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Prospective genomically guided identification of "early/evolving" and "undersampled" IDH-wildtype glioblastoma leads to improved clinical outcomes.
Zhang Y, Lucas CG, Young JS, Morshed RA, McCoy L, Oberheim Bush NA, Taylor JW, Daras M, Butowski NA, Villanueva-Meyer JE, Cha S, Wrensch M, Wiencke JK, Lee JC, Pekmezci M, Phillips JJ, Perry A, Bollen AW, Aghi MK, Theodosopoulos P, Chang EF, Hervey-Jumper SL, Berger MS, Clarke JL, Chang SM, Molinaro AM, Solomon DA. Zhang Y, et al. Among authors: aghi mk. Neuro Oncol. 2022 Oct 3;24(10):1749-1762. doi: 10.1093/neuonc/noac089. Neuro Oncol. 2022. PMID: 35395677 Free PMC article.
RESULTS: We identified that this diagnosis consists of two divergent clinical scenarios based on integration of radiologic, histologic, and genomic features that we term "early/evolving" and "undersampled" glioblastoma, IDH-wildtype. ...
RESULTS: We identified that this diagnosis consists of two divergent clinical scenarios based on integration of radiologic, histologic, and …
Effect of facility volume on giant pituitary adenoma neurosurgical outcomes.
Chalif EJ, Couldwell WT, Aghi MK. Chalif EJ, et al. Among authors: aghi mk. J Neurosurg. 2022 Jan 14:1-10. doi: 10.3171/2021.11.JNS211936. Online ahead of print. J Neurosurg. 2022. PMID: 35171824
Univariate and multivariate logistic regression modeling was used to evaluate the prognostic impact of covariates on short-term outcomes including 30-day readmission (30R), 30-day mortality (30M), 90-day mortality (90M), and prolonged length of inpatient hospital stay (LOS …
Univariate and multivariate logistic regression modeling was used to evaluate the prognostic impact of covariates on short-term outco …
Socioeconomic predictors of case presentations and outcomes in 225 nonfunctional pituitary adenoma resections.
Osorio RC, Pereira MP, Joshi RS, Donohue KC, Sneed P, Braunstein S, Theodosopoulos PV, El-Sayed IH, Gurrola J, Kunwar S, Blevins LS, Aghi MK. Osorio RC, et al. Among authors: aghi mk. J Neurosurg. 2021 Oct 1:1-12. doi: 10.3171/2021.4.JNS21907. Online ahead of print. J Neurosurg. 2021. PMID: 34598141
These markers were correlated with presenting tumor burden, presenting symptoms, surgical outcomes, and long-term clinical outcomes. RESULTS: All 5 examined SES markers influenced variance in patient presentation or outcome. ...
These markers were correlated with presenting tumor burden, presenting symptoms, surgical outcomes, and long-term clinical outcomes. …
Meningioma surgical outcomes and complications in patients aged 75 years and older.
Ekaireb RI, Edwards CS, Ali MS, Nguyen MP, Daggubati V, Aghi MK, Theodosopoulos PV, McDermott MW, Magill ST. Ekaireb RI, et al. Among authors: aghi mk. J Clin Neurosci. 2021 Jun;88:88-94. doi: 10.1016/j.jocn.2021.03.032. Epub 2021 Apr 1. J Clin Neurosci. 2021. PMID: 33992210
While there is morbidity associated with meningioma resection in this cohort, there is also excellent long-term survival....
While there is morbidity associated with meningioma resection in this cohort, there is also excellent long-term survival....
Convection-enhanced drug delivery for glioblastoma: a review.
D'Amico RS, Aghi MK, Vogelbaum MA, Bruce JN. D'Amico RS, et al. Among authors: aghi mk. J Neurooncol. 2021 Feb;151(3):415-427. doi: 10.1007/s11060-020-03408-9. Epub 2021 Feb 21. J Neurooncol. 2021. PMID: 33611708 Free PMC article. Review.
However, the heterogeneity of both, the surgical procedure and the mechanisms of action of the agents studied-combined with the additional costs of performing a trial evaluating CED-has limited the field's ability to adequately assess the durability of any potential anti-tumor re …
However, the heterogeneity of both, the surgical procedure and the mechanisms of action of the agents studied-combined with the additional c …
Comparative Analysis of Survival Outcomes and Prognostic Factors of Supratentorial versus Cerebellar Glioblastoma in the Elderly: Does Location Really Matter?
Chandra A, Lopez-Rivera V, Dono A, Brandel MG, Lewis C, O'Connor KP, Sheth SA, Ballester LY, Aghi MK, Esquenazi Y. Chandra A, et al. Among authors: aghi mk. World Neurosurg. 2021 Feb;146:e755-e767. doi: 10.1016/j.wneu.2020.11.003. Epub 2020 Nov 7. World Neurosurg. 2021. PMID: 33171326

Patients with cGBM and stGBM undergoing radiotherapy (7 months vs. 2 months; P < 0.001) and chemotherapy (10 months vs. 3 months; P < 0.0001) had improved survival. Long-term mortality was lower for cGBM in the elderly at 24 months compared with the stGBM cohort (P =

Patients with cGBM and stGBM undergoing radiotherapy (7 months vs. 2 months; P < 0.001) and chemotherapy (10 months vs. 3 months; P <

Atypical meningiomas.
Chen R, Aghi MK. Chen R, et al. Among authors: aghi mk. Handb Clin Neurol. 2020;170:233-244. doi: 10.1016/B978-0-12-822198-3.00043-4. Handb Clin Neurol. 2020. PMID: 32586495 Review.
Here we review the clinical features, treatment, and outcomes of atypical meningiomas, with a focus on the impact of extent of resection and radiation therapy on the long-term recurrence rate of completely and incompletely resected atypical meningiomas....
Here we review the clinical features, treatment, and outcomes of atypical meningiomas, with a focus on the impact of extent of resection and …
Clinical characteristics and outcomes of null-cell versus silent gonadotroph adenomas in a series of 1166 pituitary adenomas from a single institution.
Haddad AF, Young JS, Oh T, Pereira MP, Joshi RS, Pereira KM, Osorio RC, Donohue KC, Peeran Z, Sudhir S, Jain S, Beniwal A, Chopra AS, Sandhu NS, Theodosopoulos PV, Kunwar S, El-Sayed IH, Gurrola J, Blevins LS, Aghi MK. Haddad AF, et al. Among authors: aghi mk. Neurosurg Focus. 2020 Jun;48(6):E13. doi: 10.3171/2020.3.FOCUS20114. Neurosurg Focus. 2020. PMID: 32480370
There were no differences in patient demographics, initial tumor size, or perioperative and short-term clinical outcomes. There was no significant difference in the amount of follow-up between patients with NCAs and those with SGAs (33.8 months vs 29.1 months, p = 0.237). …
There were no differences in patient demographics, initial tumor size, or perioperative and short-term clinical outcomes. There was n …
Surgical Outcomes, Complications, and Management Strategies for Foramen Magnum Meningiomas.
Magill ST, Shahin MN, Lucas CG, Yen AJ, Lee DS, Raleigh DR, Aghi MK, Theodosopoulos PV, McDermott MW. Magill ST, et al. Among authors: aghi mk. J Neurol Surg B Skull Base. 2019 Feb;80(1):1-9. doi: 10.1055/s-0038-1654702. Epub 2018 May 28. J Neurol Surg B Skull Base. 2019. PMID: 30733894 Free PMC article.
Conclusions Resection of FMM carries perioperative morbidity that increases with larger tumor size. Despite the morbidity, long-term recurrence-free survival is achievable with maximal safe resection and adjuvant radiation....
Conclusions Resection of FMM carries perioperative morbidity that increases with larger tumor size. Despite the morbidity, long-term
Surgical outcomes after reoperation for recurrent non-skull base meningiomas.
Magill ST, Dalle Ore CL, Diaz MA, Jalili DD, Raleigh DR, Aghi MK, Theodosopoulos PV, McDermott MW. Magill ST, et al. Among authors: aghi mk. J Neurosurg. 2018 Nov 1:1-9. doi: 10.3171/2018.6.JNS18118. Online ahead of print. J Neurosurg. 2018. PMID: 30544357
Patients with cognitive changes and tumors that overlap the middle third of the sagittal plane are at increased risk of complications. Nevertheless, excellent long-term survival can be achieved without perioperative mortality....
Patients with cognitive changes and tumors that overlap the middle third of the sagittal plane are at increased risk of complications. Never …
29 results