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Time required to initiate a clinical trial in Canada at the onset of the COVID-19 pandemic: an observational research-in-motion study.
Teo K, Fowler RA, Adhikari NKJ, Rishu A, Tsang JLY, Binnie A, Murthy S; Canadian Critical Care Trials Group. Teo K, et al. Among authors: adhikari nkj. CMAJ Open. 2023 Jul 4;11(4):E615-E620. doi: 10.9778/cmajo.20220129. Print 2023 Jul-Aug. CMAJ Open. 2023. PMID: 37402556 Free PMC article.
Adoption of template clinical trial agreements, greater harmonization or central coordination of ethics submissions, and long-term funding of platform trials that engage academic and community hospitals are potential solutions to improve trial start-up efficiency....
Adoption of template clinical trial agreements, greater harmonization or central coordination of ethics submissions, and long-term fu …
Effect of video camera monitoring feedback on hand hygiene compliance in neonatal intensive care unit, an interventional study.
Bilgin H, Sili U, Pazar N, Kucuker I, Kepenekli E, Yanar MA, Memisoglu A, Ozek E, Adhikari NK, Pinto R, Korten V. Bilgin H, et al. Among authors: adhikari nk. Am J Infect Control. 2023 Sep;51(9):1028-1033. doi: 10.1016/j.ajic.2022.12.011. Epub 2023 Jan 2. Am J Infect Control. 2023. PMID: 36603809 Clinical Trial.
CONCLUSION: In this study of HH monitoring using video-camera footage combined with an intervention including feedback and education, there were inconsistent improvements in HH compliance. However, these improvements were not sustained in the long term. Frequent feedback a …
CONCLUSION: In this study of HH monitoring using video-camera footage combined with an intervention including feedback and education, there …
Lower Versus Higher Exposure to Vasopressor Therapy in Vasodilatory Hypotension: A Systematic Review With Meta-Analysis.
Richards-Belle A, Hylands M, Muttalib F, Taran S, Rochwerg B, Day A, Mouncey PR, Radermacher P, Couban R, Asfar P, Adhikari NKJ, Lamontagne F. Richards-Belle A, et al. Among authors: adhikari nkj. Crit Care Med. 2023 Feb 1;51(2):254-266. doi: 10.1097/CCM.0000000000005736. Epub 2022 Nov 18. Crit Care Med. 2023. PMID: 36398968 Free PMC article.
DATA EXTRACTION: The primary outcome was 90-day all-cause mortality, with seven prespecified subgroups. Secondary outcomes included shorter- and longer-term mortality, use of life-sustaining therapies, vasopressor-related complications, neurologic outcome, and quality of l …
DATA EXTRACTION: The primary outcome was 90-day all-cause mortality, with seven prespecified subgroups. Secondary outcomes included shorter- …
White Paper on Early Critical Care Services in Low Resource Settings.
Losonczy LI, Papali A, Kivlehan S, Calvello Hynes EJ, Calderon G, Laytin A, Moll V, Al Hazmi A, Alsabri M, Aryal D, Atua V, Becker T, Benzoni N, Dippenaar E, Duneant E, Girma B, George N, Gupta P, Jaung M, Hollong B, Kabongo D, Kruisselbrink RJ, Lee D, Maldonado A, May J, Osei-Ampofo M, Osman YO, Owoo C, Rouhani SA, Sawe H, Schnorr D, Shrestha GS, Sohoni A, Sultan M, Tenner AG, Yusuf H, Adhikari NK, Murthy S, Kissoon N, Marshall J, Khoury A, Bellou A, Wallis L, Reynolds T. Losonczy LI, et al. Among authors: adhikari nk. Ann Glob Health. 2021 Nov 3;87(1):105. doi: 10.5334/aogh.3377. eCollection 2021. Ann Glob Health. 2021. PMID: 34786353 Free PMC article.
Education initiatives for physicians, nurses, and allied health staff that focus on protocolized emergency response training can bridge the workforce gap in the short-term; however, each country's current human resources must be evaluated to decide on the duration of train …
Education initiatives for physicians, nurses, and allied health staff that focus on protocolized emergency response training can bridge the …
Association between sepsis survivorship and long-term cardiovascular outcomes in adults: a systematic review and meta-analysis.
Kosyakovsky LB, Angriman F, Katz E, Adhikari NK, Godoy LC, Marshall JC, Ferreyro BL, Lee DS, Rosenson RS, Sattar N, Verma S, Toma A, Englesakis M, Burstein B, Farkouh ME, Herridge M, Ko DT, Scales DC, Detsky ME, Bibas L, Lawler PR. Kosyakovsky LB, et al. Among authors: adhikari nk. Intensive Care Med. 2021 Sep;47(9):931-942. doi: 10.1007/s00134-021-06479-y. Epub 2021 Aug 9. Intensive Care Med. 2021. PMID: 34373953
PURPOSE: We aimed to determine the association between sepsis and long-term cardiovascular events. METHODS: We conducted a systematic review of observational studies evaluating post-sepsis cardiovascular outcomes in adult sepsis survivors. ...CONCLUSIONS: Surviving sepsis …
PURPOSE: We aimed to determine the association between sepsis and long-term cardiovascular events. METHODS: We conducted a systematic …
Short-and long-term outcomes of sustained low efficiency dialysis vs continuous renal replacement therapy in critically ill patients with acute kidney injury.
Harvey AK, Burns KEA, McArthur E, Adhikari NKJ, Li D, Kitchlu A, Meraz-Munõz A, Garg AX, Nash DM, Perez-Sanchez A, Beaubien-Souligny W, Bagshaw SM, Friedrich JO, Silver SA, Wald R. Harvey AK, et al. Among authors: adhikari nkj. J Crit Care. 2021 Apr;62:76-81. doi: 10.1016/j.jcrc.2020.11.003. Epub 2020 Nov 22. J Crit Care. 2021. PMID: 33290929
However, there is limited information on the short- and long-term outcomes of SLED compared to CRRT. METHODS: We conducted a retrospective cohort study of patients with AKI who commenced either SLED or CRRT in ICUs at a tertiary care hospital in Toronto, Canada. ...
However, there is limited information on the short- and long-term outcomes of SLED compared to CRRT. METHODS: We conducted a retrospe …
Rate and risk factors for rehospitalisation in sepsis survivors: systematic review and meta-analysis.
Shankar-Hari M, Saha R, Wilson J, Prescott HC, Harrison D, Rowan K, Rubenfeld GD, Adhikari NKJ. Shankar-Hari M, et al. Among authors: adhikari nkj. Intensive Care Med. 2020 Apr;46(4):619-636. doi: 10.1007/s00134-019-05908-3. Epub 2020 Jan 23. Intensive Care Med. 2020. PMID: 31974919 Free PMC article. Review.
PURPOSE: Sepsis survivors have a higher risk of rehospitalisation and of long-term mortality. We assessed the rate, diagnosis, and independent predictors for rehospitalisation in adult sepsis survivors. ...
PURPOSE: Sepsis survivors have a higher risk of rehospitalisation and of long-term mortality. We assessed the rate, diagnosis, and in …
The harm of high-frequency oscillatory ventilation (HFOV) in ARDS is not related to a high baseline risk of acute cor pulmonale or short-term changes in hemodynamics.
Angriman F, Ferreyro BL, Donaldson L, Cuthbertson BH, Ferguson ND, Bollen CW, Bachman TE, Lamontagne F, Adhikari NKJ. Angriman F, et al. Among authors: adhikari nkj. Intensive Care Med. 2020 Jan;46(1):132-134. doi: 10.1007/s00134-019-05806-8. Epub 2019 Oct 29. Intensive Care Med. 2020. PMID: 31664500 Free PMC article. No abstract available.
Pharmacological interventions for the treatment of delirium in critically ill adults.
Burry L, Hutton B, Williamson DR, Mehta S, Adhikari NK, Cheng W, Ely EW, Egerod I, Fergusson DA, Rose L. Burry L, et al. Among authors: adhikari nk. Cochrane Database Syst Rev. 2019 Sep 3;9(9):CD011749. doi: 10.1002/14651858.CD011749.pub2. Cochrane Database Syst Rev. 2019. PMID: 31479532 Free PMC article.
BACKGROUND: Although delirium is typically an acute reversible cognitive impairment, its presence is associated with devastating impact on both short-term and long-term outcomes for critically ill patients. Advances in our understanding of the negative impact of del …
BACKGROUND: Although delirium is typically an acute reversible cognitive impairment, its presence is associated with devastating impact on b …
Barriers to supportive care during the Ebola virus disease outbreak in West Africa: Results of a qualitative study.
Loignon C, Nouvet E, Couturier F, Benhadj L, Adhikari NKJ, Murthy S, Fowler RA, Lamontagne F. Loignon C, et al. Among authors: adhikari nkj. PLoS One. 2018 Sep 5;13(9):e0201091. doi: 10.1371/journal.pone.0201091. eCollection 2018. PLoS One. 2018. PMID: 30183718 Free PMC article. Clinical Trial.
Addressing these in the inter-outbreak period will be useful to improve patient care and outcomes during inevitable future outbreaks. Promoting community trust and engagement through long-term capacity building of the healthcare workforce and infrastructure would increase …
Addressing these in the inter-outbreak period will be useful to improve patient care and outcomes during inevitable future outbreaks. Promot …
18 results