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Pitolisant-supported bridging during drug holidays to deal with tolerance to modafinil in patients with narcolepsy.
Winter Y, Lang C, Kallweit U, Apel D, Fleischer V, Ellwardt E, Groppa S. Winter Y, et al. Among authors: apel d. Sleep Med. 2023 Dec;112:116-121. doi: 10.1016/j.sleep.2023.10.005. Epub 2023 Oct 9. Sleep Med. 2023. PMID: 37839272 Free article.
STUDY OBJECTIVES: Modafinil is a common treatment for excessive daytime sleepiness (EDS) in narcolepsy. The long-term use of modafinil can lead to tolerance with the loss of efficacy and the continuous increase of its dose. ...
STUDY OBJECTIVES: Modafinil is a common treatment for excessive daytime sleepiness (EDS) in narcolepsy. The long-term use of modafini …
Follow-up after endoscopic snare resection of duodenal adenomas.
Apel D, Jakobs R, Spiethoff A, Riemann JF. Apel D, et al. Endoscopy. 2005 May;37(5):444-8. doi: 10.1055/s-2005-861287. Endoscopy. 2005. PMID: 15844023
Recurrence after local excision is reported to be frequent, so many authors propose radical surgical treatment of these tumors. The aim of this study was to determine the long-term outcome after endoscopic resection of duodenal adenomas. PATIENTS AND METHODS: Between Janua …
Recurrence after local excision is reported to be frequent, so many authors propose radical surgical treatment of these tumors. The aim of t …
Photodynamic therapy for palliation of nonresectable bile duct cancer--preliminary results with a new diode laser system.
Zoepf T, Jakobs R, Arnold JC, Apel D, Rosenbaum A, Riemann JF. Zoepf T, et al. Among authors: apel d. Am J Gastroenterol. 2001 Jul;96(7):2093-7. doi: 10.1111/j.1572-0241.2001.03968.x. Am J Gastroenterol. 2001. PMID: 11467637 Clinical Trial.
Randomized, controlled studies comparing PDT with the insertion of endoprostheses and long term follow-up of results are needed to confirm the promising short term results....
Randomized, controlled studies comparing PDT with the insertion of endoprostheses and long term follow-up of results are needed to co …