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Page 1
Musings in the twilight of my career.
Ames BN. Ames BN. Free Radic Biol Med. 2022 Jan;178:219-225. doi: 10.1016/j.freeradbiomed.2021.11.038. Epub 2021 Dec 1. Free Radic Biol Med. 2022. PMID: 34863877 Review.
I present a summary of my research during the last few decades of research which focused on understanding the biochemical basis for maintaining an optimum metabolism to support long-term health. I realized that adequate levels of 40 vitamins and minerals needed as cofactor …
I present a summary of my research during the last few decades of research which focused on understanding the biochemical basis for maintain …
Prolonging healthy aging: Longevity vitamins and proteins.
Ames BN. Ames BN. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):10836-10844. doi: 10.1073/pnas.1809045115. Epub 2018 Oct 15. Proc Natl Acad Sci U S A. 2018. PMID: 30322941 Free PMC article. Review.
It is proposed that proteins/enzymes be classified into two classes according to their essentiality for immediate survival/reproduction and their function in long-term health: that is, survival proteins versus longevity proteins. ...
It is proposed that proteins/enzymes be classified into two classes according to their essentiality for immediate survival/reproduction and …
Adaptive dysfunction of selenoproteins from the perspective of the triage theory: why modest selenium deficiency may increase risk of diseases of aging.
McCann JC, Ames BN. McCann JC, et al. Among authors: ames bn. FASEB J. 2011 Jun;25(6):1793-814. doi: 10.1096/fj.11-180885. Epub 2011 Mar 14. FASEB J. 2011. PMID: 21402715 Review.
The triage theory proposes that modest deficiency of any vitamin or mineral (V/M) could increase age-related diseases. V/M-dependent proteins required for short-term survival and/or reproduction (i.e., "essential") are predicted to be protected on V/M deficiency over other …
The triage theory proposes that modest deficiency of any vitamin or mineral (V/M) could increase age-related diseases. V/M-dependent protein …
Association of chromosome damage detected as micronuclei with hematological diseases and micronutrient status.
Lal A, Ames BN. Lal A, et al. Among authors: ames bn. Mutagenesis. 2011 Jan;26(1):57-62. doi: 10.1093/mutage/geq081. Mutagenesis. 2011. PMID: 21164183 Free PMC article. Review.
Understanding the link between micronutrient status and MN frequency will contribute towards determining optimal micronutrient intake to preserve long-term health....
Understanding the link between micronutrient status and MN frequency will contribute towards determining optimal micronutrient intake to pre …
Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?
McCann JC, Ames BN. McCann JC, et al. Among authors: ames bn. Am J Clin Nutr. 2009 Oct;90(4):889-907. doi: 10.3945/ajcn.2009.27930. Epub 2009 Aug 19. Am J Clin Nutr. 2009. PMID: 19692494 Free article. Review.
The triage theory posits that some functions of micronutrients (the approximately 40 essential vitamins, minerals, fatty acids, and amino acids) are restricted during shortage and that functions required for short-term survival take precedence over those that are less esse …
The triage theory posits that some functions of micronutrients (the approximately 40 essential vitamins, minerals, fatty acids, and amino ac …
Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts.
Killilea DW, Ames BN. Killilea DW, et al. Among authors: ames bn. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5768-73. doi: 10.1073/pnas.0712401105. Epub 2008 Apr 7. Proc Natl Acad Sci U S A. 2008. PMID: 18391207 Free PMC article.
Altered cellular physiology has been demonstrated after acute exposure to severe magnesium deficiency, but few reports have addressed the consequences of long-term exposure to moderate magnesium deficiency in human cells. Therefore, IMR-90 human fibroblasts were continuous …
Altered cellular physiology has been demonstrated after acute exposure to severe magnesium deficiency, but few reports have addressed the co …
Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests.
Milgram NW, Araujo JA, Hagen TM, Treadwell BV, Ames BN. Milgram NW, et al. Among authors: ames bn. FASEB J. 2007 Nov;21(13):3756-62. doi: 10.1096/fj.07-8531com. Epub 2007 Jul 10. FASEB J. 2007. PMID: 17622567
The improved performance on the landmark task of dogs supplemented with LA + ALC provides evidence of the effectiveness of this supplement in improving discrimination and allocentric spatial learning. We suggest that long-term maintenance on LA and ALC may be effective in …
The improved performance on the landmark task of dogs supplemented with LA + ALC provides evidence of the effectiveness of this supplement i …
Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage.
Ames BN. Ames BN. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17589-94. doi: 10.1073/pnas.0608757103. Epub 2006 Nov 13. Proc Natl Acad Sci U S A. 2006. PMID: 17101959 Free PMC article. Review.
Episodic shortages of micronutrients were common during evolution. Natural selection favors short-term survival at the expense of long-term health. I hypothesize that short-term survival was achieved by allocating scarce micronutrients by triage, in part thro …
Episodic shortages of micronutrients were common during evolution. Natural selection favors short-term survival at the expense of lon …
Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease.
Liu J, Ames BN. Liu J, et al. Among authors: ames bn. Nutr Neurosci. 2005 Apr;8(2):67-89. doi: 10.1080/10284150500047161. Nutr Neurosci. 2005. PMID: 16053240 Review.
Then, we discuss the relationships among mt-nutrient deficiency, mitochondrial decay, and cognitive dysfunction, and summarize available evidence suggesting an effect of mt-nutrient supplementation on AD and PD. It appears that greater effects might be obtained by longer-term …
Then, we discuss the relationships among mt-nutrient deficiency, mitochondrial decay, and cognitive dysfunction, and summarize available evi …
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