay MP, Hill MD, Quinn RR, Mahon JL, Herman RJ, Schiffrin EL, Ruzicka M, Larochelle P, Feldman RD, Lebel M, Poirier L, Arnold JM, Moe GW, Howlett JG, Trudeau L, Bacon SL, Petrella RJ, Milot A, Stone JA, Drouin D, Boulanger JM, Sharma M, Hamet P, Fodor G, Dresser GK, Carruthers SG, Pylypchuk G, Burgess ED, Burns KD, Vallée M, Prasad GV, Gilbert RE, Leiter LA, Jones C, Ogilvie RI, Woo V, McFarlane PA, Hegele RA, Tobe SW; Canadian Hypertension Education Program. Hackam DG, et al. Among authors: arnold jm. Can J Cardiol. 2010 May;26(5):249-58. doi: 10.1016/s0828-282x(10)70379-2. Can J Cardiol. 2010. PMID: 20485689 Free PMC article. Review.
However, for lifestyle interventions, blood pressure lowering was accepted as a primary outcome given the general lack of long-term morbidity and mortality data in this field. Progressive renal impairment was also accepted as a clinically relevant primary outcome among pat …
However, for lifestyle interventions, blood pressure lowering was accepted as a primary outcome given the general lack of long-term m …
Left atrial remodelling in patients with myocardial infarction complicated by heart failure, left ventricular dysfunction, or both: the VALIANT Echo study.
Meris A, Amigoni M, Uno H, Thune JJ, Verma A, Køber L, Bourgoun M, McMurray JJ, Velazquez EJ, Maggioni AP, Ghali J, Arnold JM, Zelenkofske S, Pfeffer MA, Solomon SD. Meris A, et al. Among authors: arnold jm. Eur Heart J. 2009 Jan;30(1):56-65. doi: 10.1093/eurheartj/ehn499. Epub 2008 Nov 11. Eur Heart J. 2009. PMID: 19001474
AIMS: To assess the relationship between left atrial (LA) size and outcome after high-risk myocardial infarction (MI) and to study dynamic changes in LA size during long-term follow-up. METHODS AND RESULTS: The VALIANT Echocardiography study prospectively enrolled 610 pati …
AIMS: To assess the relationship between left atrial (LA) size and outcome after high-risk myocardial infarction (MI) and to study dynamic c …
Long-term trandolapril treatment is associated with reduced aortic stiffness: the prevention of events with angiotensin-converting enzyme inhibition hemodynamic substudy.
Mitchell GF, Dunlap ME, Warnica W, Ducharme A, Arnold JM, Tardif JC, Solomon SD, Domanski MJ, Jablonski KA, Rice MM, Pfeffer MA; Prevention of Events With Angiotensin-Converting Enzyme Inhibition Investigators. Mitchell GF, et al. Among authors: arnold jm. Hypertension. 2007 Jun;49(6):1271-7. doi: 10.1161/HYPERTENSIONAHA.106.085738. Epub 2007 Apr 23. Hypertension. 2007. PMID: 17452505 Free PMC article. Clinical Trial.
Albatross populations in peril: a population trajectory for black-browed albatrosses at south Georgia.
Arnold JM, Brault S, Croxall JP. Arnold JM, et al. Ecol Appl. 2006 Feb;16(1):419-32. doi: 10.1890/03-5340. Ecol Appl. 2006. PMID: 16705990
The temporal shift in annual values coincided with the start of longline fishing at South Georgia and potential changes in krill abundance. We used 23 years of demographic data from long-term studies of a breeding colony of this species at Bird Island, South Georgia, to va …
The temporal shift in annual values coincided with the start of longline fishing at South Georgia and potential changes in krill abundance. …
Rationale, design and baseline characteristics of a large, simple, randomized trial of combined folic acid and vitamins B6 and B12 in high-risk patients: the Heart Outcomes Prevention Evaluation (HOPE)-2 trial.
Lonn E, Held C, Arnold JM, Probstfield J, McQueen M, Micks M, Pogue J, Sheridan P, Bosch J, Genest J, Yusuf S; HOPE-2 Investigators. Lonn E, et al. Among authors: arnold jm. Can J Cardiol. 2006 Jan;22(1):47-53. doi: 10.1016/s0828-282x(06)70238-0. Can J Cardiol. 2006. PMID: 16450017 Free PMC article. Clinical Trial.
Therefore, a large, randomized clinical trial--the Heart Outcomes Prevention Evaluation (HOPE)-2 study--is being conducted to evaluate this therapy in patients at high risk for CV events. OBJECTIVES: To evaluate whether long-term therapy with folic acid and vitamins B6 and …
Therefore, a large, randomized clinical trial--the Heart Outcomes Prevention Evaluation (HOPE)-2 study--is being conducted to evaluate this …
Pilot study to determine the impact of a multidisciplinary educational intervention in patients hospitalized with heart failure.
Gwadry-Sridhar FH, Arnold JM, Zhang Y, Brown JE, Marchiori G, Guyatt G. Gwadry-Sridhar FH, et al. Among authors: arnold jm. Am Heart J. 2005 Nov;150(5):982. doi: 10.1016/j.ahj.2005.08.016. Am Heart J. 2005. PMID: 16290975 Clinical Trial.
PATIENTS: One hundred thirty four patients with a clinical diagnosis of HF and a left ventricular ejection fraction of < 40% requiring long-term medical treatment. MAIN OUTCOME MEASURES: A validated HF-specific instrument provided a measure of knowledge. ...

PATIENTS: One hundred thirty four patients with a clinical diagnosis of HF and a left ventricular ejection fraction of < 40% requiring lo

…
Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial.
Lonn E, Bosch J, Yusuf S, Sheridan P, Pogue J, Arnold JM, Ross C, Arnold A, Sleight P, Probstfield J, Dagenais GR; HOPE and HOPE-TOO Trial Investigators. Lonn E, et al. Among authors: arnold jm. JAMA. 2005 Mar 16;293(11):1338-47. doi: 10.1001/jama.293.11.1338. JAMA. 2005. PMID: 15769967 Clinical Trial.
Clinical trials have generally failed to confirm benefits, possibly due to their relatively short duration. OBJECTIVE: To evaluate whether long-term supplementation with vitamin E decreases the risk of cancer, cancer death, and major cardiovascular events. ...CONCLUSION: I …
Clinical trials have generally failed to confirm benefits, possibly due to their relatively short duration. OBJECTIVE: To evaluate whether l …
Predictors of late development of heart failure in stable survivors of myocardial infarction: the CARE study.
Lewis EF, Moye LA, Rouleau JL, Sacks FM, Arnold JM, Warnica JW, Flaker GC, Braunwald E, Pfeffer MA; CARE Study. Lewis EF, et al. Among authors: arnold jm. J Am Coll Cardiol. 2003 Oct 15;42(8):1446-53. doi: 10.1016/s0735-1097(03)01057-x. J Am Coll Cardiol. 2003. PMID: 14563590 Free article.
OBJECTIVES: We sought to determine the predictors of heart failure (HF) development in long-term survivors of myocardial infarction (MI). BACKGROUND: Modern strategies of acute MI care have resulted in an increasing proportion of survivors at heightened risk of future non- …
OBJECTIVES: We sought to determine the predictors of heart failure (HF) development in long-term survivors of myocardial infarction ( …
19 results