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Long-term safety and efficacy of tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study.
Flume PA, Biner RF, Downey DG, Brown C, Jain M, Fischer R, De Boeck K, Sawicki GS, Chang P, Paz-Diaz H, Rubin JL, Yang Y, Hu X, Pasta DJ, Millar SJ, Campbell D, Wang X, Ahluwalia N, Owen CA, Wainwright CE; VX14-661-110 study group. Flume PA, et al. Lancet Respir Med. 2021 Jul;9(7):733-746. doi: 10.1016/S2213-2600(20)30510-5. Epub 2021 Feb 10. Lancet Respir Med. 2021. PMID: 33581080
Here, we present results of study 661-110 (EXTEND), a 96-week open-label extension study that assessed long-term safety, tolerability, and efficacy of tezacaftor-ivacaftor in participants aged 12 years or older with cystic fibrosis who were homozygous or heterozygous for t …
Here, we present results of study 661-110 (EXTEND), a 96-week open-label extension study that assessed long-term safety, tolerability …
Association of socioeconomic status with the use of chronic therapies and healthcare utilization in children with cystic fibrosis.
Schechter MS, McColley SA, Silva S, Haselkorn T, Konstan MW, Wagener JS; Investigators and Coordinators of the Epidemiologic Study of Cystic Fibrosis; North American Scientific Advisory Group for ESCF. Schechter MS, et al. J Pediatr. 2009 Nov;155(5):634-9.e1-4. doi: 10.1016/j.jpeds.2009.04.059. Epub 2009 Jul 16. J Pediatr. 2009. PMID: 19608199 Free PMC article.
Tolerance and intolerance to continuous positive airway pressure.
Anstead M, Phillips B, Buch K. Anstead M, et al. Curr Opin Pulm Med. 1998 Nov;4(6):351-4. doi: 10.1097/00063198-199811000-00008. Curr Opin Pulm Med. 1998. PMID: 10813215 Review.
Nasal continuous positive airway pressure (CPAP) is the most effective and widely used therapy for obstructive sleep apnea. As with any chronic therapy, long-term compliance has a significant impact on its effectiveness. Only about half of patients use CPAP for more than h …
Nasal continuous positive airway pressure (CPAP) is the most effective and widely used therapy for obstructive sleep apnea. As with any chro …
The spectrum of sleep-disordered breathing.
Anstead M, Phillips B. Anstead M, et al. Respir Care Clin N Am. 1999 Sep;5(3):363-77, viii. Respir Care Clin N Am. 1999. PMID: 10419581 Review.
The term sleep-disordered breathing has been used synonymously with the term obstructive sleep apnea syndrome (OSAS). ...
The term sleep-disordered breathing has been used synonymously with the term obstructive sleep apnea syndrome (OSAS). ...