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A phage nucleus-associated RNA-binding protein is required for jumbo phage infection.
Enustun E, Armbruster EG, Lee J, Zhang S, Yee BA, Malukhina K, Gu Y, Deep A, Naritomi JT, Liang Q, Aigner S, Adler BA, Cress BF, Doudna JA, Chaikeeratisak V, Cleveland DW, Ghassemian M, Bintu B, Yeo GW, Pogliano J, Corbett KD. Enustun E, et al. Among authors: adler ba. Nucleic Acids Res. 2024 Mar 30:gkae216. doi: 10.1093/nar/gkae216. Online ahead of print. Nucleic Acids Res. 2024. PMID: 38554115
Here, we identify a conserved phage nuclear shell-associated protein that we term Chimallin C (ChmC), which adopts a nucleic acid-binding fold, binds RNA with high affinity in vitro, and binds phage mRNAs in infected cells. ...
Here, we identify a conserved phage nuclear shell-associated protein that we term Chimallin C (ChmC), which adopts a nucleic acid-bin …
A phage nucleus-associated RNA-binding protein is required for jumbo phage infection.
Enustun E, Armbruster EG, Lee J, Zhang S, Yee BA, Gu Y, Deep A, Naritomi JT, Liang Q, Aigner S, Adler BA, Cress BF, Doudna JA, Chaikeeratisak V, Cleveland DW, Ghassemian M, Yeo GW, Pogliano J, Corbett KD. Enustun E, et al. Among authors: adler ba. bioRxiv [Preprint]. 2023 Sep 22:2023.09.22.559000. doi: 10.1101/2023.09.22.559000. bioRxiv. 2023. PMID: 37790334 Free PMC article. Updated. Preprint.
Here we identify a conserved phage nuclear shell-associated protein that we term Chimallin C (ChmC), which adopts a nucleic acid-binding fold, binds RNA with high affinity in vitro, and binds phage mRNAs in infected cells. ...
Here we identify a conserved phage nuclear shell-associated protein that we term Chimallin C (ChmC), which adopts a nucleic acid-bind …
Anti-MDA5-positive dermatomyositis and remission in a single referral centre population.
Tiniakou E, Mecoli CA, Kelly W, Albayda J, Paik JJ, Adler BL, Lin CT, Mammen AL, Danoff SK, Casciola-Rosen L, Christopher-Stine L. Tiniakou E, et al. Among authors: adler bl. Clin Exp Rheumatol. 2023 Mar;41(2):309-315. doi: 10.55563/clinexprheumatol/g4l70r. Epub 2023 Feb 15. Clin Exp Rheumatol. 2023. PMID: 36826791 Free PMC article.
OBJECTIVES: To describe a single-centre North American adult cohort of anti-MDA5-positive dermatomyositis patients, with emphasis on drug-free long-term remission. METHODS: We conducted an observational retrospective cohort study of anti-MDA5-positive DM patients. ...CONCL …
OBJECTIVES: To describe a single-centre North American adult cohort of anti-MDA5-positive dermatomyositis patients, with emphasis on drug-fr …
Anti-Leptospira immunoglobulin profiling in mice reveals strain specific IgG and persistent IgM responses associated with virulence and renal colonization.
Vernel-Pauillac F, Murray GL, Adler B, Boneca IG, Werts C. Vernel-Pauillac F, et al. Among authors: adler b. PLoS Negl Trop Dis. 2021 Mar 11;15(3):e0008970. doi: 10.1371/journal.pntd.0008970. eCollection 2021 Mar. PLoS Negl Trop Dis. 2021. PMID: 33705392 Free PMC article.
Similarly to whole inactivated bacteria used as human vaccines, this response is believed to confer only short-term, serogroup-specific protection. The immune response of hosts against leptospires has not been thoroughly studied, which complicates the testing of vaccine ca …
Similarly to whole inactivated bacteria used as human vaccines, this response is believed to confer only short-term, serogroup-specif …
Leptospiral LPS escapes mouse TLR4 internalization and TRIF‑associated antimicrobial responses through O antigen and associated lipoproteins.
Bonhomme D, Santecchia I, Vernel-Pauillac F, Caroff M, Germon P, Murray G, Adler B, Boneca IG, Werts C. Bonhomme D, et al. Among authors: adler b. PLoS Pathog. 2020 Aug 13;16(8):e1008639. doi: 10.1371/journal.ppat.1008639. eCollection 2020 Aug. PLoS Pathog. 2020. PMID: 32790743 Free PMC article.
All vertebrate species can be infected; humans are sensitive hosts whereas other species, such as rodents, may become long-term renal carrier reservoirs. Upon infection, innate immune responses are initiated by recognition of Microbial Associated Molecular Patterns (MAMPs) …
All vertebrate species can be infected; humans are sensitive hosts whereas other species, such as rodents, may become long-term renal …
Low-intensity vibration increases cartilage thickness in obese mice.
Pamon T, Bhandal V, Adler BJ, Ete Chan M, Rubin CT. Pamon T, et al. Among authors: adler bj. J Orthop Res. 2018 Feb;36(2):751-759. doi: 10.1002/jor.23795. Epub 2017 Dec 5. J Orthop Res. 2018. PMID: 29094382 Free PMC article.
RT-PCR analysis showed a reduction of aggrecan expression with high fat diet, while application of LIV reduced the expression of degradative MMP-13. Further, long-term HF diet resulted in subchondral bone thickening, compared to RD, providing early evidence of OA pathology …
RT-PCR analysis showed a reduction of aggrecan expression with high fat diet, while application of LIV reduced the expression of degradative …
Simplified Readability Metric Drives Improvement of Radiology Reports: an Experiment on Ultrasound Reports at a Pediatric Hospital.
Chen W, Durkin C, Huang Y, Adler B, Rust S, Lin S. Chen W, et al. Among authors: adler b. J Digit Imaging. 2017 Dec;30(6):710-717. doi: 10.1007/s10278-017-9972-7. J Digit Imaging. 2017. PMID: 28484918 Free PMC article.
To test it, a simplified "grade vs. length" readability metric is developed based on results from factor analysis of ten readability metrics applied to more than 500,000 radiology reports. To test the short-term effectiveness of a writing workshop, we measured the writing …
To test it, a simplified "grade vs. length" readability metric is developed based on results from factor analysis of ten readability metrics …
Obesity-driven disruption of haematopoiesis and the bone marrow niche.
Adler BJ, Kaushansky K, Rubin CT. Adler BJ, et al. Nat Rev Endocrinol. 2014 Dec;10(12):737-48. doi: 10.1038/nrendo.2014.169. Epub 2014 Oct 14. Nat Rev Endocrinol. 2014. PMID: 25311396 Review.
In addition to the increased adipose burden in visceral and subcutaneous compartments, obesity causes a marked increase in the size and number of adipocytes encroaching into the bone marrow space, almost certainly disturbing HSC interactions with neighbouring cells, which include …
In addition to the increased adipose burden in visceral and subcutaneous compartments, obesity causes a marked increase in the size and numb …
Bone structure and B-cell populations, crippled by obesity, are partially rescued by brief daily exposure to low-magnitude mechanical signals.
Chan ME, Adler BJ, Green DE, Rubin CT. Chan ME, et al. Among authors: adler bj. FASEB J. 2012 Dec;26(12):4855-63. doi: 10.1096/fj.12-209841. Epub 2012 Aug 16. FASEB J. 2012. PMID: 22898923 Free PMC article.
Using a murine model of diet-induced obesity, this study investigated the ability of mechanical signals to protect the skeletal-immune systems at the tissue, cellular, and molecular level. A long-term (7 mo) high-fat diet increased total adiposity (+62%), accelerated age-r …
Using a murine model of diet-induced obesity, this study investigated the ability of mechanical signals to protect the skeletal-immune syste …
Devastation of adult stem cell pools by irradiation precedes collapse of trabecular bone quality and quantity.
Green DE, Adler BJ, Chan ME, Rubin CT. Green DE, et al. Among authors: adler bj. J Bone Miner Res. 2012 Apr;27(4):749-59. doi: 10.1002/jbmr.1505. J Bone Miner Res. 2012. PMID: 22190044 Free article.
Stem cell depletion and compromised bone marrow resulting from radiation exposure fosters long-term deterioration of numerous physiologic systems, with the degradation of the skeletal system ultimately increasing the risk of fractures. ...
Stem cell depletion and compromised bone marrow resulting from radiation exposure fosters long-term deterioration of numerous physiol …
22 results