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A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results.
Rappaport AR, Kyi C, Lane M, Hart MG, Johnson ML, Henick BS, Liao CY, Mahipal A, Shergill A, Spira AI, Goldman JW, Scallan CD, Schenk D, Palmer CD, Davis MJ, Kounlavouth S, Kemp L, Yang A, Li YJ, Likes M, Shen A, Boucher GR, Egorova M, Veres RL, Espinosa JA, Jaroslavsky JR, Kraemer Tardif LD, Acrebuche L, Puccia C, Sousa L, Zhou R, Bae K, Hecht JR, Carbone DP, Johnson B, Allen A, Ferguson AR, Jooss K. Rappaport AR, et al. Among authors: allen a. Nat Med. 2024 Apr;30(4):1013-1022. doi: 10.1038/s41591-024-02851-9. Epub 2024 Mar 27. Nat Med. 2024. PMID: 38538867 Clinical Trial.
Therapeutic vaccines that elicit cytotoxic T cell responses targeting tumor-specific neoantigens hold promise for providing long-term clinical benefit to patients with cancer. Here we evaluated safety and tolerability of a therapeutic vaccine encoding 20 shared neoantigens …
Therapeutic vaccines that elicit cytotoxic T cell responses targeting tumor-specific neoantigens hold promise for providing long-term …
Prevalence of Distal Symmetrical Polyneuropathy by Diabetes Prevention Program Treatment Group, Diabetes Status, Duration of Diabetes, and Cumulative Glycemic Exposure.
Lee CG, Ciarleglio A, Edelstein SL, Crandall JP, Dabelea D, Goldberg RB, Kahn SE, Knowler WC, Ma MT, White NH, Herman WH; Diabetes Prevention Program Research Group. Lee CG, et al. Diabetes Care. 2024 May 1;47(5):810-817. doi: 10.2337/dc23-2009. Diabetes Care. 2024. PMID: 38502874 Clinical Trial.
CONCLUSIONS: The likelihood of DSPN was similar across DPP treatment groups but higher for those with diabetes, longer diabetes duration, and higher cumulative glycemic exposure. ILS may have long-term benefits on DSPN for older adults....
CONCLUSIONS: The likelihood of DSPN was similar across DPP treatment groups but higher for those with diabetes, longer diabetes duration, an …
Pregnancy Outcomes After Laparoscopic Radiofrequency Ablation of Uterine Leiomyomas Compared With Myomectomy.
Allen A, Schembri M, Parvataneni R, Waetjen LE, Varon S, Salamat-Saberi N, Tassone S, Williams N, Kho KA, Jacoby VL. Allen A, et al. Obstet Gynecol. 2024 May 1;143(5):612-618. doi: 10.1097/AOG.0000000000005548. Epub 2024 Mar 1. Obstet Gynecol. 2024. PMID: 38422502
There were no significant differences in the likelihood of live birth or miscarriage between the study groups. CONCLUSION: Full-term pregnancy and vaginal delivery are achievable after radiofrequency ablation of leiomyomas. However, in this interim analysis, the mis …
There were no significant differences in the likelihood of live birth or miscarriage between the study groups. CONCLUSION: Full-te …
Assessing brain integrity in patients with long-term and well-functioning metal-based hip implants.
Taleb S, Varela-Mattatall G, Allen A, Haast R, Khan AR, Kalia V, Howard JL, MacDonald SJ, Menon RS, Lanting BA, Teeter MG. Taleb S, et al. Among authors: allen a. J Orthop Res. 2024 Jun;42(6):1292-1302. doi: 10.1002/jor.25785. Epub 2024 Jan 18. J Orthop Res. 2024. PMID: 38235918
Our objective was tosimultaneously analyze brain anatomy and physiology in patients with long-term and well-functioning implants. Included were subjects who had received total hip or hip resurfacing arthroplastywith an implantation time of a minimum of 7 years (n = 28) and …
Our objective was tosimultaneously analyze brain anatomy and physiology in patients with long-term and well-functioning implants. Inc …
Global survey of stigma among physicians and patients with nonalcoholic fatty liver disease.
Younossi ZM, Alqahtani SA, Alswat K, Yilmaz Y, Keklikkiran C, Funuyet-Salas J, Romero-Gómez M, Fan JG, Zheng MH, El-Kassas M, Castera L, Liu CJ, Wai-Sun Wong V, Zelber-Sagi S, Allen AM, Lam B, Treeprasertsuk S, Hameed S, Takahashi H, Kawaguchi T, Schattenberg JM, Duseja A, Newsome PN, Francque S, Spearman CW, Castellanos Fernández MI, Burra P, Roberts SK, Chan WK, Arrese M, Silva M, Rinella M, Singal AK, Gordon S, Fuchs M, Alkhouri N, Cusi K, Loomba R, Ranagan J, Eskridge W, Kautz A, Ong JP, Kugelmas M, Eguchi Y, Diago M, Yu ML, Gerber L, Fornaresio L, Nader F, Henry L, Racila A, Golabi P, Stepanova M, Carrieri P, Lazarus JV; Global NASH Council. Younossi ZM, et al. Among authors: allen am. J Hepatol. 2024 Mar;80(3):419-430. doi: 10.1016/j.jhep.2023.11.004. Epub 2023 Nov 18. J Hepatol. 2024. PMID: 37984709
Of all patients, 48% ever disclosed having NAFLD/NASH to family/friends; the most commonly used term was "fatty liver" (88% at least sometimes); "metabolic disease" or "MAFLD" were rarely used (never by >84%). ...The most popular response was being neither comfortable n …
Of all patients, 48% ever disclosed having NAFLD/NASH to family/friends; the most commonly used term was "fatty liver" (88% at least …
Short-term acidification promotes diverse iron acquisition and conservation mechanisms in upwelling-associated phytoplankton.
Lampe RH, Coale TH, Forsch KO, Jabre LJ, Kekuewa S, Bertrand EM, Horák A, Oborník M, Rabines AJ, Rowland E, Zheng H, Andersson AJ, Barbeau KA, Allen AE. Lampe RH, et al. Among authors: allen ae. Nat Commun. 2023 Nov 8;14(1):7215. doi: 10.1038/s41467-023-42949-1. Nat Commun. 2023. PMID: 37940668 Free PMC article.
Here we show from community to molecular levels that phytoplankton in an upwelling region respond to short-term acidification exposure with iron uptake pathways and strategies that reduce cellular iron demand. ...Growth, nutrient uptake, and community compositions remained …
Here we show from community to molecular levels that phytoplankton in an upwelling region respond to short-term acidification exposur …
Temporal and Probabilistic Comparisons of Epidemic Interventions.
Boudreau MC, Allen AJ, Roberts NJ, Allard A, Hébert-Dufresne L. Boudreau MC, et al. Among authors: allen aj. Bull Math Biol. 2023 Oct 19;85(12):118. doi: 10.1007/s11538-023-01220-w. Bull Math Biol. 2023. PMID: 37857996
Given that epidemics do not always follow their average expected trajectories and that the underlying dynamics can change over time, our work paves the way for more detailed short-term forecasts of disease spread and more informed comparison of intervention strategies....
Given that epidemics do not always follow their average expected trajectories and that the underlying dynamics can change over time, our wor …
Development, validation, and prognostic evaluation of a risk score for long-term liver-related outcomes in the general population: a multicohort study.
Serra-Burriel M, Juanola A, Serra-Burriel F, Thiele M, Graupera I, Pose E, Pera G, Grgurevic I, Caballeria L, Piano S, van Kleef L, Reichert M, Roulot D, Pericàs JM, Schattenberg JM, Tsochatztis EA, Guha IN, Garcia-Retortillo M, Hernández R, Hoyo J, Fuentes M, Expósito C, Martínez A, Such P, Madir A, Detlefsen S, Tonon M, Martini A, Ma AT, Pich J, Bonfill E, Juan M, Soria A, Carol M, Gratacós-Ginès J, Morillas RM, Toran P, Navarrete JM, Torrejón A, Fournier C, Llorca A, Arslanow A, de Koning HJ, Cucchietti F, Manns M, Newsome PN, Hernáez R, Allen A, Angeli P, de Knegt RJ, Karlsen TH, Galle P, Wong VW, Fabrellas N, Castera L, Krag A, Lammert F, Kamath PS, Ginès P; LiverScreen Consortium Investigators. Serra-Burriel M, et al. Among authors: allen a. Lancet. 2023 Sep 16;402(10406):988-996. doi: 10.1016/S0140-6736(23)01174-1. Epub 2023 Aug 9. Lancet. 2023. PMID: 37572680
Epidemiology of pediatric trauma and fractures during and beyond the COVID-19 pandemic.
Butler LR, Abbott E, Mengsteab P, Dominy CL, Poeran J, Allen AK, Ranade SC. Butler LR, et al. Among authors: allen ak. J Child Orthop. 2023 Jun 19;17(4):322-331. doi: 10.1177/18632521231180161. eCollection 2023 Aug. J Child Orthop. 2023. PMID: 37560351 Free PMC article.
These trends have mostly persisted for 12 months post-peak pandemic. This longitudinal analysis helps inform and improve long-term critical care and public health resource allocation for the future. ...
These trends have mostly persisted for 12 months post-peak pandemic. This longitudinal analysis helps inform and improve long-term cr …
Physician assessment of aortic stenosis severity, quantitative parameters, and long-term outcomes: Results from the KP-VALVE project.
Solomon MD, Tabada G, Sung SH, Allen A, Mishell JM, Rassi AN, McNulty E, Philip F, Lange DC, Ambrosy AP, Zaroff JG, Krishnaswami A, Lee C, DeMaria A, Nishimura R, Go AS. Solomon MD, et al. Among authors: allen a. Am Heart J. 2023 Dec;266:32-47. doi: 10.1016/j.ahj.2023.07.009. Epub 2023 Aug 6. Am Heart J. 2023. PMID: 37553045
189 results