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Vascular permeability modulation at the cell, microvessel, or whole organ level: towards closing gaps in our knowledge.
Curry FR, Adamson RH. Curry FR, et al. Among authors: adamson rh. Cardiovasc Res. 2010 Jul 15;87(2):218-29. doi: 10.1093/cvr/cvq115. Epub 2010 Apr 23. Cardiovasc Res. 2010. PMID: 20418473 Free PMC article. Review.
Here we focus on current problems that limit the integration of our knowledge of mechanisms investigated in detail at the cellular level into a more complete understanding of modulation of blood-to-tissue exchange in whole organs when the endothelial barrier is exposed to acute a …
Here we focus on current problems that limit the integration of our knowledge of mechanisms investigated in detail at the cellular level int …
Effects of long-term oral administration of DDT on nonhuman primates.
Takayama S, Sieber SM, Dalgard DW, Thorgeirsson UP, Adamson RH. Takayama S, et al. Among authors: adamson rh. J Cancer Res Clin Oncol. 1999;125(3-4):219-25. doi: 10.1007/s004320050266. J Cancer Res Clin Oncol. 1999. PMID: 10235477
Because of reports on tumorigenic activity in different animal species exposed to DDT a decision was made in 1969 to evaluate the long-term effects of DDT on 24 cynomolgus and rhesus monkeys. DDT (20 mg/kg) was given in the diet for 130 months, followed by an observation p …
Because of reports on tumorigenic activity in different animal species exposed to DDT a decision was made in 1969 to evaluate the long-te …
Long-term feeding of sodium saccharin to nonhuman primates: implications for urinary tract cancer.
Takayama S, Sieber SM, Adamson RH, Thorgeirsson UP, Dalgard DW, Arnold LL, Cano M, Eklund S, Cohen SM. Takayama S, et al. Among authors: adamson rh. J Natl Cancer Inst. 1998 Jan 7;90(1):19-25. doi: 10.1093/jnci/90.1.19. J Natl Cancer Inst. 1998. PMID: 9428778
Numerous epidemiologic studies have not shown any evidence of increased urothelial proliferation associated with ingestion of sodium saccharin. PURPOSE: Our purpose was to determine the effects of long-term feeding of sodium saccharin to three species of nonhuman primates. …
Numerous epidemiologic studies have not shown any evidence of increased urothelial proliferation associated with ingestion of sodium sacchar …
Lymphoma induction by heterocyclic amines in E mu-pim-1 transgenic mice.
Sørensen IK, Kristiansen E, Mortensen A, van Kreijl C, Adamson RH, Thorgeirsson SS. Sørensen IK, et al. Among authors: adamson rh. Arch Toxicol Suppl. 1997;19:377-86. doi: 10.1007/978-3-642-60682-3_36. Arch Toxicol Suppl. 1997. PMID: 9079225
The usefulness of transgenic E mu-pim-1 mice bearing in their genome the pim-1 oncogene supplemented with an upstream immunoglobulin enhancer and a downstream murine leukaemia virus long terminal repeat, as sensitive test organisms was studied in two short-term carcinogeni …
The usefulness of transgenic E mu-pim-1 mice bearing in their genome the pim-1 oncogene supplemented with an upstream immunoglobulin enhance …
Short-term carcinogenicity testing of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in E(mu)-pim-1 transgenic mice.
Sørensen IK, Mortensen A, Kristiansen E, van Kreijl C, Adamson RH, Thorgeirsson SS. Sørensen IK, et al. Among authors: adamson rh. Carcinogenesis. 1996 Oct;17(10):2221-7. doi: 10.1093/carcin/17.10.2221. Carcinogenesis. 1996. PMID: 8895492
The usefulness of transgenic E(mu)-pim-1 mice over-expressing the pim-1 oncogene in lymphoid tissues, as sensitive test organisms was studied in a short-term carcinogenicity study. The mice were fed standard diet Altromin 1314 supplemented either with 0.03% 2-amino-1-methy …
The usefulness of transgenic E(mu)-pim-1 mice over-expressing the pim-1 oncogene in lymphoid tissues, as sensitive test organisms was studie …
Tumor incidence in a chemical carcinogenesis study of nonhuman primates.
Thorgeirsson UP, Dalgard DW, Reeves J, Adamson RH. Thorgeirsson UP, et al. Among authors: adamson rh. Regul Toxicol Pharmacol. 1994 Apr;19(2):130-51. doi: 10.1006/rtph.1994.1013. Regul Toxicol Pharmacol. 1994. PMID: 8041912
A large number of substances including a variety of food additives, food components, environmental contaminants, N-nitroso compounds, "classical" rodent carcinogens, antineoplastic agents, and immunosuppressive agents have been evaluated for long-term carcinogenic activity …
A large number of substances including a variety of food additives, food components, environmental contaminants, N-nitroso compounds, "class …
Carcinogenicity and hepatotoxicity of cycasin and its aglycone methylazoxymethanol acetate in nonhuman primates.
Sieber SM, Correa P, Dalgard DW, McIntire KR, Adamson RH. Sieber SM, et al. Among authors: adamson rh. J Natl Cancer Inst. 1980 Jul;65(1):177-89. J Natl Cancer Inst. 1980. PMID: 6248673
Four of the monkeys developed hepatocellular carcinomas, and 2 had multiple primary tumors including hepatocellular carcinomas, renal carcinomas, squamous cell carcinomas of the esophagus, and adenocarcinomas of the small intestine. Our results showed that long-term admini …
Four of the monkeys developed hepatocellular carcinomas, and 2 had multiple primary tumors including hepatocellular carcinomas, renal carcin …
In vitro alpha-fetoprotein synthesis by monkey hepatocellular carcinoma.
Princler GL, McIntire KR, Adamson RH. Princler GL, et al. Among authors: adamson rh. J Natl Cancer Inst. 1978 Mar;60(3):643-8. doi: 10.1093/jnci/60.3.643. J Natl Cancer Inst. 1978. PMID: 75269
Five monkeys were treated ip with N-nitrosodiethylamine (DENA), and one was treated with 1-nitrosopiperidine (PIP), starting within 2 months of birth, until hepatocellular carcinoma (HCC) developed. All animals except the PIP-treated monkey had much elevated serum alpha-fe …
Five monkeys were treated ip with N-nitrosodiethylamine (DENA), and one was treated with 1-nitrosopiperidine (PIP), starting within 2 months …