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Antenatal Endotoxin Induces Dysanapsis in Experimental Bronchopulmonary Dysplasia.
McGinn EA, Bye E, Gonzalez T, Sosa A, Bilodeaux J, Seedorf G, Smith BJ, Abman SH, Mandell EW. McGinn EA, et al. Among authors: abman sh. Am J Respir Cell Mol Biol. 2024 Apr;70(4):283-294. doi: 10.1165/rcmb.2023-0157OC. Am J Respir Cell Mol Biol. 2024. PMID: 38207120
Fetal rats were exposed to intraamniotic ETX (10 mug) or saline solution (control) 2 days before term. We performed extensive structural and functional evaluation of the proximal airways and distal lung in 2-week-old rats. ...
Fetal rats were exposed to intraamniotic ETX (10 mug) or saline solution (control) 2 days before term. We performed extensive structu …
Pulmonary Vascular Phenotypes of Prematurity: The Path to Precision Medicine.
Mirza H, Mandell EW, Kinsella JP, McNamara PJ, Abman SH. Mirza H, et al. Among authors: abman sh. J Pediatr. 2023 Aug;259:113444. doi: 10.1016/j.jpeds.2023.113444. Epub 2023 Apr 25. J Pediatr. 2023. PMID: 37105409
As with term newborns, severe hypoxemia with acute respiratory failure (HRF) in preterm infants can be due to marked elevation of pulmonary artery pressure with extrapulmonary shunt, traditionally referred to as persistent pulmonary hypertension of the newborn (PPHN). Tran …
As with term newborns, severe hypoxemia with acute respiratory failure (HRF) in preterm infants can be due to marked elevation of pul …
Novel use of riociguat in infants with severe pulmonary arterial hypertension unable to wean from inhaled nitric oxide.
Domingo LT, Ivy DD, Abman SH, Grenolds AM, MacLean JT, Breaux JA, Minford KJ, Frank BS. Domingo LT, et al. Among authors: abman sh. Front Pediatr. 2022 Dec 1;10:1014922. doi: 10.3389/fped.2022.1014922. eCollection 2022. Front Pediatr. 2022. PMID: 36533232 Free PMC article.
CASE PRESENTATION: We report the case of two infants with severe suprasystemic pulmonary hypertension who were successfully treated with riociguat after failure to wean off inhaled nitric oxide (iNO) despite combination PAH therapy. Case 1 is a 6-month-old term male with T …
CASE PRESENTATION: We report the case of two infants with severe suprasystemic pulmonary hypertension who were successfully treated with rio …
Association of Racial Disparities With In-Hospital Outcomes in Severe Bronchopulmonary Dysplasia.
Lewis TR, Kielt MJ, Walker VP, Levin JC, Guaman MC, Panitch HB, Nelin LD, Abman SH; Bronchopulmonary Dysplasia Collaborative. Lewis TR, et al. Among authors: abman sh. JAMA Pediatr. 2022 Sep 1;176(9):852-859. doi: 10.1001/jamapediatrics.2022.2663. JAMA Pediatr. 2022. PMID: 35913704 Free PMC article.
IMPORTANCE: Bronchopulmonary dysplasia (BPD) is the most common serious morbidity of preterm birth. Short-term respiratory outcomes for infants with the most severe forms of BPD are highly variable. ...
IMPORTANCE: Bronchopulmonary dysplasia (BPD) is the most common serious morbidity of preterm birth. Short-term respiratory out …
Pulmonary vasodilator strategies in neonates with acute hypoxemic respiratory failure and pulmonary hypertension.
Cookson MW, Abman SH, Kinsella JP, Mandell EW. Cookson MW, et al. Among authors: abman sh. Semin Fetal Neonatal Med. 2022 Aug;27(4):101367. doi: 10.1016/j.siny.2022.101367. Epub 2022 Jun 3. Semin Fetal Neonatal Med. 2022. PMID: 35688685 Free PMC article. Review.
This article reviews the pathophysiology and management of PPHN in term newborns with AHRF while highlighting both animal and human data to inform a physiologic approach to the use of PH-targeted therapies....
This article reviews the pathophysiology and management of PPHN in term newborns with AHRF while highlighting both animal and human d …
Physiological aspects of cardiopulmonary dysanapsis on exercise in adults born preterm.
Duke JW, Lewandowski AJ, Abman SH, Lovering AT. Duke JW, et al. Among authors: abman sh. J Physiol. 2022 Feb;600(3):463-482. doi: 10.1113/JP281848. Epub 2022 Jan 12. J Physiol. 2022. PMID: 34961925 Free PMC article. Review.
However, the incidence of bronchopulmonary dysplasia, the chronic lung disease after preterm birth, has not changed. Studies of the long-term follow-up of adults born preterm have shown persistent abnormalities of respiratory, cardiovascular and cardiopulmonary func …
However, the incidence of bronchopulmonary dysplasia, the chronic lung disease after preterm birth, has not changed. Studies of the l …
Invasive mechanical ventilation at 36 weeks post-menstrual age, adverse outcomes with a comparison of recent definitions of bronchopulmonary dysplasia.
Guaman MC, Pishevar N, Abman SH, Keszler M, Truog WE, Panitch H, Nelin LD. Guaman MC, et al. Among authors: abman sh. J Perinatol. 2021 Aug;41(8):1936-1942. doi: 10.1038/s41372-021-01102-w. Epub 2021 May 25. J Perinatol. 2021. PMID: 34035454 Free PMC article.
The use of type 2 sBPD or Grade 3 BPD would enhance the ability to target future studies to those infants with sBPD at the highest risk of adverse long-term outcomes....
The use of type 2 sBPD or Grade 3 BPD would enhance the ability to target future studies to those infants with sBPD at the highest risk of a …
Established severe BPD: is there a way out? Change of ventilatory paradigms.
Sindelar R, Shepherd EG, Ågren J, Panitch HB, Abman SH, Nelin LD; Bronchopulmonary Dysplasia Collaborative. Sindelar R, et al. Among authors: abman sh. Pediatr Res. 2021 Dec;90(6):1139-1146. doi: 10.1038/s41390-021-01558-8. Epub 2021 May 19. Pediatr Res. 2021. PMID: 34012026 Review.
Despite efforts to prevent BPD, many of these infants still develop severe BPD (sBPD) and require long-term invasive mechanical ventilation. The focus of research and clinical management has been on the prevention of BPD, which has had only modest success. ...Patients with …
Despite efforts to prevent BPD, many of these infants still develop severe BPD (sBPD) and require long-term invasive mechanical venti …
Pulmonary Hypertension: The Hidden Danger for Newborns.
Abman SH. Abman SH. Neonatology. 2021;118(2):211-217. doi: 10.1159/000516107. Epub 2021 May 5. Neonatology. 2021. PMID: 33951650 Free PMC article. Review.
A major gap for improving outcomes of preterm infants with PH has been the limited characterization of the distinct settings of PH and related disease-specific mechanisms in preterm infants that represent diverse pulmonary vascular phenotypes of prematurity. In comparison with …
A major gap for improving outcomes of preterm infants with PH has been the limited characterization of the distinct settings of PH and relat …
85 results