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Body mass trajectory from diagnosis to the end of treatment in a pediatric acute lymphoblastic leukemia cohort.
Galati PC, Rocha PRS, Gruezo ND, Amato AA. Galati PC, et al. Among authors: amato aa. Sci Rep. 2023 Aug 21;13(1):13590. doi: 10.1038/s41598-023-39287-z. Sci Rep. 2023. PMID: 37604919 Free PMC article.
Obesity development is frequent following ALL therapy and may significantly contribute to long-term morbidity and mortality. We examined the body mass trajectory of 208 children with ALL, from the diagnosis to the completion of therapy. ...
Obesity development is frequent following ALL therapy and may significantly contribute to long-term morbidity and mortality. We exami …
Efficacy and Safety of Bimagrumab in Sporadic Inclusion Body Myositis: Long-term Extension of RESILIENT.
Amato AA, Hanna MG, Machado PM, Badrising UA, Chinoy H, Benveniste O, Karanam AK, Wu M, Tankó LB, Schubert-Tennigkeit AA, Papanicolaou DA, Lloyd TE, Needham M, Liang C, Reardon KA, de Visser M, Ascherman DP, Barohn RJ, Dimachkie MM, Miller JAL, Kissel JT, Oskarsson B, Joyce NC, Van den Bergh P, Baets J, De Bleecker JL, Karam C, David WS, Mirabella M, Nations SP, Jung HH, Pegoraro E, Maggi L, Rodolico C, Filosto M, Shaibani AI, Sivakumar K, Goyal NA, Mori-Yoshimura M, Yamashita S, Suzuki N, Aoki M, Katsuno M, Morihata H, Murata K, Nodera H, Nishino I, Romano CD, Williams VSL, Vissing J, Zhang Auberson L; RESILIENT Study Extension Group. Amato AA, et al. Neurology. 2021 Mar 23;96(12):e1595-e1607. doi: 10.1212/WNL.0000000000011626. Epub 2021 Feb 17. Neurology. 2021. PMID: 33597289 Free PMC article. Clinical Trial.
OBJECTIVE: To assess long-term (2 years) effects of bimagrumab in participants with sporadic inclusion body myositis (sIBM). ...CLASSIFICATION OF EVIDENCE: This study provides Class IV evidence that for patients with sIBM, long-term treatment with bimagrumab was saf …
OBJECTIVE: To assess long-term (2 years) effects of bimagrumab in participants with sporadic inclusion body myositis (sIBM). ...CLASS …
Long-term safety and tolerability of bimagrumab (BYM338) in sporadic inclusion body myositis.
Sivakumar K, Cochrane TI, Sloth B, Ashar H, Laurent D, Tankó LB, Amato AA. Sivakumar K, et al. Among authors: amato aa. Neurology. 2020 Oct 6;95(14):e1971-e1978. doi: 10.1212/WNL.0000000000010417. Epub 2020 Jul 20. Neurology. 2020. PMID: 32690797 Clinical Trial.
OBJECTIVE: To assess the long-term safety and tolerability and to monitor benefits of extended use of bimagrumab in individuals with sporadic inclusion body myositis (sIBM) who completed a single-dose core study. ...CLASSIFICATION OF EVIDENCE: This study provides Class IV …
OBJECTIVE: To assess the long-term safety and tolerability and to monitor benefits of extended use of bimagrumab in individuals with …
Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial.
Wolfe GI, Kaminski HJ, Aban IB, Minisman G, Kuo HC, Marx A, Ströbel P, Mazia C, Oger J, Cea JG, Heckmann JM, Evoli A, Nix W, Ciafaloni E, Antonini G, Witoonpanich R, King JO, Beydoun SR, Chalk CH, Barboi AC, Amato AA, Shaibani AI, Katirji B, Lecky BRF, Buckley C, Vincent A, Dias-Tosta E, Yoshikawa H, Waddington-Cruz M, Pulley MT, Rivner MH, Kostera-Pruszczyk A, Pascuzzi RM, Jackson CE, Verschuuren JJGM, Massey JM, Kissel JT, Werneck LC, Benatar M, Barohn RJ, Tandan R, Mozaffar T, Silvestri NJ, Conwit R, Sonett JR, Jaretzki A 3rd, Newsom-Davis J, Cutter GR; MGTX Study Group. Wolfe GI, et al. Among authors: amato aa. Lancet Neurol. 2019 Mar;18(3):259-268. doi: 10.1016/S1474-4422(18)30392-2. Epub 2019 Jan 25. Lancet Neurol. 2019. PMID: 30692052 Free PMC article. Clinical Trial.
BACKGROUND: The Thymectomy Trial in Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone (MGTX) showed that thymectomy combined with prednisone was superior to prednisone alone in improving clinical status as measured by the Quantitative Myasthenia Gravis (QMG) score i …
BACKGROUND: The Thymectomy Trial in Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone (MGTX) showed that thymectomy combined w …
The effect of glucagon-like peptide 1 and glucagon-like peptide 1 receptor agonists on energy expenditure: A systematic review and meta-analysis.
Maciel MG, Beserra BTS, Oliveira FCB, Ribeiro CM, Coelho MS, Neves FAR, Amato AA. Maciel MG, et al. Among authors: amato aa. Diabetes Res Clin Pract. 2018 Aug;142:222-235. doi: 10.1016/j.diabres.2018.05.034. Epub 2018 May 30. Diabetes Res Clin Pract. 2018. PMID: 29857094 Review.
Importantly, the longest trial with GLP-1RA reported a significant increase in REE in response to treatment with both exenatide or liraglutide and most trials reported that GLP-1RA-induced weight loss was not accompanied by decreased REE. CONCLUSIONS: This review indicates that G …
Importantly, the longest trial with GLP-1RA reported a significant increase in REE in response to treatment with both exenatide or liragluti …
Decaffeinated coffee improves insulin sensitivity in healthy men.
Reis CEG, Paiva CLRDS, Amato AA, Lofrano-Porto A, Wassell S, Bluck LJC, Dórea JG, da Costa THM. Reis CEG, et al. Among authors: amato aa. Br J Nutr. 2018 May;119(9):1029-1038. doi: 10.1017/S000711451800034X. Epub 2018 Mar 8. Br J Nutr. 2018. PMID: 29514721 Clinical Trial.
Our findings demonstrated that the consumption of decaffeinated coffee improves insulin sensitivity without changing incretin hormones levels. There was no short-term adverse effect on glucose homoeostasis, after an oral glucose challenge, attributable to the consumption o …
Our findings demonstrated that the consumption of decaffeinated coffee improves insulin sensitivity without changing incretin hormones level …
Longer Telomere Length in Elite Master Sprinters: Relationship to Performance and Body Composition.
Simoes HG, Sousa CV, Dos Santos Rosa T, da Silva Aguiar S, Deus LA, Rosa ECCC, Amato AA, Andrade RV. Simoes HG, et al. Among authors: amato aa. Int J Sports Med. 2017 Dec;38(14):1111-1116. doi: 10.1055/s-0043-120345. Epub 2017 Nov 3. Int J Sports Med. 2017. PMID: 29100249
Emergent evidence suggests that the long-term healthy lifestyle of master athletes may attenuate aging. We compared telomere length (TL) of high-level master sprinters and non-athlete age-matched controls, and analyzed the relationships of TL with performance and body fat. …
Emergent evidence suggests that the long-term healthy lifestyle of master athletes may attenuate aging. We compared telomere length ( …
Idealized PPARγ-Based Therapies: Lessons from Bench and Bedside.
Amato AA, de Assis Rocha Neves F. Amato AA, et al. PPAR Res. 2012;2012:978687. doi: 10.1155/2012/978687. Epub 2012 Jun 14. PPAR Res. 2012. PMID: 22745632 Free PMC article.
Currently marketed drugs targeting this receptor, the thiazolidinediones (TZDs), have proven benefits on insulin resistance and hyperglycemia associated with T2D. Unfortunately, they have been associated with long-term unfavorable effects on health, such as weight gain, pl …
Currently marketed drugs targeting this receptor, the thiazolidinediones (TZDs), have proven benefits on insulin resistance and hyperglycemi …
Neuromuscular complications of cancer.
Briemberg HR, Amato AA. Briemberg HR, et al. Among authors: amato aa. Neurol Clin. 2003 Feb;21(1):141-65. doi: 10.1016/s0733-8619(02)00028-2. Neurol Clin. 2003. PMID: 12690648 Review.
Recognition of iatrogenic neuromuscular complications is also important to modify treatment protocols when possible and thus decrease the risk of long-term neurologic disability....
Recognition of iatrogenic neuromuscular complications is also important to modify treatment protocols when possible and thus decrease the ri …
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