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Impact of sustained calorie restriction and weight cycling on body composition in high-fat diet-fed male and female C57BL/6J mice.
Smith DL Jr, Yang Y, Mestre LM, Henschel B, Parker E, Dickinson S, Patki A, Allison DB, Nagy TR. Smith DL Jr, et al. Among authors: allison db. Obesity (Silver Spring). 2024 May;32(5):959-968. doi: 10.1002/oby.24015. Epub 2024 Apr 10. Obesity (Silver Spring). 2024. PMID: 38600047
RESULTS: Although weight loss and regain resulted in changes in body weight and composition, fat mass, body weight, and relative body fat were not significantly greater for the WC group compared with the EO group. During long-term calorie restriction, males (but not female …
RESULTS: Although weight loss and regain resulted in changes in body weight and composition, fat mass, body weight, and relative body fat we …
Prevalence of Distal Symmetrical Polyneuropathy by Diabetes Prevention Program Treatment Group, Diabetes Status, Duration of Diabetes, and Cumulative Glycemic Exposure.
Lee CG, Ciarleglio A, Edelstein SL, Crandall JP, Dabelea D, Goldberg RB, Kahn SE, Knowler WC, Ma MT, White NH, Herman WH; Diabetes Prevention Program Research Group. Lee CG, et al. Diabetes Care. 2024 May 1;47(5):810-817. doi: 10.2337/dc23-2009. Diabetes Care. 2024. PMID: 38502874 Clinical Trial.
CONCLUSIONS: The likelihood of DSPN was similar across DPP treatment groups but higher for those with diabetes, longer diabetes duration, and higher cumulative glycemic exposure. ILS may have long-term benefits on DSPN for older adults....
CONCLUSIONS: The likelihood of DSPN was similar across DPP treatment groups but higher for those with diabetes, longer diabetes duration, an …
Pharmacotherapy for obesity: recent evolution and implications for cardiovascular risk reduction.
Maki KC, Kirkpatrick CF, Allison DB, Gadde KM. Maki KC, et al. Among authors: allison db. Expert Rev Endocrinol Metab. 2023 Sep-Nov;18(4):307-319. doi: 10.1080/17446651.2023.2209176. Epub 2023 May 18. Expert Rev Endocrinol Metab. 2023. PMID: 37199542 Review.
The use of medications to treat obesity is relatively rare. In part, this reflects concerns about long-term safety and weight loss effectiveness, possible provider bias, as well as lack of clear evidence of MACE risk reduction. ...
The use of medications to treat obesity is relatively rare. In part, this reflects concerns about long-term safety and weight loss ef …
Effectiveness of lactation cookies on human milk production rates: a randomized controlled trial.
Palacios AM, Cardel MI, Parker E, Dickinson S, Houin VR, Young B, Allison DB. Palacios AM, et al. Among authors: allison db. Am J Clin Nutr. 2023 May;117(5):1035-1042. doi: 10.1016/j.ajcnut.2023.03.010. Epub 2023 Mar 14. Am J Clin Nutr. 2023. PMID: 36921902 Free article. Clinical Trial.
METHODS: This is a 1-mo, randomized controlled trial among 18-45-y-old exclusively lactating parents of healthy, term, 2-mo-old infants living in the United States from March to December 2021. ...
METHODS: This is a 1-mo, randomized controlled trial among 18-45-y-old exclusively lactating parents of healthy, term, 2-mo-old infan …
The 2018 World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) score and diabetes risk in the Diabetes Prevention Program Outcomes Study (DPPOS).
Shams-White MM, Tjaden AH, Edelstein SL, Bassiouni S, Kahle LL, Kim C, Pi-Sunyer X, Temple KA, Venditti EM, Reedy J, Heckman-Stoddard BM; DPP Research Group. Shams-White MM, et al. BMC Nutr. 2022 Sep 21;8(1):105. doi: 10.1186/s40795-022-00596-7. BMC Nutr. 2022. PMID: 36131333 Free PMC article.
Score changes from years 0-1 and time-dependent Score changes in ILS and PLB remained associated with lower risk through year 15. CONCLUSIONS: Score improvements were associated with long-term, lower diabetes risk among high-risk adults randomized to ILS and PLB, but not M …
Score changes from years 0-1 and time-dependent Score changes in ILS and PLB remained associated with lower risk through year 15. CONCLUSION …
Circadian disruption of hippocampus in an early senescence male mouse model.
Davis JA, Paul JR, Mokashi MV, Yates SA, Mount DJ, Munir HA, Goode LK, Young ME, Allison DB, Gamble KL. Davis JA, et al. Among authors: allison db. Pharmacol Biochem Behav. 2022 Jun;217:173388. doi: 10.1016/j.pbb.2022.173388. Epub 2022 Apr 18. Pharmacol Biochem Behav. 2022. PMID: 35447158 Free PMC article.
We also examined time-restricted feeding as a potential strategy to rescue disrupted hippocampal plasticity. Time-restricted feeding increased long-term potentiation at Schaffer collateral-CA1 synapses in SAMP8 mice (compared to SAMR1 controls). ...
We also examined time-restricted feeding as a potential strategy to rescue disrupted hippocampal plasticity. Time-restricted feeding increas …
SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3.
Tripathi U, Nchioua R, Prata LGPL, Zhu Y, Gerdes EOW, Giorgadze N, Pirtskhalava T, Parker E, Xue A, Espindola-Netto JM, Stenger S, Robbins PD, Niedernhofer LJ, Dickinson SL, Allison DB, Kirchhoff F, Sparrer KMJ, Tchkonia T, Kirkland JL. Tripathi U, et al. Among authors: allison db. Aging (Albany NY). 2021 Sep 16;13(18):21838-21854. doi: 10.18632/aging.203560. Epub 2021 Sep 16. Aging (Albany NY). 2021. PMID: 34531331 Free PMC article.
Our results suggest that induction of cellular senescence and SASP amplification through TLR-3 contribute to SARS-CoV-2 morbidity, indicating that clinical trials of senolytics and/or SASP/TLR-3 inhibitors for alleviating acute and long-term SARS-CoV-2 sequelae are warrant …
Our results suggest that induction of cellular senescence and SASP amplification through TLR-3 contribute to SARS-CoV-2 morbidity, indicatin …
Pathology Residency Program Special Expertise Tracks Meet the Needs of an Evolving Field.
Wake LM, Allison DB, Ware AD, Hooper JE, Baras AS, Bloch EM, Clarke W, Burns KH, Sfanos KS, Borowitz MJ, Steenbergen C, Hruban RH, White MJ. Wake LM, et al. Among authors: allison db. Acad Pathol. 2021 Aug 31;8:23742895211037034. doi: 10.1177/23742895211037034. eCollection 2021 Jan-Dec. Acad Pathol. 2021. PMID: 34485688 Free PMC article.
Currently, 5 residents are pursuing the Education track, one is pursuing the Physician-Scientist Research track, one is pursuing the Informatics track, and 2 residents are pursuing the Global Health track. Five residents have completed long-term projects including developi …
Currently, 5 residents are pursuing the Education track, one is pursuing the Physician-Scientist Research track, one is pursuing the Informa …
The Impact of Physical Activity on the Prevention of Type 2 Diabetes: Evidence and Lessons Learned From the Diabetes Prevention Program, a Long-Standing Clinical Trial Incorporating Subjective and Objective Activity Measures.
Kriska AM, Rockette-Wagner B, Edelstein SL, Bray GA, Delahanty LM, Hoskin MA, Horton ES, Venditti EM, Knowler WC; DPP Research Group. Kriska AM, et al. Diabetes Care. 2021 Jan;44(1):43-49. doi: 10.2337/dc20-1129. Epub 2020 Nov 10. Diabetes Care. 2021. PMID: 33444158 Free PMC article. Clinical Trial.
Collection of self-reported physical activity (PA) (yearly) with cross-sectional objective PA (in follow-up) allowed for examination of PA and its long-term impact on diabetes prevention. RESEARCH DESIGN AND METHODS: Yearly self-reported PA and diabetes assessment and oral …
Collection of self-reported physical activity (PA) (yearly) with cross-sectional objective PA (in follow-up) allowed for examination of PA a …
Diabetes medications as potential calorie restriction mimetics-a focus on the alpha-glucosidase inhibitor acarbose.
Smith DL Jr, Orlandella RM, Allison DB, Norian LA. Smith DL Jr, et al. Among authors: allison db. Geroscience. 2021 Jun;43(3):1123-1133. doi: 10.1007/s11357-020-00278-x. Epub 2020 Oct 2. Geroscience. 2021. PMID: 33006707 Free PMC article.
Coincident with this increase in knowledge has been the rise of obesity and type 2 diabetes (T2D), both associated with increased morbidity and mortality. Given the difficulty in practicing long-term CR, a search for compounds (CR mimetics) which could recapitulate the hea …
Coincident with this increase in knowledge has been the rise of obesity and type 2 diabetes (T2D), both associated with increased morbidity …
52 results