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Sustained expression from DNA vectors.
Wong SP, Argyros O, Harbottle RP. Wong SP, et al. Among authors: argyros o. Adv Genet. 2015;89:113-152. doi: 10.1016/bs.adgen.2014.11.002. Epub 2014 Dec 18. Adv Genet. 2015. PMID: 25620010 Review.
Genetic modification of cancer cells using non-viral, episomal S/MAR vectors for in vivo tumour modelling.
Argyros O, Wong SP, Gowers K, Harbottle RP. Argyros O, et al. PLoS One. 2012;7(10):e47920. doi: 10.1371/journal.pone.0047920. Epub 2012 Oct 26. PLoS One. 2012. PMID: 23110132 Free PMC article.
Recently, we have generated an episomally maintained plasmid DNA (pDNA) expression system based on Scaffold/Matrix Attachment Region (S/MAR), which permits long-term luciferase transgene expression in the mouse liver. Here we describe a further usage of this pDNA vector wi …
Recently, we have generated an episomally maintained plasmid DNA (pDNA) expression system based on Scaffold/Matrix Attachment Region (S/MAR) …
Systemic gene transfer of polyethylenimine (PEI)-plasmid DNA complexes to neonatal mice.
Wong SP, Argyros O, Howe SJ, Harbottle RP. Wong SP, et al. Among authors: argyros o. J Control Release. 2011 Mar 30;150(3):298-306. doi: 10.1016/j.jconrel.2010.12.010. Epub 2010 Dec 28. J Control Release. 2011. PMID: 21192993
We also investigate the specific targeting of transgene expression to the proliferating neonate liver using a liver-specific plasmid containing a Scaffold Matrix Attachment Region (S/MAR) element, which has previously been shown to confer long-term expression in adult mous …
We also investigate the specific targeting of transgene expression to the proliferating neonate liver using a liver-specific plasmid contain …
pEPito: a significantly improved non-viral episomal expression vector for mammalian cells.
Haase R, Argyros O, Wong SP, Harbottle RP, Lipps HJ, Ogris M, Magnusson T, Vizoso Pinto MG, Haas J, Baiker A. Haase R, et al. Among authors: argyros o. BMC Biotechnol. 2010 Mar 15;10:20. doi: 10.1186/1472-6750-10-20. BMC Biotechnol. 2010. PMID: 20230618 Free PMC article.
The original pEPI-1 vector contains two mammalian transcription units and a total of 305 CpG islands, which are located predominantly within the vector elements necessary for bacterial propagation and known to be counterproductive for persistent long-term transgene express …
The original pEPI-1 vector contains two mammalian transcription units and a total of 305 CpG islands, which are located predominantly within …
Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector.
Argyros O, Wong SP, Niceta M, Waddington SN, Howe SJ, Coutelle C, Miller AD, Harbottle RP. Argyros O, et al. Gene Ther. 2008 Dec;15(24):1593-605. doi: 10.1038/gt.2008.113. Epub 2008 Jul 17. Gene Ther. 2008. PMID: 18633447
Long-term expression is demonstrated by monitoring the longitudinal luciferase expression profile for up to 6 months by means of in situ bioluminescent imaging. ...We conclude that the combination of a mammalian, tissue-specific promoter with the S/MAR element is sufficien …
Long-term expression is demonstrated by monitoring the longitudinal luciferase expression profile for up to 6 months by means of in s …