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Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys.
Dehnadi A, Benedict Cosimi A, Neal Smith R, Li X, Alonso JL, Means TK, Arnaout MA. Dehnadi A, et al. Among authors: alonso jl. Nat Commun. 2017 Jan 10;8:13899. doi: 10.1038/ncomms13899. Nat Commun. 2017. PMID: 28071653 Free PMC article.
Moreover, prophylactic inactivation of CD11b/CD18, using the orthosteric CD11b/CD18 inhibitor mAb107, improves microvascular perfusion and histopathology, reduces intrarenal pro-inflammatory mediators and salvages kidney function long term. These studies reveal an importan …
Moreover, prophylactic inactivation of CD11b/CD18, using the orthosteric CD11b/CD18 inhibitor mAb107, improves microvascular perfusion and h …
High-Resolution Rotational Spectroscopy of a Cyclic Ether.
Gámez F, Martínez-Haya B, Blanco S, López JC, Alonso JL. Gámez F, et al. Among authors: alonso jl. J Phys Chem Lett. 2012 Feb 16;3(4):482-5. doi: 10.1021/jz201678w. Epub 2012 Jan 31. J Phys Chem Lett. 2012. PMID: 26286051
The results pave the ground for an extensive survey of the conformational landscape of the 15-crown-5 and related cyclic ethers in the near term....
The results pave the ground for an extensive survey of the conformational landscape of the 15-crown-5 and related cyclic ethers in the near …
Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): a prespecified subgroup analysis of a randomised controlled trial.
Decramer M, Celli B, Kesten S, Lystig T, Mehra S, Tashkin DP; UPLIFT investigators. Decramer M, et al. Lancet. 2009 Oct 3;374(9696):1171-8. doi: 10.1016/S0140-6736(09)61298-8. Epub 2009 Aug 27. Lancet. 2009. PMID: 19716598 Clinical Trial.
We examined the effect of tiotropium on outcomes in a large subgroup of patients with moderate COPD. METHODS: The Understanding Potential Long-Term Impacts on Function with Tiotropium (UPLIFT) study was a randomised, double-blind, placebo-controlled trial undertaken in 487 …
We examined the effect of tiotropium on outcomes in a large subgroup of patients with moderate COPD. METHODS: The Understanding Potential Lo …
[Intestinal pseudo-obstruction secondary to systemic neuropathies and myopathies].
García Aroca J, Sanz N, Alonso JL, de Mingo L, Rollán V. García Aroca J, et al. Among authors: alonso jl. Cir Pediatr. 1994 Jul;7(3):115-20. Cir Pediatr. 1994. PMID: 7999513 Review. Spanish.
The term intestinal pseudo-obstruction, is applied to a group of clinical disorders in which there are obstructive symptoms, in the absence of a mechanical agent, secondary to a disorder of intestinal motility. ...
The term intestinal pseudo-obstruction, is applied to a group of clinical disorders in which there are obstructive symptoms, in the a …
[Evaluation of the efficacy of chelation therapy with deferoxamine in patients with thalassemia major].
Rodríguez Galindo C, Ortega Aramburu JJ, Alonso JL, Albisu M, Casaldáliga J, Díaz de Heredia C, Olivé T, Bastida P. Rodríguez Galindo C, et al. Among authors: alonso jl. Med Clin (Barc). 1994 May 21;102(19):721-4. Med Clin (Barc). 1994. PMID: 8041200 Spanish.
BACKGROUND: The current treatment of thalassaemia maior (TM) is based on a hypertransfusion regimen, with deferoxamine (DFO) chelation therapy to minimize the consequences of iron overload. To evaluate the long-term efficacy of chelation therapy, a group of 9 patients trea …
BACKGROUND: The current treatment of thalassaemia maior (TM) is based on a hypertransfusion regimen, with deferoxamine (DFO) chelation thera …